2. GPCR/G Protein MAPK/ERK Pathway Apoptosis
  3. Ras Apoptosis
  4. ML141

ML141 (CID-2950007) is a potent, allosteric, selective and reversible non-competitive inhibitor of Cdc42 GTPase. ML141 inhibits Cdc42 wild type and Cdc42 Q61L mutant with EC50s of 2.1 and 2.6 μM, respectively. ML141 shows low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 do not show cytotoxicity in multiple cell lines.

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CAS 番号 : 71203-35-5

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 101 在庫あり
Solution
10 mM * 1 mL in DMSO USD 101 在庫あり
Solid
1 mg $43 在庫あり
5 mg $92 在庫あり
10 mg $135 在庫あり
25 mg $270 在庫あり
50 mg $432 在庫あり
100 mg $691 在庫あり
500 mg $1320 在庫あり
1 g $1950 在庫あり
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10 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 32 publication(s) in Google Scholar

ML141 関連抗体

Top Publications Citing Use of Products
IF
IHC
Cell Imaging/Staining
Bio/Physico-chemical Assay

    ML141 purchased from MedChemExpress. Usage Cited in: Angiogenesis. 2025 Aug 20;28(4):44.  [Abstract]

    In the MY-1 group, cells at the wound edge extended filopodia in the direction of migration, while in the presence of ML141, filopodia formation was suppressed, and MY-1 could not reverse the inhibitory effect of ML141 (10 μM).

    ML141 purchased from MedChemExpress. Usage Cited in: Angiogenesis. 2025 Aug 20;28(4):44.  [Abstract]

    Treatment with ML141 reduced the primary tube length, node count, network formation in the tube formation assay and the number of migrated cells in the Transwell assay. Similarly, MY-1 could not reverse the inhibitory effect of ML141(10 μM).

    ML141 purchased from MedChemExpress. Usage Cited in: Hum Reprod. 2024 Nov 1:deae246.  [Abstract]

    ML141 (10 μM)-treated primary EnSCs remained spindle-shaped fibroblast-like cells after decidualization stimulation, without an obvious change in cell size

    ML141 purchased from MedChemExpress. Usage Cited in: Hum Reprod. 2024 Nov 1:deae246.  [Abstract]

    ML141 (10μM) treatment hindered the upregulation of sST2 without affecting the secretion of CLU.

    ML141 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Jan 30;14(1):478.  [Abstract]

    Treatment with Cdc42 inhibitor ML141 (5 µM) disassembled SCVs giving rise to increased proportion of dispersive SCV in wild-type, but not in vimentin KO cells.

    Ras アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    K-Ras H-Ras N-Ras Ras

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    • 純度とドキュメンテーション

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    製品説明

    ML141 (CID-2950007) is a potent, allosteric, selective and reversible non-competitive inhibitor of Cdc42 GTPase. ML141 inhibits Cdc42 wild type and Cdc42 Q61L mutant with EC50s of 2.1 and 2.6 μM, respectively. ML141 shows low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 do not show cytotoxicity in multiple cell lines[1][2].

    体外実験

    ML141 (CID-2950007) is not cytotoxic in either cell line at doses of 0.1-3 μM after treatment for 4 days. OVCA429 cells were insensitive to 10 μM compound, whereas some cytotoxicity was observed in SKOV3ip cells at this concentration after a 4-day treatment, although it did not reach statistical significance. ML141 is not cytotoxic toward Swiss 3T3 or Vero E6 cells up to 10 μM for 24 and 48 h, respectively[1].
    ML141 inhibits 3T3 fibroblast filopodia formation and inhibits ovarian cancer cell migration[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    ML141 関連抗体
    体内実験

    ML141 (CID-2950007) (10 μM; intracerebroventricular injection) causes acute anxiety in mice[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: C57Bl/6J mice[3]
    Dosage: 10 µM
    Administration: Intracerebroventricular injection
    Result: Increased anxiety in mice.
    分子量

    407.49

    分子式

    C22H21N3O3S
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=S(C1=CC=C(N2N=C(C3=CC=CC=C3)CC2C4=CC=C(OC)C=C4)C=C1)(N)=O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (245.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4540 mL 12.2702 mL 24.5405 mL
    5 mM 0.4908 mL 2.4540 mL 4.9081 mL
    10 mM 0.2454 mL 1.2270 mL 2.4540 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

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    濃度 （終了）

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    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (6.14 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    • Protocol 2

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: 2.08 mg/mL (5.10 mM); Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.96%

    COA (254 KB) HNMR (254 KB) RP-HPLC (246 KB) MS (68 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.4540 mL 12.2702 mL 24.5405 mL 61.3512 mL
    5 mM 0.4908 mL 2.4540 mL 4.9081 mL 12.2702 mL
    10 mM 0.2454 mL 1.2270 mL 2.4540 mL 6.1351 mL
    15 mM 0.1636 mL 0.8180 mL 1.6360 mL 4.0901 mL
    20 mM 0.1227 mL 0.6135 mL 1.2270 mL 3.0676 mL
    25 mM 0.0982 mL 0.4908 mL 0.9816 mL 2.4540 mL
    30 mM 0.0818 mL 0.4090 mL 0.8180 mL 2.0450 mL
    40 mM 0.0614 mL 0.3068 mL 0.6135 mL 1.5338 mL
    50 mM 0.0491 mL 0.2454 mL 0.4908 mL 1.2270 mL
    60 mM 0.0409 mL 0.2045 mL 0.4090 mL 1.0225 mL
    80 mM 0.0307 mL 0.1534 mL 0.3068 mL 0.7669 mL
    100 mM 0.0245 mL 0.1227 mL 0.2454 mL 0.6135 mL
    • No file chosen (Maximum size is: 1024 Kb)
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    ML141 Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    ML14171203-35-5CID-2950007ML 141ML-141CID2950007CID 2950007RasApoptosistoxicitynoncompetitiveallostericovariancanceracuteanxietyOVCA429cellsInhibitorinhibitorinhibit

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    製品名:
    ML141
    製品番号:
    HY-12755
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