2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Epigenetics
  4. Sirtuin

Sirtuin

Sirtuin

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Sirtuin (Sir2 proteins) are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in bacteria, archaeaand eukaryotes. Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Sirtuins can also control circadian clocks and mitochondrial biogenesis.

Sirtuin Isoform Specific Products:

Sirtuin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-101465
    AK-1
    		Inhibitor 99.84%
    AK-1 is a potent, specific and cell-permeable SIRT2 inhibitor, with an IC50 of 12.5 μM.
    AK-1
  • HY-169934
    SIRT1-IN-4
    		Inhibitor 98.62%
    SIRT1-IN-4 (Compound 8c) is a SIRT1 inhibitor, with an IC50 of 10.04 μM. SIRT1-IN-4 can be used for the research of cancer.
    SIRT1-IN-4
  • HY-124113
    4'-Bromo-resveratrol
    		Inhibitor 99.94%
    4'-Bromo-resveratrol (4′‐BR) is a dual SIRT1/SIRT3 inhibitor with an IC50 of 0.2 mM for both targets. 4'-Bromo-resveratrol induces caspase-dependent apoptosis, induces G0/G1 cell cycle arrest, and inhiibits proliferation. 4'-Bromo-resveratrol reduces lactate production, glucose uptake, and NAD+/NADH ratio, and downregulates lactate dehydrogenase A and glucose transporter 1 (GLUT1). 4'-Bromo-resveratrol can be used for the research of melanoma.
    4'-Bromo-resveratrol
  • HY-15452A
    (S)-Selisistat
    		Inhibitor 99.39%
    (S)-Selisistat ((S)-EX-527) is a potent and selective SIRT1 inhibitor, with an IC50 of 98 nM.
    (S)-Selisistat
  • HY-161920
    SIRT3-IN-1
    		Inhibitor 98.47%
    SIRT3-IN-1 (compound 17f) is a SIRT3 inhibitor, with IC50 of 0.043 μM. SIRT3-IN-1 can be used in the research of acute leukemia (AML).
    SIRT3-IN-1
  • HY-RS12950
    SIRT6 Human Pre-designed siRNA Set A
    		Inhibitor

    SIRT6 Human Pre-designed siRNA Set A contains three designed siRNAs for SIRT6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    SIRT6 Human Pre-designed siRNA Set A
  • HY-112428
    Sirt2-IN-2
    		Inhibitor 99.80%
    Sirt2-IN-2 (Compound 10) is a selective Sirt2 inhibitor with an IC50 of 0.118 μM.
    Sirt2-IN-2
  • HY-16615
    SIRT-IN-1
    		Inhibitor 98.14%
    SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 nM, respectively.
    SIRT-IN-1
  • HY-NP019
    Agkistrodon halys batroxobin
    		Inhibitor
    Agkistrodon halys batroxobin is a thrombin-like serine protease. Agkistrodon halys batroxobin reduces the expression of Sirt1 and extracellular signal-regulated kinase activation in brain tissue. Agkistrodon halys batroxobin reduces cleaved caspase-3 expression and inhibits neuronal apoptosis in rat.
    Agkistrodon halys batroxobin
  • HY-112427
    Sirt2-IN-1
    		Inhibitor 98.71%
    Sirt2-IN-1 (Compound 9) is a sirtuin 2 (Sirt2) inhibitor with an IC50 of 163 nM.
    Sirt2-IN-1
  • HY-B0150S2
    Nicotinamide-13C6
    		Inhibitor 99.8%
    Nicotinamide-13C6 is the 13C-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
    Nicotinamide-<sup>13</sup>C<sub>6</sub>
  • HY-RS12943
    SIRT3 Human Pre-designed siRNA Set A
    		Inhibitor

    SIRT3 Human Pre-designed siRNA Set A contains three designed siRNAs for SIRT3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    SIRT3 Human Pre-designed siRNA Set A
  • HY-107660
    SIRT2-IN-8
    		Inhibitor 98.45%
    SIRT2-IN-8 is a potent SIRT2 inhibitor. SIRT2-IN-8 can be used for Huntington’s and Parkinson’s diseases research.
    SIRT2-IN-8
  • HY-111522
    RK-9123016
    		Inhibitor 99.65%
    RK-9123016 is a potent inhibitor of SIRT2. RK-9123016 inhibits the enzymatic activity of SIRT2 with an IC50 value of 0.18 µM but not other human sirtuin members including SIRT1 and SIRT3 at 100 µM. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression.
    RK-9123016
  • HY-RS12947
    SIRT5 Human Pre-designed siRNA Set A
    		Inhibitor

    SIRT5 Human Pre-designed siRNA Set A contains three designed siRNAs for SIRT5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    SIRT5 Human Pre-designed siRNA Set A
  • HY-123653
    SirReal-1
    		Inhibitor 99.82%
    SirReal-1 is a potent and selective Sirt2 inhibitor (IC50 = 3.7 μM).
    SirReal-1
  • HY-146689
    SIRT1-IN-2
    		Inhibitor 98.31%
    SIRT1-IN-2 (compound 3h) is a potent and selective SIRT1 (silent information regulator 1) inhibitor, with an IC50 of 1.6 μM.
    SIRT1-IN-2
  • HY-156027
    SIRT6-IN-3
    		Inhibitor 98.19%
    SIRT6-IN-3 (compound 8a) is a selective inhibitor of SIRT6 (IC50=7.49 μM). SIRT6-IN-3 inhibits pancreatic ductal adenocarcinoma (PDAC) cells proliferation and induces apoptosis. SIRT6-IN-3 increases the sensitivity of cancer cells to gemcitabine (HY-17026) via blocking the DNA damage repair pathway. SIRT6-IN-3 is used in pancreatic cancer research.
    SIRT6-IN-3
  • HY-149426
    SIRT5 inhibitor 7
    		Inhibitor 99.63%
    SIRT5 inhibitor 7 (compound 58) is a substrate-competitive and selective SIRT5 inhibitor with anti-inflammatory activity. SIRT5 inhibitor 7 has renal protective effects and regulates protein succinylation and the release of pro-inflammatory cytokines. SIRT5 inhibitor 7 has in vivo activity in AKI mouse models of lipopolysaccharide (LPS) and cecal ligation/perforation (CLP)-induced sepsis-related acute kidney injury.
    SIRT5 inhibitor 7
  • HY-146690
    SIRT1-IN-3
    		Inhibitor 99.12%
    SIRT1-IN-3 (compound 3j) is a potent and selective SIRT1 inhibitor, with an IC50 of 4.2 μM.
    SIRT1-IN-3
Cat. No. Product Name / Synonyms Application Reactivity
Sirtuin Isoform Comparison

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