2. MAPK/ERK Pathway NF-κB Immunology/Inflammation Apoptosis
  3. JNK NF-κB Interleukin Related TNF Receptor
  4. Ceramide 3

Ceramide 3  (Synonyms: N-Stearoyl phytosphingosine)

製品番号: HY-141582 純度: 98.0%
COA 取扱説明書 Technical Support

Ceramide 3 (N-Stearoyl phytosphingosine) is an orally active major component of intercellular lipids in the stratum corneum of the skin, and belongs to the ceramide family. Ceramide 3 inhibits c-jun and NF-κB activation induced by Histamine (HY-B1204), and suppresses the expression of IL-4 and TNF-α. Ceramide 3 inhibits scratching behavior and vascular permeability in mice, and exhibits antihistamine effects in guinea pig ileum. Ceramide 3 improves skin barrier function, reduces transepidermal water loss, erythema and the number of circulating epidermal cells, and accelerates barrier repair of irritated or dysfunctional skin.

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Ceramide 3

Ceramide 3 構造式

CAS 番号 : 34354-88-6

容量 価格（税別） 在庫状況 数量
1 mg $156 在庫あり
5 mg $389 在庫あり
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Other Forms of Ceramide 3:

Ceramide 3 関連抗体

Top Publications Citing Use of Products

JNK アイソフォーム固有の製品をすべて表示:

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JNK1 JNK2 JNK3 JNK

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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製品説明

Ceramide 3 (N-Stearoyl phytosphingosine) is an orally active major component of intercellular lipids in the stratum corneum of the skin, and belongs to the ceramide family. Ceramide 3 inhibits c-jun and NF-κB activation induced by Histamine (HY-B1204), and suppresses the expression of IL-4 and TNF-α. Ceramide 3 inhibits scratching behavior and vascular permeability in mice, and exhibits antihistamine effects in guinea pig ileum. Ceramide 3 improves skin barrier function, reduces transepidermal water loss, erythema and the number of circulating epidermal cells, and accelerates barrier repair of irritated or dysfunctional skin[1][2][3].

体内実験

Ceramide 3 (20-50 mg/kg; p.o.; single administration) dose-dependently inhibits histamine-induced pruritus and skin inflammation in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice (male, 5 weeks old, 20-22 g)[1]
Dosage: 20 mg/kg; 50 mg/kg
Administration: p.o.; single dose 1 hour prior to histamine challenge
Result: Reduced histamine-induced scratching behavior frequency (statistically significant vs.
histamine-treated group) at 20 mg/kg.
Inhibited histamine-induced IL-4 protein expression (statistically significant vs.
histamine-treated group) at 20 mg/kg.
Inhibited histamine-induced TNF-α protein expression (statistically significant vs.
histamine-treated group) at 20 mg/kg.
Reduced histamine-induced vascular permeability (statistically significant vs.
histamine-treated group) at 20 mg/kg.
Reduced histamine-induced skin inflammation (epidermal hyperplasia and inflammatory cell infiltration) at 20 mg/kg.
Reduced histamine-induced scratching behavior frequency by 67% at 50 mg/kg.
Inhibited histamine-induced IL-4 protein expression by 75% at 50 mg/kg.
Inhibited histamine-induced TNF-α protein expression by 88% at 50 mg/kg.
Reduced histamine-induced vascular permeability by 51% at 50 mg/kg.
Reduced histamine-induced skin inflammation (epidermal hyperplasia and inflammatory cell infiltration) at 50 mg/kg.
Inhibited histamine-induced activation of transcription factors NF-κB (phospho-p65) and c-jun (phospho-c-jun) at both 20 mg/kg and 50 mg/kg.
分子量

583.97

分子式

C36H73NO4
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(CCCCCCCCCCCCCCCCC)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

Methanol : 1 mg/mL (1.71 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7124 mL 8.5621 mL 17.1242 mL
5 mM --- --- ---
10 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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純度とドキュメンテーション

純度: 98.0%

COA (238 KB) HNMR (117 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Methanol 1 mM 1.7124 mL 8.5621 mL 17.1242 mL 42.8104 mL
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Ceramide 3 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ceramide 334354-88-6N-Stearoyl phytosphingosineCeramide3Ceramide-3JNKNF-κBInterleukin RelatedTNF Receptorc-Jun N-terminal kinaseNuclear factor-κBNuclear factor-kappaBILTumor Necrosis Factor ReceptorTNFRc-junskin barrier dysfunctionsodium lauryl sulfate-irritated skinguinea pig ileumTNF-αIL-4pruritusmicehistamineInhibitorinhibitorinhibit

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