2. Signaling Pathways
  3. NF-κB
  4. NF-κB
  5. NF-κB Isoform
  6. NF-κB Inhibitor

NF-κB Inhibitor

NF-κB Inhibitors (254):

Cat. No. Product Name Effect Purity
  • HY-10227
    Bortezomib
    		Inhibitor 99.97%
    Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue.
  • HY-100487
    TAK-243
    		Inhibitor 98.38%
    TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination.
  • HY-13453
    BAY 11-7082
    		Inhibitor 99.98%
    BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor.
  • HY-13982
    JSH-23
    		Inhibitor 99.11%
    JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC50 of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7.
  • HY-112433
    NIK SMI1
    		Inhibitor 99.69%
    NIK SMI1 is a potent, selective NF-κB inducing kinase (NIK) inhibitor, which inhibits NIK-catalyzed hydrolysis of ATP to ADP with IC50 of 0.23±0.17 nM.
  • HY-N0141
    Parthenolide
    		Inhibitor 98.54%
    Parthenolide is an NF-κB inhibitor, reduces histone deacetylase 1 (HDAC-1) and DNA methyltransferase 1 independent of NF-κB inhibition.
  • HY-N2117
    Isoginkgetin
    		Inhibitor 99.73%
    Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor.
  • HY-120501
    B022
    		Inhibitor 99.76%
    B022 is a potent and selective NF-κB-inducing kinase (NIK) inhibitor (Ki of 4.2 nM; IC50=15.1 nM).
  • HY-N0822
    Shikonin
    		Inhibitor 99.80%
    Shikonin is a major component of a Chinese herbal medicine named zicao.
  • HY-18935A
    CBL0137 hydrochloride
    		Inhibitor 99.66%
    CBL0137 hydrochloride is an inhibitor of the histone chaperone, FACT.
  • HY-130603
    DCZ0415
    		Inhibitor 99.77%
    DCZ0415, a potent TRIP13 inhibitor, impairs nonhomologous end joining repair and inhibits NF-κB activity.
  • HY-10257
    BAY 11-7085
    		Inhibitor 99.99%
    BAY 11-7085 (BAY 11-7083) is an inhibitor of NF-κB activation and phosphorylation of IκBα; it stabilizes IκBα with an IC50 of 10 μM.
  • HY-N2065
    Withaferin A
    		Inhibitor 99.92%
    Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities.
  • HY-P0151
    SN50
    		Inhibitor 98.61%
    SN50 is a cell permeable inhibitor of NF-κB translocation.
  • HY-P3229
    SN52
    		Inhibitor 98.24%
    SN52 is a potent, competitive, and cell-permeable inhibitor of NF-κB2.
  • HY-N0375
    18α-Glycyrrhetinic acid
    		Inhibitor 99.32%
    18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism.
  • HY-13812
    QNZ
    		Inhibitor 99.51%
    QNZ (EVP4593) shows strong inhibitory effects on NF-κB transcriptional activation and TNF-α production with IC50s of 11 and 7 nM, respectively.
  • HY-16172
    DMAPT
    		Inhibitor ≥98.0%
    DMAPT (Dimethylamino Parthenolide), an analogue of Parthenolide (PTL), is an oral active NF-κB inhibitor, with a LD50 of 1.7 μM for cell population in AML cells.
  • HY-N0197
    Baicalin
    		Inhibitor 99.17%
    Baicalin, as a flavonoid glycoside, is an allosteric carnitine palmityl transferase 1 (CPT1) activator.
  • HY-10454
    Delanzomib
    		Inhibitor ≥98.0%
    Delanzomib (CEP-18770) is a potent and orally active chymotrypsin-like activity of the proteasome inhibitor with an IC50 of 3.8 nM.