2. GPCR/G Protein Neuronal Signaling Stem Cell/Wnt MAPK/ERK Pathway
  3. Adrenergic Receptor ERK
  4. Salbutamol

サルブタモール  (Synonyms: Salbutamol; Albuterol; AH-3365)

製品番号: HY-B1037 純度: 99.53%
COA 取扱説明書 Technical Support

Salbutamol (Albuterol) is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease.

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CAS 番号 : 18559-94-9

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in DMSO USD 55 在庫あり
Solid
100 mg $50 在庫あり
250 mg $75 在庫あり
500 mg $100 在庫あり
1 g $135 在庫あり
5 g   お問い合わせ  
10 g   お問い合わせ  

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カスタマーレビュー

Based on 7 publication(s) in Google Scholar

Other Forms of Salbutamol:

サルブタモール 関連抗体

Top Publications Citing Use of Products

    Salbutamol purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393.  [Abstract]

    Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) significantly decreased both ovarian weight and the number of primordial follicles in C57BL/6J mice, along with a declining trend in the total follicle count.

    Salbutamol purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393.  [Abstract]

    Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) led to the upregulation of ADRB2 receptor expression in the granulosa cells of ovarian tissue in C57BL/6J mice.

    Salbutamol purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393.  [Abstract]

    Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) significantly increased the protein expression levels of KIT and KITL in the ovarian tissue in C57BL/6J mice.

    Salbutamol purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393.  [Abstract]

    Salbutamol (SAL) (100 µM; 24 h) considerably increased the mRNA expression level of KITL in the ovarian granulosa cell line KGN.

    Salbutamol purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393.  [Abstract]

    Salbutamol (SAL) (100 µM; 24 h) increased the cAMP concentration in KGN cells.

    Adrenergic Receptor アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    α adrenergic receptor β adrenergic receptor

    ERK アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    ERK ERK1 ERK2 ERK5 ERK8

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Salbutamol (Albuterol) is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease[1][2].

    IC50 & Target[1]

    β adrenergic receptor

     

    Cellular Effect
    Cell Line Type Value Description References
    Sf9 IC50
    0.98 3
    Compound: (rac)-4
    Displacement of [3H]CGP1217 from human recombinant adrenergic beta2 receptor transfected in insect Sf9 cells by scintillation counting
    Displacement of [3H]CGP1217 from human recombinant adrenergic beta2 receptor transfected in insect Sf9 cells by scintillation counting
    		[PMID: 19245211]
    Sf9 IC50
    0.98 3
    Compound: (rac)-4
    Displacement of [3H]CGP1217 from human recombinant adrenergic beta2 receptor transfected in insect Sf9 cells by scintillation counting
    Displacement of [3H]CGP1217 from human recombinant adrenergic beta2 receptor transfected in insect Sf9 cells by scintillation counting
    		[PMID: 19245211]
    Sf9 IC50
    0.98 3
    Compound: (rac)-4
    Displacement of [3H]CGP1217 from human recombinant adrenergic beta2 receptor transfected in insect Sf9 cells by scintillation counting
    Displacement of [3H]CGP1217 from human recombinant adrenergic beta2 receptor transfected in insect Sf9 cells by scintillation counting
    		[PMID: 19245211]
    体外実験

    Salbutamol (16 μM; 24 h) significantly induces EMT, migration and invasion by ERK (extracellular signal-regulated kinase) phosphorylation in gastric cancer cells[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    サルブタモール 関連抗体

    Western Blot Analysis[1]

    Cell Line: MGC803, SGC7901
    Concentration: 16 μM
    Incubation Time: 24 h
    Result: Increased β2-AR and ERK levels.
    Upregulated mesenchymal markers, CDH2 (N-cadherin) and Snail expression, and decreased the expression of epithelial marker CDH1 (E-cadherin).
    体内実験

    Salbutamol (5 mg/kg; oral administration; 2 weeks) can increase tumor growth in nude mice with gastric cancer[1].
    Salbutamol (6 mg/kg; oral administration; 4 weeks) has a significant protective effect against Streptozotocin (HY-13753)-induced skeletal muscle atrophy in diabetic rats[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Streptozotocin induced diabetic rats[2]
    Dosage: 6 mg/kg
    Administration: Oral administration (p.o.); 4 weeks
    Result: Enhanced muscle grip strength, coordination, and antioxidant levels.
    Reduced proinflammatory markers and oxidative stress.
    Reduced serum muscle biomarkers.
    Increased testosterone, restored lipidemic levels, and improved muscle cellular architecture.
    臨床実験
    分子量

    239.31

    分子式

    C13H21NO3
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OC(CNC(C)(C)C)C1=CC=C(O)C(CO)=C1
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (417.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.1787 mL 20.8934 mL 41.7868 mL
    5 mM 0.8357 mL 4.1787 mL 8.3574 mL
    10 mM 0.4179 mL 2.0893 mL 4.1787 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

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    体積 （終了）

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    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (10.45 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (10.45 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.53%

    COA (245 KB) HNMR (133 KB) LCMS (86 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 4.1787 mL 20.8934 mL 41.7868 mL 104.4670 mL
    5 mM 0.8357 mL 4.1787 mL 8.3574 mL 20.8934 mL
    10 mM 0.4179 mL 2.0893 mL 4.1787 mL 10.4467 mL
    15 mM 0.2786 mL 1.3929 mL 2.7858 mL 6.9645 mL
    20 mM 0.2089 mL 1.0447 mL 2.0893 mL 5.2234 mL
    25 mM 0.1671 mL 0.8357 mL 1.6715 mL 4.1787 mL
    30 mM 0.1393 mL 0.6964 mL 1.3929 mL 3.4822 mL
    40 mM 0.1045 mL 0.5223 mL 1.0447 mL 2.6117 mL
    50 mM 0.0836 mL 0.4179 mL 0.8357 mL 2.0893 mL
    60 mM 0.0696 mL 0.3482 mL 0.6964 mL 1.7411 mL
    80 mM 0.0522 mL 0.2612 mL 0.5223 mL 1.3058 mL
    100 mM 0.0418 mL 0.2089 mL 0.4179 mL 1.0447 mL
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Salbutamol Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Salbutamol18559-94-9Albuterol AH-3365AH3365AH 3365AH-3365Adrenergic ReceptorERKBeta ReceptorExtracellular signal regulated kinasesβ2-ARAgonistMGC803SGC7901COPDInhibitorinhibitorinhibit

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    製品番号:
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