2. Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein
  3. Phospholipase Dopamine Receptor
  4. Halopemide

Halopemide is a potent phospholipase D (PLD) inhibitor, with IC50s of 220 and 310 nM for human PLD1 and PLD2, respectively. Halopemid is a dopamine receptors antagonist, and acts a psychotropic agent.

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No. CAS : 59831-65-1

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ready for reconstitution
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Based on 1 publication(s) in Google Scholar

Other Forms of Halopemide:

Halopemide Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Halopemide

Flow Cytometry

    Halopemide purchased from MedChemExpress. Usage Cited in: Nat Microbiol. 2025 Nov;10(11):2949-2965.  [Abstract]

    Naive CD4+ T cells were stimulated with anti-CD3 and anti-CD28 antibodies in the presence of IL-2 and TGFβ for 3 days and treated with DMSO or treated with Linoleic acid (100 μM) for 48 h. Linoleic acid promotes Ca2+-dependent CTLA-4 surface trafficking.

    Ver todos los productos específicos de isoformas Phospholipase:

    Ver todas las isoformas
    Phospholipase A PLD Phospholipase C

    Ver todos los productos específicos de isoformas Dopamine Receptor:

    Ver todas las isoformas
    Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

    • Actividad biológica

    • Pureza y Documentación

    • Referencias

    • Revisión del cliente

    Descripciòn

    Halopemide is a potent phospholipase D (PLD) inhibitor, with IC50s of 220 and 310 nM for human PLD1 and PLD2, respectively. Halopemid is a dopamine receptors antagonist, and acts a psychotropic agent[1][2].

    IC50 & Target[1][2]

    D1 Receptor

     

    D2 Receptor

     

    PLD1

    220 nM (IC50)

    PLD2

    310 nM (IC50)

    Cellular Effect
    Cell Line Type Value Description References
    Calu-1 IC50
    21 nM
    Compound: 8
    Inhibition of PLD1 in human Calu-1 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis
    Inhibition of PLD1 in human Calu-1 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis
    		[PMID: 19136975]
    Calu-1 IC50
    21 nM
    Compound: 1
    Inhibition of human PLD1 in Calu1 cells
    Inhibition of human PLD1 in Calu1 cells
    		[PMID: 19268584]
    HEK293 IC50
    300 nM
    Compound: 1
    Inhibition of GFP-labelled human PLD2 HEK293 cells
    Inhibition of GFP-labelled human PLD2 HEK293 cells
    		[PMID: 19268584]
    HEK293 IC50
    6500 nM
    Compound: 8
    Inhibition of GFP-tagged human PLD2 expressed in human HEK293 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis
    Inhibition of GFP-tagged human PLD2 expressed in human HEK293 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis
    		[PMID: 19136975]
    In Vitro

    Halopemide (1-2 μM; 21 day) affects calcification in transdifferentiated MOVAS cells[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Halopemide Related Antibodies
    In Vivo

    Halopemide (10 mg/kg; p.o.) induces dyskinesias in the majority of monkeys tested[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Peso molecular

    416.88

    Fòrmula

    C21H22ClFN4O2
    No. CAS
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    O=C(C1=CC=C(C=C1)F)NCCN2CCC(CC2)N3C4=CC=C(C=C4NC3=O)Cl
    Envío

    Room temperature in continental US; may vary elsewhere.
    Almacenamiento
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvente y solubilidad
    In Vitro: 

    DMSO : 41.67 mg/mL (99.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3988 mL 11.9939 mL 23.9877 mL
    5 mM 0.4798 mL 2.3988 mL 4.7975 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Calculadora de molaridad

    • Calculadora de dilución

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Pureza y Documentación

    Purity: 99.65%

    SDS (392 KB)

    COA (251 KB) LCMS (98 KB)

    Instrucciones de manejo (2659 KB)
    Referencias

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.3988 mL 11.9939 mL 23.9877 mL 59.9693 mL
    5 mM 0.4798 mL 2.3988 mL 4.7975 mL 11.9939 mL
    10 mM 0.2399 mL 1.1994 mL 2.3988 mL 5.9969 mL
    15 mM 0.1599 mL 0.7996 mL 1.5992 mL 3.9980 mL
    20 mM 0.1199 mL 0.5997 mL 1.1994 mL 2.9985 mL
    25 mM 0.0960 mL 0.4798 mL 0.9595 mL 2.3988 mL
    30 mM 0.0800 mL 0.3998 mL 0.7996 mL 1.9990 mL
    40 mM 0.0600 mL 0.2998 mL 0.5997 mL 1.4992 mL
    50 mM 0.0480 mL 0.2399 mL 0.4798 mL 1.1994 mL
    60 mM 0.0400 mL 0.1999 mL 0.3998 mL 0.9995 mL
    80 mM 0.0300 mL 0.1499 mL 0.2998 mL 0.7496 mL
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    Halopemide Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Halopemide59831-65-1PhospholipaseDopamine ReceptorpsychotropiccalcificationdyskinesiascancerMOVAScellsInhibitorinhibitorinhibit

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    Nombre del producto:
    Halopemide
    Cat. No.:
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