Disodium succinate

Name: Disodium succinate
Brand: MedChemExpress
SKU: HY-W015410
Rating: 5.0 (10 reviews)

Cat. No.: HY-W015410 Purity: 99.86%: Data Sheet
COA

SDS
Handling Instructions
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Disodium succinate is an anti-anxiety agent with oral activity. Disodium succinate is the salt form of Succinic acid. Disodium succinate is an intermediate product of the tricarboxylic acid cycle. Disodium succinate is an important platform chemical. Disodium succinate can be used as surfactant, additive, ion chelating agent, flavoring agent and other applications in chemical, pharmaceutical and food fields.

For research use only. We do not sell to patients.

CAS No. : 150-90-3

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	In-stock	Estimated Time of Arrival: December 31
100 g	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 10 publication(s) in Google Scholar

Other Forms of Disodium succinate:

10 Publications Citing Use of MCE Disodium succinate

RT-PCR

In Vivo Efficacy Study

Histological Imaging/Staining

Cell Imaging/Staining

: Disodium succinate purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2024 Dec;14(12):5267-5285.; After lowering the concentration of Disodium succinate from 2.5% to 2% in water for 2 weeks, the body weight of the WT mice rebounded, whereas that of the IKO mice remained the same. Changes in body weight after the administration of sodium succinate to WT and IKO mice (fed with HFD for 24 week).

: Disodium succinate purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2024 Dec;14(12):5267-5285.; Oxygen consumption rate and energy expenditure (heat production) of HFD-fed WT and IKO mice after 4 weeks of Disodium succinate administration (2.5%), as measured by CLAMS.

: Disodium succinate purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2024 Dec;14(12):5267-5285.; Oral glucose tolerance tests (OGTTs) after 4 weeks of 2.5% Disodium succinate administration to HFD-fed (24-week-old) WT and IKO mice.

: Disodium succinate purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]; Relative mRNA expression of IFN-b and cGAS in LoVo cells treated with succinic acid (0.5 mM;24 h) or F. nucleatum supernatant

: Disodium succinate purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]; Representative immunoblotting of cGAS expression in HT29 and LoVo cells treated with succinic acid (0.5 mM; 24 h).

: Disodium succinate purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]; Relative mRNA expression of CCL5 and CXCL10 in LoVo cells treated with succinic acid (0.5 mM; 24 h) or F. nucleatum supernatant.

: Disodium succinate purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]; Relative expression of candidate transcriptional regulation elements in LoVo cells treated with succinic acid (0.5 mM; 24 h).

: Disodium succinate purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]; Relative cGAS mRNA expression in LoVo cells transfected with EZH2 siRNA, then treated with succinic acid (0.5 mM; 24 h).

: Disodium succinate purchased from MedChemExpress. Usage Cited in: Research Square Print. December 9th, 2022.; Disodium succinate (40 mM; 48 h) in ovaries were stripped from 21-day-old female KM mice elevated the global Ksuc level of mouse ovary cultured in vitro.

: Disodium succinate purchased from MedChemExpress. Usage Cited in: Research Square Print. December 9th, 2022.; Disodium succinate (40 mM; 48 h) in ovaries were stripped from 21-day-old female KM mice showed the GCs in the ovaries of the succinate administration group were more sparsely arranged around the follicles compared to the control group.

: Disodium succinate purchased from MedChemExpress. Usage Cited in: Research Square Print. December 9th, 2022.; Disodium succinate (40 mM; 48 h) in ovaries of 21-day-old female KM mice showed an increased staining in ovarian cells in the succinate group as compared with the control group.

: Disodium succinate purchased from MedChemExpress. Usage Cited in: Research Square Print. December 9th, 2022.; Disodium succinate (40 mM; 48 h) in ovaries of 21-day-old female KM mice verified that B-cell lymphoma-2 (Bcl-2) significantly decreased and Cleaved-caspase 3 significantly increased in succinate-treated ovaries, whereas BCL2-associated X (Bax) and proliferating cell nuclear antigen (PCNA) did not change significantly in mRNA levels.

