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  4. TNKS 22

TNKS 22 (compound 22) is an orally active and selective tankyrase inhibitor. TNKS 22 inhibits TNKS1 and TNKS2 with IC50s of 0.1 and 4.1 nM, respectively.

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TNKS 22

TNKS 22 화학구조

CAS No. : 1507362-00-6

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TNKS 22 Related Antibodies

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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제품 설명

TNKS 22 (compound 22) is an orally active and selective tankyrase inhibitor. TNKS 22 inhibits TNKS1 and TNKS2 with IC50s of 0.1 and 4.1 nM, respectively[1].

Cellular Effect
Cell Line Type Value Description References
DLD-1 IC50
0.6 nM
Compound: 22
Inhibition of TNKS in human DLD1 cells expressing APC mutant assessed as inhibition of super-Topflash reporter gene transcription after 40 to 48 hrs by dual-glo luciferase reporter gene assay
Inhibition of TNKS in human DLD1 cells expressing APC mutant assessed as inhibition of super-Topflash reporter gene transcription after 40 to 48 hrs by dual-glo luciferase reporter gene assay
[PMID: 24294969]
SW480 EC50
3.9 nM
Compound: 22
Inhibition of TNKS in human SW480 cells assessed as accumulation of axin-2 into cytoplasmic foci after 24 hrs by Hoechst dye-based assay
Inhibition of TNKS in human SW480 cells assessed as accumulation of axin-2 into cytoplasmic foci after 24 hrs by Hoechst dye-based assay
[PMID: 24294969]
SW480 IC50
0.004 μM
Compound: 22
Inhibition of TNKS in human SW480 cells assessed as degradation of total pool of beta-catenin after 40 to 48 hrs
Inhibition of TNKS in human SW480 cells assessed as degradation of total pool of beta-catenin after 40 to 48 hrs
[PMID: 24294969]
분자량

475.56

화학식

C25H25N5O3S
CAS No.
SMILES

O=C1C2=CC=CC=C2NC(SCCC(N[C@@H]3CC[C@@H](C4=NN=C(C5=CC=CC=C5)O4)CC3)=O)=N1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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TNKS 22 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNKS 221507362-00-6TNKS-IN-22TNKS22TNKS-22PARPpoly ADP ribose polymerasetankyraseTNKS1TNKS2Inhibitorinhibitorinhibit

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상품명:
TNKS 22
Cat. No.:
HY-12601
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