2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Disodium succinate

Disodium succinate  (Synonyms: コハク酸 二ナトリウム塩)

製品番号: HY-W015410 純度: 99.86%
COA 取扱説明書 Technical Support

Disodium succinate is an anti-anxiety agent with oral activity. Disodium succinate is the salt form of Succinic acid. Disodium succinate is an intermediate product of the tricarboxylic acid cycle. Disodium succinate is an important platform chemical. Disodium succinate can be used as surfactant, additive, ion chelating agent, flavoring agent and other applications in chemical, pharmaceutical and food fields.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 150-90-3

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in Water USD 27 在庫あり
Solid
100 mg $25 在庫あり
500 mg $40 在庫あり
1 g $50 在庫あり
5 g $80 在庫あり
10 g $95 在庫あり
25 g $133 在庫あり
50 g $160 在庫あり
100 g $190 在庫あり
> 100 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 10 publication(s) in Google Scholar

Other Forms of Disodium succinate:

Disodium succinate 関連抗体

Top Publications Citing Use of Products

    Disodium succinate purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2024 Dec;14(12):5267-5285.

    After lowering the concentration of Disodium succinate from 2.5% to 2% in water for 2 weeks, the body weight of the WT mice rebounded, whereas that of the IKO mice remained the same. Changes in body weight after the administration of sodium succinate to WT and IKO mice (fed with HFD for 24 week).

    Disodium succinate purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2024 Dec;14(12):5267-5285.

    Oxygen consumption rate and energy expenditure (heat production) of HFD-fed WT and IKO mice after 4 weeks of Disodium succinate administration (2.5%), as measured by CLAMS.

    Disodium succinate purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2024 Dec;14(12):5267-5285.

    Oral glucose tolerance tests (OGTTs) after 4 weeks of 2.5% Disodium succinate administration to HFD-fed (24-week-old) WT and IKO mice.

    Disodium succinate purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9.  [Abstract]

    Relative mRNA expression of IFN-b and cGAS in LoVo cells treated with succinic acid (0.5 mM;24 h) or F. nucleatum supernatant

    Disodium succinate purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9.  [Abstract]

    Representative immunoblotting of cGAS expression in HT29 and LoVo cells treated with succinic acid (0.5 mM; 24 h).

    Disodium succinate purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9.  [Abstract]

    Relative mRNA expression of CCL5 and CXCL10 in LoVo cells treated with succinic acid (0.5 mM; 24 h) or F. nucleatum supernatant.

    Disodium succinate purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9.  [Abstract]

    Relative expression of candidate transcriptional regulation elements in LoVo cells treated with succinic acid (0.5 mM; 24 h).

    Disodium succinate purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9.  [Abstract]

    Relative cGAS mRNA expression in LoVo cells transfected with EZH2 siRNA, then treated with succinic acid (0.5 mM; 24 h).

    Disodium succinate purchased from MedChemExpress. Usage Cited in: Research Square Print. December 9th, 2022.

    Disodium succinate (40 mM; 48 h) in ovaries were stripped from 21-day-old female KM mice elevated the global Ksuc level of mouse ovary cultured in vitro.

    Disodium succinate purchased from MedChemExpress. Usage Cited in: Research Square Print. December 9th, 2022.

    Disodium succinate (40 mM; 48 h) in ovaries were stripped from 21-day-old female KM mice showed the GCs in the ovaries of the succinate administration group were more sparsely arranged around the follicles compared to the control group.

    Disodium succinate purchased from MedChemExpress. Usage Cited in: Research Square Print. December 9th, 2022.

    Disodium succinate (40 mM; 48 h) in ovaries of 21-day-old female KM mice showed an increased staining in ovarian cells in the succinate group as compared with the control group.

    Disodium succinate purchased from MedChemExpress. Usage Cited in: Research Square Print. December 9th, 2022.

    Disodium succinate (40 mM; 48 h) in ovaries of 21-day-old female KM mice verified that B-cell lymphoma-2 (Bcl-2) significantly decreased and Cleaved-caspase 3 significantly increased in succinate-treated ovaries, whereas BCL2-associated X (Bax) and proliferating cell nuclear antigen (PCNA) did not change significantly in mRNA levels.

