Cat. No.: HY-124113

4'-Bromo-resveratrol

(Synonyms: 4′‐BR)

Customer Review

Based on 1 Customer Validation

4'-Bromo-resveratrol (4′‐BR) is a dual SIRT1/SIRT3 inhibitor with an IC₅₀ of 0.2 mM for both targets. 4'-Bromo-resveratrol induces caspase-dependent apoptosis, induces G0/G1 cell cycle arrest, and inhiibits proliferation. 4'-Bromo-resveratrol reduces lactate production, glucose uptake, and NAD⁺/NADH ratio, and downregulates lactate dehydrogenase A and glucose transporter 1 (GLUT1). 4'-Bromo-resveratrol can be used for the research of melanoma.

For research use only. We do not sell to patients.

Purity: 99.94%
CAS No.: 1224713-90-9
Formula: C₁₄H₁₁BrO₂
Molecular Weight:291.14

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

4'-Bromo-resveratrol Chemical Structure

CAS No.: 1224713-90-9

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

SIRT1

0.2 mM (IC₅₀)

SIRT3

0.2 mM (IC₅₀)

Caspase 3

Caspase 8

GLUT1

LDHA

All Sirtuin Isoforms :

All Caspase Isoforms :

All GLUT Isoforms :

In Vitro

4'-Bromo-resveratrol (0.0125-0.2 mM; 24-72 h) dose- and time-dependently inhibits proliferation and viability of G361, SK-MEL-28, and SK-MEL-2 human melanoma cells^[1].
4'-Bromo-resveratrol (0.0125-0.2 mM; 48 h) dose-dependently impairs clonogenic survival of G361, SK-MEL-28, and SK-MEL-2 human melanoma cells^[1].
4'-Bromo-resveratrol (0.0125-0.05 mM; 24-72 h) dose- and time-dependently induces apoptosis in G361, SK-MEL-28, and SK-MEL-2 human melanoma cells, inducing apoptotic morphological changes, including nuclear condensation and fragmentation^[1].
4'-Bromo-resveratrol (0.05 mM; 48 h) mediates G0/G1 phase arrest in G361, SK-MEL-28, and SK-MEL-2 human melanoma cells via P21-induced inhibition of Cyclin D1 and CDK6 after 48 hours of treatment^[1].
4'-Bromo-resveratrol (0.05 mM; 48 h) reduces expression of glycolysis-related proteins LDHA and GLUT1 in G361, SK-MEL-28, and SK-MEL-2 human melanoma cells after 48 hours of treatment^[1].
4'-Bromo-resveratrol (0.05 mM; 48 h) significantly inhibits migration of G361, SK-MEL-28, and SK-MEL-2 human melanoma cells^[1].
4'-Bromo-resveratrol (0.025-0.05 mM; 48 h) dose-dependently inhibits aerobic glycolysis in G361, SK-MEL-28, and SK-MEL-2 human melanoma cells, reducing lactate production, glucose uptake, and NAD⁺/NADH ratio^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

G361, SK-MEL-28, SK-MEL-2 cells
Concentration:

0.0125, 0.025, 0.05, 0.1, 0.2 mM
Incubation Time:

24 h, 48 h, 72 h
Result:

Inhibited melanoma cell proliferation and viability in a dose- and time-dependent manner.
Caused massive reduction in proliferation at 0.1 mM and 0.2 mM.
Induced appreciable growth inhibition at 0.025 mM, with statistically significant differences compared to vehicle control.

Apoptosis Analysis^[1]

Cell Line:

G361, SK-MEL-28, SK-MEL-2
Concentration:

0.0125, 0.025, 0.05 mM
Incubation Time:

24 h, 48 h, 72 h
Result:

Increased the percentage of apoptotic cells across all three melanoma cell lines in a dose- and time-dependent manner.
Showed statistically significant differences compared to vehicle control.

