2. GPCR/G Protein Immunology/Inflammation PROTAC
  3. CCR Ligands for Target Protein for PROTAC
  4. CCR7 Ligand 1

CCR7 Ligand 1  (Synonyms: CCR7-Cmp2105)

製品番号: HY-133073 純度: 99.19%
COA 取扱説明書 Technical Support

CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM.

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CCR7 Ligand 1

CCR7 Ligand 1 構造式

CAS 番号 : 681514-83-0

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 623 在庫あり
Solution
10 mM * 1 mL in DMSO USD 623 在庫あり
Solid
5 mg $595 在庫あり
10 mg $950 在庫あり
50 mg $2950 在庫あり
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Based on 3 publication(s) in Google Scholar

CCR7 Ligand 1 関連抗体

Top Publications Citing Use of Products

CCR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

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製品説明

CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM[1].

IC50 & Target[1]

Human CCR7

3 nM (Kd)

体外実験

CCR7 Ligand 1 (CCR7-Cmp2105) binds to a pocket at the intracellular part of CCR7 between the ends of TM1, TM2, TM3, and TM6 and the loop between TM7 and H8[1].
? CCR7 Ligand 1 allosterically inhibits binding of the native chemokine CCL19 ligand in scintillation proximity assays (bottom) with an IC50 of 35 nM[1].
? CCR7 Ligand 1 (20, 40, 60, 80, 100 μM) has dose-dependent thermo-stabilizing effect on CCR7[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CCR7 Ligand 1 関連抗体
分子量

475.56

分子式

C22H29N5O5S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C)C)C1=C(C)C=CC(NC(C(N[C@@H](C2=CC=C(C)O2)C(C)(C)C)=N3)=NS3(=O)=O)=C1O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (210.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1028 mL 10.5139 mL 21.0278 mL
5 mM 0.4206 mL 2.1028 mL 4.2056 mL
10 mM 0.2103 mL 1.0514 mL 2.1028 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

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体積 （終了）

V2

In Vivo Dissolution Calculator
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純度とドキュメンテーション

純度: 99.19%

COA (257 KB) LCMS (106 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1028 mL 10.5139 mL 21.0278 mL 52.5696 mL
5 mM 0.4206 mL 2.1028 mL 4.2056 mL 10.5139 mL
10 mM 0.2103 mL 1.0514 mL 2.1028 mL 5.2570 mL
15 mM 0.1402 mL 0.7009 mL 1.4019 mL 3.5046 mL
20 mM 0.1051 mL 0.5257 mL 1.0514 mL 2.6285 mL
25 mM 0.0841 mL 0.4206 mL 0.8411 mL 2.1028 mL
30 mM 0.0701 mL 0.3505 mL 0.7009 mL 1.7523 mL
40 mM 0.0526 mL 0.2628 mL 0.5257 mL 1.3142 mL
50 mM 0.0421 mL 0.2103 mL 0.4206 mL 1.0514 mL
60 mM 0.0350 mL 0.1752 mL 0.3505 mL 0.8762 mL
80 mM 0.0263 mL 0.1314 mL 0.2628 mL 0.6571 mL
100 mM 0.0210 mL 0.1051 mL 0.2103 mL 0.5257 mL
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CCR7 Ligand 1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCR7 Ligand 1681514-83-0CCR7-Cmp2105CCRLigands for Target Protein for PROTACCC chemokine receptorTarget Protein-binding MoietyallostericLigandCCchemokinereceptor7thiadiazole-dioxideliganCCL19Inhibitorinhibitorinhibit

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製品名:
CCR7 Ligand 1
製品番号:
HY-133073
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