Xanthosine dihydrate

Cat. No.: HY-W013803: Data Sheet Handling Instructions
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Xanthosine dihydrate is a nucleoside derived from xanthine and ribose. Xanthosine dihydrate activates the AMPK/FoxO1/AKT/GSK3β signaling cascade. Xanthosine dihydrate promotes cell proliferation and regulates blood glucose metabolism. Xanthosine dihydrate increases milk production in cows and goats. Xanthosine dihydrate is used in mammary stem cell and type 2 diabetes research.

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Xanthosine dihydrate 화학구조

CAS No. : 5968-90-1

사이즈		재고
MOQ		Minimum order quantity
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100 mg		견적 받기
250 mg		견적 받기
Other size		견적 받기

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Other In-stock Forms of Xanthosine dihydrate:

Xanthosine

Other Forms of Xanthosine dihydrate:

Xanthosine In-stock

3 Publications Citing Use of MCE Xanthosine dihydrate

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Human Endogenous Metabolite Microbial Metabolite

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Akt Akt1 Akt2 Akt3

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

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FOXO1 FOXO3

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

Human Endogenous Metabolite

Microbial Metabolite

In Vitro

Xanthosine (200 μM) dihydrate increases the population of bovine mammary epithelial cells (MEC) during the exponential phase of cell growth, reduces the doubling time, promotes symmetric cell division^[1].
Xanthosine (1.75-17.6 μM; 2 h) dihydrate enhances glucose uptake, decreases glucose production, increases glycogen content, and activates AKT phosphorylation in FFA-induced CC1 hepatocytes^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[3]

Cell Line:	CC1 hepatocytes treated with FFA
Concentration:	1.75 μM, 3.52 μM, 7.04 μM, 10.56 μM, 14.07 μM, 17.6 μM
Incubation Time:	2 h
Result:	Upregulated AMPK phosphorylation and downregulated PEPCK and G6Pase protein expression. Dose-dependently upregulated FoxO1 phosphorylation at Ser256. Increased AKT phosphorylation, GSK-3β phosphorylation at Ser9, and GS phosphorylation.

In Vivo

Xanthosine (9.6 mg in 300 μL PBS; i.p.; 14 consecutive days) dihydrate has a latent negative effect on bovine mammary cell proliferation in immunodeficient mice with bovine mammary implants^[2].
Xanthosine (up to 5 mg/kg) dihydrate has no effect on the cat blood pressure^[4].
Xanthosine (1.5-2 mL; 10 mM; intraductal infusion and parenchymal injection; 5 consecutive days) dihydrate significantly increases the number of label-retaining epithelial cells (LREC) and telomerase activity in the mammary glands of female Holstein calves, indicating an expansion of the mammary stem cell population^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NOD-SCID mice (female, 3-week-old) with bovine mammary implants^[2]
Dosage:	9.6 mg in 300 µL PBS
Administration:	i.p., 14 consecutive days
Result:	Did not affect the relative number of label-retaining epithelial cells (LRECs) in bovine mammary implants. Showed no significant long-term or latent effect on the relative proportion of different cell populations in the bovine mammary implants, including stem cells. Reduced the levels of PCNA-positive and BrdU-positive cells by 60% and 30%, respectively, after 11 weeks.

분자량

320.26

화학식

C₁₀H₁₆N₄O₈

CAS No.

5968-90-1

SMILES

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(NC3=O)=O)=C3N=C2)O1.[2H2O]

Structure Classification

Others

Initial Source

Endogenous metabolite

선적

Room temperature in continental US; may vary elsewhere.

보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Choudhary RK, et al. In vitro expansion of the mammary stem/progenitor cell population by xanthosine treatment. BMC Cell Biol. 2012 Jun 14;13:14. [Content Brief]

[2]. Rauner G, et al. Xanthosine administration does not affect the proportion of epithelial stem cells in bovine mammary tissue, but has a latent negative effect on cell proliferation. Exp Cell Res. 2014 Oct 15;328(1):186-196. [Content Brief]

[3]. Ahmed SA, et al. Xanthosine, a purine glycoside mediates hepatic glucose homeostasis through inhibition of gluconeogenesis and activation of glycogenesis via regulating the AMPK/ FoxO1/AKT/GSK3β signaling cascade. Chem Biol Interact. 2023 Feb 1;371:110347. [Content Brief]

[4]. MOULTON, et al. Histamine release and pain production by xanthosine and related compounds. Br J Pharmacol Chemother. 1957 Sep;12(3):365-70. [Content Brief]

[5]. Capuco AV, et al. In vivo expansion of the mammary stem/ progenitor cell population by xanthosine infusion. Exp Biol Med (Maywood). 2009 Apr;234(4):475-82. [Content Brief]

[6]. Choudhary S, et, al. Examination of the xanthosine response on gene expression of mammary epithelial cells using RNA-seq technology. J Anim Sci Technol. 2018 Jul 13;60:18. [Content Brief]