2. Anti-infection
  3. Bacterial Antibiotic
  4. Delamanid

デラマニド  (Synonyms: Delamanid; OPC-67683)

製品番号: HY-10846 純度: 99.95%
COA 取扱説明書 Technical Support

Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids.

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CAS 番号 : 681492-22-8

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 59 在庫あり
Solution
10 mM * 1 mL in DMSO USD 59 在庫あり
Solid
2 mg $30 在庫あり
5 mg $50 在庫あり
10 mg $80 在庫あり
25 mg $180 在庫あり
50 mg $312 在庫あり
100 mg $460 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 8 publication(s) in Google Scholar

Other Forms of Delamanid:

デラマニド 関連抗体

Top Publications Citing Use of Products

    Delamanid purchased from MedChemExpress. Usage Cited in: Drug Dev Ind Pharm. 2025 Jul 24:1-16.  [Abstract]

    Effect of pure Delamanid (0-10μg/mL) and selected delamanid-loaded microemulsion formulation on cell viability of a549 (a),ncI-h358 (B) cell line using mtt assay treated with various concentrations after 24 h.

    Delamanid purchased from MedChemExpress. Usage Cited in: Drug Dev Ind Pharm. 2025 Jul 24:1-16.  [Abstract]

    Delamanid (0.125, 0.25, 0.5, 1, 2 μg/mL;24 h) showed no effect in levels of inflammatory cytokines;Il-1β (a), Il-6 (B) produced after expo-sure to nr8383 cells.

    Delamanid purchased from MedChemExpress. Usage Cited in: Drug Dev Ind Pharm. 2025 Jul 24:1-16.  [Abstract]

    Delamanid (0.125, 0.25, 0.5, 1, 2 μg/mL;24 h) showed no effect in lnitric oxide (NO) concentration to nr8383 cells.

    Delamanid purchased from MedChemExpress. Usage Cited in: Drug Dev Ind Pharm. 2025 Jul 24:1-16.  [Abstract]

    The viability was compared among M. bovis samples treated with Delamanid (0.156, 0.313, 0.625, 1.25, 2.5, 5 μg/mL) at varying concentrations.

    Delamanid purchased from MedChemExpress. Usage Cited in: Dis Model Mech. 2021 Dec 1;14(12):dmm049145.  [Abstract]

    Delamanid (10 μM) resulted in a significant reduction of the bacterial signal in M. marinum-tdTomato yolk-infected zebrafish embryos.

    Antibiotic アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids[1].

    Cellular Effect
    Cell Line Type Value Description References
    HepG2 CC50
    107.5 μg/mL
    Compound: Delamanid
    Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
    		[PMID: 26487912]
    MRC5 IC50
    0.43 μM
    Compound: 5; OPC-67683
    Antitrypanosomal activity against Trypanosoma cruzi infected in human MRC5 cells assessed as parasite growth inhibition incubated for 7 days by chlorophenol red alpha-D-galactopyranoside-based assay
    Antitrypanosomal activity against Trypanosoma cruzi infected in human MRC5 cells assessed as parasite growth inhibition incubated for 7 days by chlorophenol red alpha-D-galactopyranoside-based assay
    		[PMID: 26901446]
    MRC5 IC50
    > 64 μM
    Compound: 5; OPC-67683
    Cytotoxicity against human MRC5 cells assessed as cell viability incubated for 72 hrs by fluorimetric assay
    Cytotoxicity against human MRC5 cells assessed as cell viability incubated for 72 hrs by fluorimetric assay
    		[PMID: 26901446]
    Vero CC50
    > 32 μg/mL
    Compound: Delamanid
    Cytotoxicity against African green monkey vero cells assessed as reduction in cell viability
    Cytotoxicity against African green monkey vero cells assessed as reduction in cell viability
    		[PMID: 35777718]
    体外実験

    Delamanid inhibits the synthesisi of mucolic acids, cruciala component of the cell wall of the Mycobacterium tuberculosis complex[1].
    Delamanid shows more potent antibacterial activity against drug-susceptible and drug-resistant strains of M. tuberculosis[2].
    Delamanid do not affect rifampin, pyrazinamide, and isoniazid exposure; the ethambutol AUCτ and Cmax values are about 25% higher with delamanid coadministration[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    デラマニド 関連抗体
    体内実験

    Delamanid (orally administration; 30 mg/kg; 5 days) results in sterile cures in a mouse model of VL[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    臨床実験
    分子量

    534.48

    分子式

    C25H25F3N4O6
    CAS 番号
    Appearance

    Solid

    Color

    Off-white to yellow

    SMILES

    FC(F)(F)OC1=CC=C(OC2CCN(C3=CC=C(OC[C@@]4(C)CN5C(O4)=NC([N+]([O-])=O)=C5)C=C3)CC2)C=C1
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 20 mg/mL (37.42 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Ethanol : 2 mg/mL (3.74 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.8710 mL 9.3549 mL 18.7098 mL
    5 mM 0.3742 mL 1.8710 mL 3.7420 mL
    10 mM 0.1871 mL 0.9355 mL 1.8710 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

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    濃度 （終了）

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    体積 （終了）

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

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    Dosing volume
    (per animal)

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    純度とドキュメンテーション

    純度: 99.95%

    COA (245 KB) HNMR (292 KB) RP-HPLC (243 KB) LCMS (94 KB) OR (250 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    Ethanol / DMSO 1 mM 1.8710 mL 9.3549 mL 18.7098 mL 46.7744 mL
    DMSO 5 mM 0.3742 mL 1.8710 mL 3.7420 mL 9.3549 mL
    10 mM 0.1871 mL 0.9355 mL 1.8710 mL 4.6774 mL
    15 mM 0.1247 mL 0.6237 mL 1.2473 mL 3.1183 mL
    20 mM 0.0935 mL 0.4677 mL 0.9355 mL 2.3387 mL
    25 mM 0.0748 mL 0.3742 mL 0.7484 mL 1.8710 mL
    30 mM 0.0624 mL 0.3118 mL 0.6237 mL 1.5591 mL
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    Delamanid Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Delamanid681492-22-8OPC-67683OPC67683OPC 67683BacterialAntibioticInhibitorinhibitorinhibit

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    製品名:
    Delamanid
    製品番号:
    HY-10846
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