79-63-0
79-63-0
Chemical Structure
Lanosterol
- CAS No.: 79-63-0
- Formula:C30H50O
- Molecular Weight:426.72
IUPAC Name: (3S,5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-17-((R)-6-methylhept-5-en-2-yl)-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
InChIKey: CAHGCLMLTWQZNJ-BQNIITSRSA-N
SMILES: C[C@]12C3=C(CC[C@@]1([C@]([C@H](C)CC/C=C(C)/C)([H])CC2)C)[C@@]4([C@@](C(C)([C@@H](O)CC4)C)([H])CC3)C
Biological Activity: Lanosterol is an intermediate of cholesterol synthesis and use of lanosterol induces ubiquitination and degradation of a rate-controlling enzyme of cholesterol synthesis, i.e., HMG CoA reductase. Lanosterol suppresses the aggregation and cytotoxicity of misfolded proteins linked with neurodegenerative diseases[1][2].
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Lanosterol | 99.97% | Lanosterol is an intermediate of cholesterol synthesis and use of lanosterol induces ubiquitination and degradation of a rate-controlling enzyme of cholesterol synthesis, i.e., HMG CoA reductase. Lanosterol suppresses the aggregation and cytotoxicity of misfolded proteins linked with neurodegenerative diseases. | ||||||||||||||||||||
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Lanosterol (Standard) | 99.21% | Lanosterol (Standard) is the analytical standard of Lanosterol. This product is intended for research and analytical applications. Lanosterol is an intermediate of cholesterol synthesis and use of lanosterol induces ubiquitination and degradation of a rate-controlling enzyme of cholesterol synthesis, i.e., HMG CoA reductase. Lanosterol suppresses the aggregation and cytotoxicity of misfolded proteins linked with neurodegenerative diseases. | ||||||||||||||||||||
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Inotodiol | 98.29% | Inotodiol activates p53 signaling pathway, inhibits MMP-2/9, and exhibits antitumor activity in cancer cell HeLa. Inotodiol inhibits the generation of ROS and exhibits antioxidant and neuroprotective effects. Inotodiol inhibits the activation of MAPK and NF-κB signaling pathway, and exhibits anti-inflammatory activity. Inotodiol inhibits TLR-4 mediated TNF-α production (IC50s in BMMC and BMDM is 0.7 μM and 3.0 μM), inhibits the degranulation in mast cell, exhibits anti-allergic activity. Inotodiol is orally active. | ||||||||||||||||||||
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Dihydrolanosterol (Standard) | ≥98% | Dihydrolanosterol (Standard) is the analytical standard of Dihydrolanosterol (HY-122410). This product is intended for research and analytical applications. Dihydrolanosterol is a subtrate of CYP51 and a cholesterol biosynthesis inhibitor.. | ||||||||||||||||||||
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Euphorbadienol | Euphorbadienol (alpha-Euphorbol), a triterpenic compound, isolated from the latex of Euphorbia resinifera. The derivatives of Euphorbadienol can be used as elicitors of disease resistance, and has antileishmanial and antitrypanosomal activity. | |||||||||||||||||||||
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Euphol (Standard) | ≥98% | Euphol (Standard) is the analytical standard of Euphol. This product is intended for research and analytical applications. Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC50=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain. | ||||||||||||||||||||
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Uvariol | Uvariol (21-Hydroxylanosterol) is a natural product that can be isolated from the roots of Piptostigma fugax. | |||||||||||||||||||||
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3β-Hydroxylanosta-8,24-dien-21-al | 98.46% | 3β-Hydroxylanosta-8,24-dien-21-al is a lanostane-type triterpene. 3β-Hydroxylanosta-8,24-dien-21-al can inhibit the tumor promotion, reducing the percentage of mice bearing papillomas. | ||||||||||||||||||||
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Euphenol | Euphenol (Dihydroeuphol) is a synthetic triterpene and a derivative of Euphol (HY-N0313). | |||||||||||||||||||||
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22-Epiinotodiol | 22-Epiinotodiol ((3β,22S)-Lanosta-8,24-diene-3,22-diol) is a natural triterpene. | |||||||||||||||||||||
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Tirucallol | 99.77% | Tirucallol, a tetracyclic triterpene, is isolated from Euphorbia lacteal latex. Tirucallol has topical anti-inflammatory effect. Tirucallol can suppress ear edema in the mouse model and inhibit nitrite production in lipopolysaccharide-stimulated macrophages. | ||||||||||||||||||||
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24,25-Dihydrolanosterol | 99.68% | 24,25-Dihydrolanosterol is a naturally occurring tetracyclic Δ8-triterpene alcohol that can be found in the seeds of Capsicum annuum. 24,25-Dihydrolanosterol is the initial carbocyclic sterol precursor in animals, fungi, and trypanosomatids, and participates in sterol synthesis. | ||||||||||||||||||||
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References
- [1]. Upadhyay A, et al. Lanosterol Suppresses the Aggregation and Cytotoxicity of Misfolded Proteins Linked with Neurodegenerative Diseases. Mol Neurobiol. 2018;55(2):1169-1182. [Content Brief]
- [2]. Lee S, et al. Lanosterol influences cytoplasmic maturation of pig oocytes in vitro and improves preimplantation development of cloned embryos. Theriogenology. 2016;85(4):575-584. [Content Brief]
