2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Ibudilast

Ibudilast  (Synonyms: イブジラスト; KC-404; AV-411; MN-166)

製品番号: HY-B0763 純度: 99.87%
COA 取扱説明書 Technical Support

Ibudilast (KC-404; AV-411; MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 50847-11-5

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 35 在庫あり
Solution
10 mM * 1 mL in DMSO USD 35 在庫あり
Solid
5 mg $32 在庫あり
10 mg $46 在庫あり
50 mg $65 在庫あり
100 mg $101 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 10 publication(s) in Google Scholar

Other Forms of Ibudilast:

Ibudilast 関連抗体

Top Publications Citing Use of Products

    Ibudilast purchased from MedChemExpress. Usage Cited in: Addict Biol. 2025 Apr;30(4):e70033.  [Abstract]

    Expression levels of TLR4, p‐NF‐κB and IL‐6 in the prefrontal cortex following treatment with 3 mg/kg and 10 mg/kg Ibudilast.

    Ibudilast purchased from MedChemExpress. Usage Cited in: Addict Biol. 2025 Apr;30(4):e70033.  [Abstract]

    Expression of TLR4 in neurons, microglia and astrocytes following treatment with 3 and 10 mg/kg Ibudilast.

    Phosphodiesterase (PDE) アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Ibudilast (KC-404; AV-411; MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia[1].

    IC50 & Target

    phosphodiesterase[1]
    体外実験

    Ibudilast (1~100 μM; 24 hours; microglia) suppresses both IL-1β and IL-6 production at 100 μM, and significantly suppresses TNF-α production at 10 and 100 μM[1].
    Ibudilast (1~100 μM; 48 hours; neuronal cells) significantly increases the neuronal survival rate. Ibudilast (1~100 μM; 48 hours; microglia) inhibits the production of superoxide and NO[1].
    Ibudilast upregulates the production of IL-10 in a dose-dependent manner. Ibudilast increases NGF mRNA and protein levels and GDNF and NT-4 mRNA expression. Ibudilast decreases the apoptotic changes observed in the neuronal cells in a dose-dependent manner[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Ibudilast 関連抗体

    Western Blot Analysis[1]

    Cell Line: Microglia
    Concentration: 1~100 μM
    Incubation Time: 24 hours
    Result: Suppressed both IL-1β and IL-6 production at 100 µM, and significantly suppresses TNF-α production at 10 and 100 µM.  
    臨床実験
    分子量

    230.31

    分子式

    C14H18N2O
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CC(C)C(C1=C2C=CC=CN2N=C1C(C)C)=O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : ≥ 140 mg/mL (607.88 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : < 0.1 mg/mL (insoluble)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.3420 mL 21.7099 mL 43.4197 mL
    5 mM 0.8684 mL 4.3420 mL 8.6839 mL
    10 mM 0.4342 mL 2.1710 mL 4.3420 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.67 mg/mL (11.59 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.67 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (26.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.67 mg/mL (11.59 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.67 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (26.7 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.87%

    COA (259 KB) HNMR (137 KB) LCMS (94 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 4.3420 mL 21.7099 mL 43.4197 mL 108.5493 mL
    5 mM 0.8684 mL 4.3420 mL 8.6839 mL 21.7099 mL
    10 mM 0.4342 mL 2.1710 mL 4.3420 mL 10.8549 mL
    15 mM 0.2895 mL 1.4473 mL 2.8946 mL 7.2366 mL
    20 mM 0.2171 mL 1.0855 mL 2.1710 mL 5.4275 mL
    25 mM 0.1737 mL 0.8684 mL 1.7368 mL 4.3420 mL
    30 mM 0.1447 mL 0.7237 mL 1.4473 mL 3.6183 mL
    40 mM 0.1085 mL 0.5427 mL 1.0855 mL 2.7137 mL
    50 mM 0.0868 mL 0.4342 mL 0.8684 mL 2.1710 mL
    60 mM 0.0724 mL 0.3618 mL 0.7237 mL 1.8092 mL
    80 mM 0.0543 mL 0.2714 mL 0.5427 mL 1.3569 mL
    100 mM 0.0434 mL 0.2171 mL 0.4342 mL 1.0855 mL
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Ibudilast Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ibudilast50847-11-5KC-404 AV-411 MN-166KC404KC 404AV411AV 411AV-411MN166MN 166MN-166Phosphodiesterase (PDE)cyclicAMPphosphodiesterasePDEplateletanti-aggregatoryasthmaInhibitorinhibitorinhibit

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    製品名:
    Ibudilast
    製品番号:
    HY-B0763
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