5968-90-1
5968-90-1
Chemical Structure
Xanthosine dihydrate
- CAS. Nr.: 5968-90-1
- Formula:C10H16N4O8
- Molecular Weight:320.26
SMILES: OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(NC3=O)=O)=C3N=C2)O1.[2H2O]
Biological Activity: Xanthosine dihydrate is a nucleoside derived from xanthine and ribose. Xanthosine dihydrate activates the AMPK/FoxO1/AKT/GSK3β signaling cascade. Xanthosine dihydrate promotes cell proliferation and regulates blood glucose metabolism. Xanthosine dihydrate increases milk production in cows and goats. Xanthosine dihydrate is used in mammary stem cell and type 2 diabetes research[1][2][3][4][5][6].
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Xanthosine dihydrate | Xanthosine dihydrate is a nucleoside derived from xanthine and ribose. Xanthosine dihydrate activates the AMPK/FoxO1/AKT/GSK3β signaling cascade. Xanthosine dihydrate promotes cell proliferation and regulates blood glucose metabolism. Xanthosine dihydrate increases milk production in cows and goats. Xanthosine dihydrate is used in mammary stem cell and type 2 diabetes research. | |||||||||||||||||||||
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References
- [1]. Choudhary RK, et al. In vitro expansion of the mammary stem/progenitor cell population by xanthosine treatment. BMC Cell Biol. 2012 Jun 14;13:14. [Content Brief]
- [2]. Rauner G, et al. Xanthosine administration does not affect the proportion of epithelial stem cells in bovine mammary tissue, but has a latent negative effect on cell proliferation. Exp Cell Res. 2014 Oct 15;328(1):186-196. [Content Brief]
- [3]. Ahmed SA, et al. Xanthosine, a purine glycoside mediates hepatic glucose homeostasis through inhibition of gluconeogenesis and activation of glycogenesis via regulating the AMPK/ FoxO1/AKT/GSK3β signaling cascade. Chem Biol Interact. 2023 Feb 1;371:110347. [Content Brief]
- [4]. MOULTON, et al. Histamine release and pain production by xanthosine and related compounds. Br J Pharmacol Chemother. 1957 Sep;12(3):365-70. [Content Brief]
- [5]. Capuco AV, et al. In vivo expansion of the mammary stem/ progenitor cell population by xanthosine infusion. Exp Biol Med (Maywood). 2009 Apr;234(4):475-82. [Content Brief]
- [6]. Choudhary S, et, al. Examination of the xanthosine response on gene expression of mammary epithelial cells using RNA-seq technology. J Anim Sci Technol. 2018 Jul 13;60:18. [Content Brief]
Keywords
