2. Anti-infection
  3. Bacterial Antibiotic
  4. Netilmicin sulfate

Netilmicin (sulfate)  (Synonyms: SCH-20569 (sulfate); 硫酸ネチルマイシン)

製品番号: HY-A0086 純度: 98.0%
COA 取扱説明書 Technical Support

Netilmicin (Sch 20569) sulfate is a broad-spectrum semisynthetic aminoglycoside antibiotic. Netilmicin sulfate exhibits antibacterial activity against aminoglycoside-susceptible gram-negative strains and aminoglycoside-resistant strain, such as Escherichia coli, Pseudomonas aeruginosa, Proteus, Staphylococcus aureus, Streptococcus, Serratia, and Enterobacter, with MIC of 0.125-8 μg/mL.

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Netilmicin sulfate

Netilmicin (sulfate) 構造式

CAS 番号 : 56391-57-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 82 在庫あり
Solution
10 mM * 1 mL in Water USD 82 在庫あり
Solid
5 mg $52 在庫あり
10 mg $78 在庫あり
25 mg $147 在庫あり
50 mg $207 在庫あり
100 mg $290 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Other Forms of Netilmicin sulfate:

Netilmicin (sulfate) 関連抗体

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  • 純度とドキュメンテーション

  • 参考文献

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製品説明

Netilmicin (Sch 20569) sulfate is a broad-spectrum semisynthetic aminoglycoside antibiotic. Netilmicin sulfate exhibits antibacterial activity against aminoglycoside-susceptible gram-negative strains and aminoglycoside-resistant strain, such as Escherichia coli, Pseudomonas aeruginosa, Proteus, Staphylococcus aureus, Streptococcus, Serratia, and Enterobacter, with MIC of 0.125-8 μg/mL[1].

IC50 & Target

Aminoglycoside

 

体外実験

Netilmicin sulfate exhibits antibacterial activity against aminoglycoside-susceptible gram-negative strains and aminoglycoside-resistant strain, such as Escherichia coli, Pseudomonas aeruginosa, Proteus, Staphylococcus aureus, Streptococcus, Serratia, and Enterobacter, with MIC of 0.125-8 μg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Netilmicin (sulfate) 関連抗体
体内実験

Netilmicin (PD50: <0.25->50 mg/kg; s.c.; once; 1 h after infection) sulfate shows in vivo antibacterial activity against many clinically important bacteria in CF1 mice, especially against strains resistant to Gentamicin (HY-A0276A) and Tobramycin (HY-B0441) that produce the adenylating enzyme ANT (2")[1].
Netilmicin (i.v.: LD50 of 40 mg/kg; i.p.: LD50 of 125 mg/kg; s.c.: LD50 of 175 mg/kg) sulfate has a higher acute toxicity than Gentamicin in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
分子量

720.78

分子式

C21H41N5O7.5/2H2SO4
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

NCC1=CC[C@@H](N)[C@](O[C@@H]2[C@@H](N)C[C@@H](NCC)[C@H](O[C@@]3([H])OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H]2O)([H])O1.[2.5H2SO4]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : 100 mg/mL (138.74 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3874 mL 6.9369 mL 13.8739 mL
5 mM 0.2775 mL 1.3874 mL 2.7748 mL
10 mM 0.1387 mL 0.6937 mL 1.3874 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (69.37 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.3874 mL 6.9369 mL 13.8739 mL 34.6846 mL
5 mM 0.2775 mL 1.3874 mL 2.7748 mL 6.9369 mL
10 mM 0.1387 mL 0.6937 mL 1.3874 mL 3.4685 mL
15 mM 0.0925 mL 0.4625 mL 0.9249 mL 2.3123 mL
20 mM 0.0694 mL 0.3468 mL 0.6937 mL 1.7342 mL
25 mM 0.0555 mL 0.2775 mL 0.5550 mL 1.3874 mL
30 mM 0.0462 mL 0.2312 mL 0.4625 mL 1.1562 mL
40 mM 0.0347 mL 0.1734 mL 0.3468 mL 0.8671 mL
50 mM 0.0277 mL 0.1387 mL 0.2775 mL 0.6937 mL
60 mM 0.0231 mL 0.1156 mL 0.2312 mL 0.5781 mL
80 mM 0.0173 mL 0.0867 mL 0.1734 mL 0.4336 mL
100 mM 0.0139 mL 0.0694 mL 0.1387 mL 0.3468 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Netilmicin sulfate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Netilmicin56391-57-2SCH-20569SCH20569SCH 20569BacterialAntibioticInhibitorinhibitorinhibit

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