1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Lanosterol

Lanosterol 

Cat. No.: HY-W020033 Purity: ≥98.0%
Handling Instructions

Lanosterol is an intermediate of cholesterol synthesis and use of lanosterol induces ubiquitination and degradation of a rate-controlling enzyme of cholesterol synthesis, i.e., HMG CoA reductase. Lanosterol suppresses the aggregation and cytotoxicity of misfolded proteins linked with neurodegenerative diseases.

For research use only. We do not sell to patients.

Lanosterol Chemical Structure

Lanosterol Chemical Structure

CAS No. : 79-63-0

Size Price Stock Quantity
1 mg USD 60 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Lanosterol is an intermediate of cholesterol synthesis and use of lanosterol induces ubiquitination and degradation of a rate-controlling enzyme of cholesterol synthesis, i.e., HMG CoA reductase. Lanosterol suppresses the aggregation and cytotoxicity of misfolded proteins linked with neurodegenerative diseases[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Lanosterol diminishes aberrant proteotoxic aggregation and mitigates their cytotoxicity via induced expression of co-chaperone CHIP and elevated autophagy[1].
Lanosterol is a precursor of meiosis-activating sterols in the cholesterol biosynthetic pathway and induces a physiological signal that instructs the oocyte to reinitiate meiosis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

426.72

Formula

C₃₀H₅₀O

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 10 mg/mL (23.43 mM; ultrasonic and warming and heat to 60°C)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3435 mL 11.7173 mL 23.4346 mL
5 mM 0.4687 mL 2.3435 mL 4.6869 mL
10 mM 0.2343 mL 1.1717 mL 2.3435 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (2.34 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 1 mg/mL (2.34 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: ≥98.0%

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Product Name:
Lanosterol
Cat. No.:
HY-W020033
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