AL-34662

Cat. No.: HY-125641 Purity: 99.19%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

AL-34662 is a selective 5-HT2A receptoragonist (IC₅₀: 0.77 nM and 1.5 nM for rat and human 5-HT2 receptor). AL-34662 is also a weak α-1D adrenergic agonist activity (EC₅₀:0.4 μM). AL-34662 is an ocular hypotensive agent.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

AL-34662 화학구조

CAS No. : 210580-75-9

사이즈	재고	수량
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

Other Forms of AL-34662:

AL-34662 formate 견적 받기

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Adrenergic Receptor Isoform Specific Products:

View All Isoforms

α adrenergic receptor β adrenergic receptor

View All 5-HT Receptor Isoform Specific Products:

View All Isoforms

5-HT Receptor 5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

5-HT_2A Receptor

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	1460 nM Compound: 9	Agonistic activity at cloned human 5HT1A receptor expressed in CHO cells by inhibition of forskolin-induced cAMP production Agonistic activity at cloned human 5HT1A receptor expressed in CHO cells by inhibition of forskolin-induced cAMP production	[PMID: 16392816]
HT-29	EC₅₀	2600 nM Compound: 9	Activity at adrenergic alpha2A receptor expressed in human clonic adenocarcinoma HT29 cell by tissue contraction assay Activity at adrenergic alpha2A receptor expressed in human clonic adenocarcinoma HT29 cell by tissue contraction assay	[PMID: 16392816]
HT-29	EC₅₀	> 10000 nM Compound: 9	Activity at adrenergic alpha-2A receptor expressed in human clonic adenocarcinoma HT29 cell by adenylyl cyclase assay Activity at adrenergic alpha-2A receptor expressed in human clonic adenocarcinoma HT29 cell by adenylyl cyclase assay	[PMID: 16392816]

분자량

191.23

화학식

C₁₀H₁₃N₃O

CAS No.

210580-75-9

Appearance

Solid

Color

White to off-white

SMILES

OC1=CC2=C(C=C1)C=NN2C[C@@H](N)C

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 62.5 mg/mL (326.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.2293 mL	26.1465 mL	52.2930 mL
5 mM	1.0459 mL	5.2293 mL	10.4586 mL
10 mM	0.5229 mL	2.6147 mL	5.2293 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.19%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (247 KB) HNMR (239 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Sharif NA, et al. AL-34662: a potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist. J Ocul Pharmacol Ther. 2007 Feb;23(1):1-13. [Content Brief]

[2]. Asano T, et al. Ameliorative effect of chlorpromazine hydrochloride on visceral hypersensitivity in rats: possible involvement of 5-HT2A receptor. Br J Pharmacol. 2017 Oct;174(19):3370-3381. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.2293 mL	26.1465 mL	52.2931 mL	130.7326 mL
	5 mM	1.0459 mL	5.2293 mL	10.4586 mL	26.1465 mL
	10 mM	0.5229 mL	2.6147 mL	5.2293 mL	13.0733 mL
	15 mM	0.3486 mL	1.7431 mL	3.4862 mL	8.7155 mL
	20 mM	0.2615 mL	1.3073 mL	2.6147 mL	6.5366 mL
	25 mM	0.2092 mL	1.0459 mL	2.0917 mL	5.2293 mL
	30 mM	0.1743 mL	0.8716 mL	1.7431 mL	4.3578 mL
	40 mM	0.1307 mL	0.6537 mL	1.3073 mL	3.2683 mL
	50 mM	0.1046 mL	0.5229 mL	1.0459 mL	2.6147 mL
	60 mM	0.0872 mL	0.4358 mL	0.8716 mL	2.1789 mL
	80 mM	0.0654 mL	0.3268 mL	0.6537 mL	1.6342 mL
	100 mM	0.0523 mL	0.2615 mL	0.5229 mL	1.3073 mL

AL-34662 Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AL-34662210580-75-9AL34662AL 34662Adrenergic Receptor5-HT ReceptorBeta ReceptorSerotonin Receptor5-hydroxytryptamine Receptorocular hypotensiveIOP5-HT2 Receptor AgonistInhibitorinhibitorinhibit

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