: Disodium succinate purchased from MedChemExpress. Usage Cited in: Research Square Print. December 9th, 2022.; Disodium succinate (40 mM; 48 h) in ovaries of 21-day-old female KM mice verified that B-cell lymphoma-2 (Bcl-2) significantly decreased and Cleaved-caspase 3 significantly increased in succinate-treated ovaries, whereas BCL2-associated X (Bax) and proliferating cell nuclear antigen (PCNA) did not change significantly in protein levels.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

In Vivo

Succinic acid (3-6 mg/kg; p.o.; Single dose) has anti-anxiety effects in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Elevated plus-maze test mice model^[3]
Dosage:	3 mg/kg, 6 mg/kg
Administration:	Oral gavage (p.o.); Single dose
Result:	At doses of 3.0 and 6.0 mg/kg significantly increased the percentage of mice that entered the open arm and the percentage of time that the open arm stayed.

Animal Model:	Food intake mice model ^[3]
Dosage:	3 mg/kg, 6 mg/kg, 12 mg/kg
Administration:	Intraperitoneal injection (i.p.); Single dose
Result:	Significantly increased the mice's food intake within 5 minutes after administration.

Animal Model:	Stress-induced hyperthermia test mice model^[3]
Dosage:	1.5 mg/kg, 3 mg/kg, 6 mg/kg
Administration:	Oral gavage (p.o.); Single dose
Result:	Inhibited stress-induced hyperthermia at a dose of 1.5 mg/kg.

Molecular Weight

162.05

Formula

C₄H₄Na₂O₄

CAS No.

150-90-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])CCC(O[Na])=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (617.09 mM)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.1709 mL	30.8547 mL	61.7093 mL
5 mM	1.2342 mL	6.1709 mL	12.3419 mL
10 mM	0.6171 mL	3.0855 mL	6.1709 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (617.09 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.86%

Select Batch:

Data Sheet (276 KB) SDS (480 KB)

COA (245 KB) HNMR (220 KB) RP-HPLC (212 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Zhang YJ, et al. Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology (RSM). J Zhejiang Univ Sci B. 2012 Feb;13(2):103-10. [Content Brief]

[2]. Johns A T. The production of propionic acid by decarboxylation of succinic acid in a bacterial fermentation[J]. The Biochemical journal, 1948, 42(1): ii. [Content Brief]

[3]. Chen SW, Xin Q, Kong WX, Min L, Li JF. Anxiolytic-like effect of succinic acid in mice. Life Sci. 2003 Nov 7;73(25):3257-64. doi: 10.1016/j.lfs.2003.06.017. PMID: 14561530. [Content Brief]

[4]. Xu J, et al. Microbial succinic acid, its polymer poly (butylene succinate), and applications[J]. Plastics from bacteria: Natural functions and applications, 2010: 347-388.

[5]. Bechthold I, et al. Succinic acid: a new platform chemical for biobased polymers from renewable resources[J]. Chemical Engineering & Technology: Industrial Chemistry‐Plant Equipment‐Process Engineering‐Biotechnology, 2008, 31(5): 647-654.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	6.1709 mL	30.8547 mL	61.7093 mL	154.2734 mL
	5 mM	1.2342 mL	6.1709 mL	12.3419 mL	30.8547 mL
	10 mM	0.6171 mL	3.0855 mL	6.1709 mL	15.4273 mL
	15 mM	0.4114 mL	2.0570 mL	4.1140 mL	10.2849 mL
	20 mM	0.3085 mL	1.5427 mL	3.0855 mL	7.7137 mL
	25 mM	0.2468 mL	1.2342 mL	2.4684 mL	6.1709 mL
	30 mM	0.2057 mL	1.0285 mL	2.0570 mL	5.1424 mL
	40 mM	0.1543 mL	0.7714 mL	1.5427 mL	3.8568 mL
	50 mM	0.1234 mL	0.6171 mL	1.2342 mL	3.0855 mL
	60 mM	0.1028 mL	0.5142 mL	1.0285 mL	2.5712 mL
	80 mM	0.0771 mL	0.3857 mL	0.7714 mL	1.9284 mL
	100 mM	0.0617 mL	0.3085 mL	0.6171 mL	1.5427 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.