2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. CBiPES

CBiPES is a potent mGlu2 positive allosteric modulator with an EC50 value of 92.8 nM. CBiPES attenuates stress-induced hyperthermia and Phencyclidine-induced hyperlocomotor activity. CBiPES can be used for research of neurological diseases, such as Parkinson's disease (PD).

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CBiPES

CBiPES 構造式

CAS 番号 : 353235-01-5

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 220 在庫あり
Solution
10 mM * 1 mL in DMSO USD 220 在庫あり
Solid
5 mg $200 在庫あり
10 mg $330 在庫あり
25 mg $650 在庫あり
50 mg $1050 在庫あり
100 mg $1680 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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CBiPES 関連抗体

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製品説明

CBiPES is a potent mGlu2 positive allosteric modulator with an EC50 value of 92.8 nM. CBiPES attenuates stress-induced hyperthermia and Phencyclidine-induced hyperlocomotor activity. CBiPES can be used for research of neurological diseases, such as Parkinson's disease (PD)[1][2].

IC50 & Target

EC50: 92.8 nM (mGlu2 receptor)[1]
Cellular Effect
Cell Line Type Value Description References
Caco-2 CC50
13.4 μM
Compound: CBIPES
Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay
Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay
10.21203/rs.3.rs-23951/v1
Caco-2 IC50
17.05 μM
Compound: CBIPES
Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging
Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging
10.21203/rs.3.rs-23951/v1
体内実験

CBiPES (100 mg/kg; i.p.; once) attenuates a stress-induced hyperthermia and PCP-induced hyperlocomotor activity[1].
CBiPES (0.1-10 mg/kg) reduces global dyskinesia and diminishes global psychosis-like behaviours (PLBs) in the MPTP (HY-15608)-lesioned marmoset[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice were given a subcutaneous injection of PCP (7.5 mg/kg)[1]
Dosage: 100 mg/kg
Administration: i.p.; once
Result: Attenuated a stress-induced hyperthermia and PCP-induced hyperlocomotor activity.
分子量

377.46

分子式

C21H19N3O2S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

CCS(N(C1=CC(C2=CC=C(C#N)C=C2)=CC=C1)CC3=CN=CC=C3)(=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (264.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6493 mL 13.2464 mL 26.4929 mL
5 mM 0.5299 mL 2.6493 mL 5.2986 mL
10 mM 0.2649 mL 1.3246 mL 2.6493 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6493 mL 13.2464 mL 26.4929 mL 66.2322 mL
5 mM 0.5299 mL 2.6493 mL 5.2986 mL 13.2464 mL
10 mM 0.2649 mL 1.3246 mL 2.6493 mL 6.6232 mL
15 mM 0.1766 mL 0.8831 mL 1.7662 mL 4.4155 mL
20 mM 0.1325 mL 0.6623 mL 1.3246 mL 3.3116 mL
25 mM 0.1060 mL 0.5299 mL 1.0597 mL 2.6493 mL
30 mM 0.0883 mL 0.4415 mL 0.8831 mL 2.2077 mL
40 mM 0.0662 mL 0.3312 mL 0.6623 mL 1.6558 mL
50 mM 0.0530 mL 0.2649 mL 0.5299 mL 1.3246 mL
60 mM 0.0442 mL 0.2208 mL 0.4415 mL 1.1039 mL
80 mM 0.0331 mL 0.1656 mL 0.3312 mL 0.8279 mL
100 mM 0.0265 mL 0.1325 mL 0.2649 mL 0.6623 mL
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CBiPES Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CBiPES353235-01-5mGluRMetabotropic glutamate receptorspsychiatrichyperthermiahyperlocomotorstressParkinson’sInhibitorinhibitorinhibit

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製品名:
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製品番号:
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