Western Blot Analysis^[1]

Cell Line:

G361, SK-MEL-28, SK-MEL-2
Concentration:

0.05 mM
Incubation Time:

48 h
Result:

Decreased protein levels of procaspase-3 and procaspase-8.
Increased levels of cleaved caspase-3.
Induced cleavage of full-length PARP (116 kDa) to its 89 kDa cleaved product.
Significantly diminished expression of PCNA across all three melanoma cell lines.\nAttenuated protein levels of Cyclin D1 and CDK6 across all three melanoma cell lines.
Induced expression of the CDK inhibitor P21 across all three melanoma cell lines.\nSignificantly decreased protein levels of lactate dehydrogenase A (LDHA) across all three melanoma cell lines.
Reduced expression of glucose transporter 1 (GLUT1) across all three melanoma cell lines.

Cell Cycle Analysis^[1]

Cell Line:

G361, SK-MEL-28, SK-MEL-2
Concentration:

0.05 mM
Incubation Time:

48 h
Result:

Caused a significant increase in the percentage of cells in the G0/G1 phase across all three melanoma cell lines.
Induced a concomitant decrease in the G2/M phase population across all three melanoma cell lines.
Showed statistically significant differences compared to vehicle control.

Chemical Information

CAS No. 1224713-90-9
Appearance Solid
Molecular Weight 291.14
Formula C₁₄H₁₁BrO₂
Color White to off-white
SMILES

OC1=CC(O)=CC(/C=C/C2=CC=C(C=C2)Br)=C1
Synonyms

4′‐BR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (858.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.4348 mL

17.1739 mL

34.3477 mL

5 mM

0.6870 mL

3.4348 mL

6.8695 mL

10 mM

0.3435 mL

1.7174 mL

3.4348 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (453 KB)
- English - EN (453 KB)
- Français - FR (453 KB)
- Deutsch - DE (453 KB)
- Norwegian - NO (453 KB)
- Español - ES (453 KB)
- Swedish - SV (453 KB)
- Italian - IT (453 KB)
- Korean - KR (453 KB)
- Portuguese - PT (453 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. George J, et al. 4'-Bromo-resveratrol, a dual Sirtuin-1 and Sirtuin-3 inhibitor, inhibits melanoma cell growth through mitochondrial metabolic reprogramming. Mol Carcinog. 2019;58(10):1876-1885. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.4348 mL	17.1739 mL	34.3477 mL	85.8693 mL
	5 mM	0.6870 mL	3.4348 mL	6.8695 mL	17.1739 mL
	10 mM	0.3435 mL	1.7174 mL	3.4348 mL	8.5869 mL
	15 mM	0.2290 mL	1.1449 mL	2.2898 mL	5.7246 mL
	20 mM	0.1717 mL	0.8587 mL	1.7174 mL	4.2935 mL
	25 mM	0.1374 mL	0.6870 mL	1.3739 mL	3.4348 mL
	30 mM	0.1145 mL	0.5725 mL	1.1449 mL	2.8623 mL
	40 mM	0.0859 mL	0.4293 mL	0.8587 mL	2.1467 mL
	50 mM	0.0687 mL	0.3435 mL	0.6870 mL	1.7174 mL
	60 mM	0.0572 mL	0.2862 mL	0.5725 mL	1.4312 mL
	80 mM	0.0429 mL	0.2147 mL	0.4293 mL	1.0734 mL
	100 mM	0.0343 mL	0.1717 mL	0.3435 mL	0.8587 mL

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

4'-Bromo-resveratrol

Bioactive Compound Library Max

Bioactive Compound Library

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

Immunology/Inflammation Compound Library

Membrane Transporter/Ion Channel Compound Library

Metabolism/Protease Compound Library

Histone Modification Research Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Glycolysis Compound Library

Pyroptosis Compound Library

Glutamine Metabolism Compound Library

Anti-Cancer Metabolism Compound Library

Glucose Metabolism Compound Library

Metabolic Enzyme Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cell Death Library

Multi-Target Compound Library

Radioprotector Library

MCE Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

Lactic Acid Metabolic Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

All Sirtuin Isoforms

All Caspase Isoforms

All GLUT Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

4'-Bromo-resveratrol Related Classifications

HY-124113 Related Classifications