Disodium succinate hexahydrate
Based on 4 publication(s) in Google Scholar
Disodium succinate hexahydrate (Wormwood acid disodium hexahydrate) is an anti-anxiety agent with oral activity. Disodium succinate hexahydrate is an intermediate product of the tricarboxylic acid cycle. Disodium succinate hexahydrate is an important platform chemical. Disodium succinate hexahydrate can be used as surfactant, additive, ion chelating agent, flavoring agent and other applications in chemical, pharmaceutical and food fields.
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- Pureza : 99.5%
- No. CAS: 6106-21-4
- Fòrmula: C4H16Na2O10
- Peso molecular:270.14
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
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Publications Citing Use of MedChemExpress (MCE) Disodium succinate hexahydrate
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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Histological Imaging/Staining
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Actividad biológica
Descripciòn
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Elevated plus-maze test mice model[3]
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Dosage:3 mg/kg, 6 mg/kg
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Administration:Oral gavage; Single dose
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Result:At doses of 3.0 and 6.0 mg/kg significantly increased the percentage of mice that entered the open arm and the percentage of time that the open arm stayed.
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Animal Model:Food intake mice model[3]
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Dosage:3 mg/kg, 6 mg/kg, 12 mg/kg
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Administration:Intraperitoneal injection (i.p.); Single dose
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Result:Significantly increased the mice's food intake within 5 minutes after administration.
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Animal Model:Stress-induced hyperthermia test mice model[3]
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Dosage:1.5 mg/kg, 3 mg/kg, 6 mg/kg
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Administration:Oral gavage; Single dose
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Result:Inhibited stress-induced hyperthermia at a dose of 1.5 mg/kg.
Chemical Information
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No. CAS 6106-21-4
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Appearance Solid
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Peso molecular 270.14
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Fòrmula C4H16Na2O10
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Color White to off-white
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SMILES
O=C(O[Na])CCC(O[Na])=O.O.[6]
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Synonyms
Wormwood acid disodium hexahydrate
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (4)
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Journal Impact Factor
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Most Recent
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Acta Pharm Sin B
2024 Dec;14(12):5267-5285. PMID: 39807334
Disodium succinate hexahydrate purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2024 Dec;14(12):5267-5285. [Abstract]
After lowering the concentration of Disodium succinate from 2.5% to 2% in water for 2 weeks, the body weight of the WT mice rebounded, whereas that of the IKO mice remained the same. Changes in body weight after the administration of sodium succinate to WT and IKO mice (fed with HFD for 24 week).
Disodium succinate hexahydrate purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2024 Dec;14(12):5267-5285. [Abstract]
Oxygen consumption rate and energy expenditure (heat production) of HFD-fed WT and IKO mice after 4 weeks of Disodium succinate administration (2.5%), as measured by CLAMS.
Disodium succinate hexahydrate purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2024 Dec;14(12):5267-5285. [Abstract]
Oral glucose tolerance tests (OGTTs) after 4 weeks of 2.5% Disodium succinate administration to HFD-fed (24-week-old) WT and IKO mice.
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Stem Cell Res Ther
From inflammation to healing: the crucial role of GPR91 activation and SDH inhibition in chronic diabetic wound recovery. [Abstract]2025 Jul 23;16(1):399. PMID: 40702577 -
J Proteomics
Global proteomic analysis reveals lysine succinylation is involved in the pathogenesis of hypertrophic scar. [Abstract]2024 Apr 30:298:105155. PMID: 38460743 -
Disodium succinate hexahydrate purchased from MedChemExpress. Usage Cited in: Research Square Print. December 9th, 2022.
Disodium succinate (40 mM; 48 h) in ovaries were stripped from 21-day-old female KM mice elevated the global Ksuc level of mouse ovary cultured in vitro.
Disodium succinate hexahydrate purchased from MedChemExpress. Usage Cited in: Research Square Print. December 9th, 2022.
Disodium succinate (40 mM; 48 h) in ovaries were stripped from 21-day-old female KM mice showed the GCs in the ovaries of the succinate administration group were more sparsely arranged around the follicles compared to the control group.
Disodium succinate hexahydrate purchased from MedChemExpress. Usage Cited in: Research Square Print. December 9th, 2022.
Disodium succinate (40 mM; 48 h) in ovaries of 21-day-old female KM mice showed an increased staining in ovarian cells in the succinate group as compared with the control group.
Disodium succinate hexahydrate purchased from MedChemExpress. Usage Cited in: Research Square Print. December 9th, 2022.
Disodium succinate (40 mM; 48 h) in ovaries of 21-day-old female KM mice verified that B-cell lymphoma-2 (Bcl-2) significantly decreased and Cleaved-caspase 3 significantly increased in succinate-treated ovaries, whereas BCL2-associated X (Bax) and proliferating cell nuclear antigen (PCNA) did not change significantly in mRNA levels.
Disodium succinate hexahydrate purchased from MedChemExpress. Usage Cited in: Research Square Print. December 9th, 2022.
Disodium succinate (40 mM; 48 h) in ovaries of 21-day-old female KM mice verified that B-cell lymphoma-2 (Bcl-2) significantly decreased and Cleaved-caspase 3 significantly increased in succinate-treated ovaries, whereas BCL2-associated X (Bax) and proliferating cell nuclear antigen (PCNA) did not change significantly in protein levels.
Solvente y solubilidad
In Vitro:
H2O : 100 mg/mL (370.18 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
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- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Zhang YJ, et al. Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology (RSM). J Zhejiang Univ Sci B. 2012 Feb;13(2):103-10. [Content Brief]
[2]. Johns A T. The production of propionic acid by decarboxylation of succinic acid in a bacterial fermentation. The Biochemical journal, 1948, 42(1): ii. [Content Brief]
[3]. Chen SW, Xin Q, Kong WX, Min L, Li JF. Anxiolytic-like effect of succinic acid in mice. Life Sci. 2003 Nov 7;73(25):3257-64. doi: 10.1016/j.lfs.2003.06.017. PMID: 14561530. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.7018 mL | 18.5089 mL | 37.0178 mL | 92.5446 mL |
| 5 mM | 0.7404 mL | 3.7018 mL | 7.4036 mL | 18.5089 mL | |
| 10 mM | 0.3702 mL | 1.8509 mL | 3.7018 mL | 9.2545 mL | |
| 15 mM | 0.2468 mL | 1.2339 mL | 2.4679 mL | 6.1696 mL | |
| 20 mM | 0.1851 mL | 0.9254 mL | 1.8509 mL | 4.6272 mL | |
| 25 mM | 0.1481 mL | 0.7404 mL | 1.4807 mL | 3.7018 mL | |
| 30 mM | 0.1234 mL | 0.6170 mL | 1.2339 mL | 3.0848 mL | |
| 40 mM | 0.0925 mL | 0.4627 mL | 0.9254 mL | 2.3136 mL | |
| 50 mM | 0.0740 mL | 0.3702 mL | 0.7404 mL | 1.8509 mL | |
| 60 mM | 0.0617 mL | 0.3085 mL | 0.6170 mL | 1.5424 mL | |
| 80 mM | 0.0463 mL | 0.2314 mL | 0.4627 mL | 1.1568 mL | |
| 100 mM | 0.0370 mL | 0.1851 mL | 0.3702 mL | 0.9254 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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