    Disodium succinate purchased from MedChemExpress. Usage Cited in: Research Square Print. December 9th, 2022.

    Disodium succinate (40 mM; 48 h) in ovaries of 21-day-old female KM mice verified that B-cell lymphoma-2 (Bcl-2) significantly decreased and Cleaved-caspase 3 significantly increased in succinate-treated ovaries, whereas BCL2-associated X (Bax) and proliferating cell nuclear antigen (PCNA) did not change significantly in protein levels.

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Disodium succinate is an anti-anxiety agent with oral activity. Disodium succinate is the salt form of Succinic acid. Disodium succinate is an intermediate product of the tricarboxylic acid cycle. Disodium succinate is an important platform chemical. Disodium succinate can be used as surfactant, additive, ion chelating agent, flavoring agent and other applications in chemical, pharmaceutical and food fields[1][2][3][4][5].

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    体内実験

    Succinic acid (3-6 mg/kg; p.o.; Single dose) has anti-anxiety effects in mice[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Elevated plus-maze test mice model[3]
    Dosage: 3 mg/kg, 6 mg/kg
    Administration: Oral gavage (p.o.); Single dose
    Result: At doses of 3.0 and 6.0 mg/kg significantly increased the percentage of mice that entered the open arm and the percentage of time that the open arm stayed.
    Animal Model: Food intake mice model [3]
    Dosage: 3 mg/kg, 6 mg/kg, 12 mg/kg
    Administration: Intraperitoneal injection (i.p.); Single dose
    Result: Significantly increased the mice's food intake within 5 minutes after administration.
    Animal Model: Stress-induced hyperthermia test mice model[3]
    Dosage: 1.5 mg/kg, 3 mg/kg, 6 mg/kg
    Administration: Oral gavage (p.o.); Single dose
    Result: Inhibited stress-induced hyperthermia at a dose of 1.5 mg/kg.
    分子量

    162.05

    分子式

    C4H4Na2O4
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(O[Na])CCC(O[Na])=O
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    Store at room temperature, keep dry and cool

    *In solvent : -80°C, 6 months; -20°C, 1 month (Store at room temperature, keep dry and cool)
    溶剤 & 溶解度
    体外: 

    H2O : ≥ 100 mg/mL (617.09 mM)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 6.1709 mL 30.8547 mL 61.7093 mL
    5 mM 1.2342 mL 6.1709 mL 12.3419 mL
    10 mM 0.6171 mL 3.0855 mL 6.1709 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (617.09 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.86%

    COA (245 KB) HNMR (220 KB) RP-HPLC (212 KB) MS (68 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 6.1709 mL 30.8547 mL 61.7093 mL 154.2734 mL
    5 mM 1.2342 mL 6.1709 mL 12.3419 mL 30.8547 mL
    10 mM 0.6171 mL 3.0855 mL 6.1709 mL 15.4273 mL
    15 mM 0.4114 mL 2.0570 mL 4.1140 mL 10.2849 mL
    20 mM 0.3085 mL 1.5427 mL 3.0855 mL 7.7137 mL
    25 mM 0.2468 mL 1.2342 mL 2.4684 mL 6.1709 mL
    30 mM 0.2057 mL 1.0285 mL 2.0570 mL 5.1424 mL
    40 mM 0.1543 mL 0.7714 mL 1.5427 mL 3.8568 mL
    50 mM 0.1234 mL 0.6171 mL 1.2342 mL 3.0855 mL
    60 mM 0.1028 mL 0.5142 mL 1.0285 mL 2.5712 mL
    80 mM 0.0771 mL 0.3857 mL 0.7714 mL 1.9284 mL
    100 mM 0.0617 mL 0.3085 mL 0.6171 mL 1.5427 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Disodium succinate Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Disodium150-90-3Endogenous MetaboliteChelating agentSurfactantPlatform chemicalFlavoring agentAdditiveAnaerobicFermentationPrecursorAnxiolyticOrally activeInhibitorinhibitorinhibit

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