2. Cytoskeleton
  3. Integrin
  4. Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA

Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA  (Synonyms: Cyclo(RGDfC) TFA)

Cat. No.: HY-P2300A Pureté: 98.69%
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Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC) TFA, a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA can be used in the research of tumors.

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Synthèse de peptides personnalisée

Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA

Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA Chemical Structure

Size Prix Stock Quantité
5 mg En stock
10 mg En stock
25 mg En stock
50 mg   Obtenir un devis  
100 mg   Obtenir un devis  

* Veuillez sélectionner la quantité avant d'ajouter des articles.

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Based on 2 publication(s) in Google Scholar

Other Forms of Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA:

Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA Related Antibodies

Top Publications Citing Use of Products

2 Publications Citing Use of MCE Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA

Voir tous les produits spécifiques à Isoform Integrin:

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

  • Activité biologique

  • Pureté et documentation

  • Références

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Description

Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC) TFA, a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA can be used in the research of tumors[1].

IC50 & Target[1]

αvβ3

 

In Vitro

Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA (0.5 mM; 24 h) down-regulates the transcription factors Oct 4, Sox 2 and Nanog of mESCs[1].
Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA (0.5 mM) inhibits integrin gene expression mESC-col I (type I collagen) constructs[1].
Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA (0.5 mM)-treated mESC leads to the formation of aggregates and detachment from the surface[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA Related Antibodies
In Vivo

Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA (0.5 mM, 24 h)-treated mESCs in the presence/absence of Leukemia inhibitory factor (LIF) (injected in both thighs) generated teratomas in severe combined immunodeficiency (SCID) mice, which indicates that the process of mESC tumor formation in vivo is dependent on integrin interaction[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Masse moléculaire

692.66

Formule

C26H35F3N8O9S
Appearance

Solid

Color

White to off-white

Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvant et solubilité
In Vitro: 

H2O : 5 mg/mL (7.22 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4437 mL 7.2185 mL 14.4371 mL
5 mM 0.2887 mL 1.4437 mL 2.8874 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureté et documentation
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.4437 mL 7.2185 mL 14.4371 mL 36.0927 mL
5 mM 0.2887 mL 1.4437 mL 2.8874 mL 7.2185 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclo(Arg-Gly-Asp-D-Phe-Cys)Cyclo(RGDfC)IntegrinInhibitorinhibitorinhibit

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