2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC-IN-32

HDAC-IN-32 is a potent HDAC inhibitor with IC50s of 5.2, 11, and 28 nM for HDAC1, HDAC2 and HDAC6, respectively. HDAC-IN-32 possesses potent antiproliferation activities against tumor cells. HDAC-IN-32 shows potent antitumor efficacy in vivo That trigger antitumor immunity.

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HDAC-IN-32

HDAC-IN-32 Estructura química

No. CAS : 2766688-17-7

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HDAC-IN-32 Related Antibodies

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Ver todos los productos específicos de isoformas HDAC:

Ver todas las isoformas
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Descripciòn

HDAC-IN-32 is a potent HDAC inhibitor with IC50s of 5.2, 11, and 28 nM for HDAC1, HDAC2 and HDAC6, respectively. HDAC-IN-32 possesses potent antiproliferation activities against tumor cells. HDAC-IN-32 shows potent antitumor efficacy in vivo That trigger antitumor immunity[1].

Cellular Effect
Cell Line Type Value Description References
B16-F10 IC50
4.8 μM
Compound: 9k
Antiproliferative activity against mouse B16-F10 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against mouse B16-F10 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 35152694]
HEL IC50
0.02 μM
Compound: 9k
Antiproliferative activity against HEL cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against HEL cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 35152694]
HepG2 IC50
3.9 μM
Compound: 9k
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 35152694]
K562 IC50
0.29 μM
Compound: 9k
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 35152694]
KG-1 IC50
0.19 μM
Compound: 9k
Antiproliferative activity against human KG-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human KG-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 35152694]
PC-3 IC50
2.7 μM
Compound: 9k
Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 35152694]
In Vitro

HDAC-IN-32 (compound 9k) induces upregulation of Ac-HH3 and Ac-tubulin in tumor cells and induces apoptosis by cleavage of caspase-3. HDAC-IN-32 induces downregulation of SSRP1 and SPT16 and leads to chromatin damage. HDAC-IN-32 possesses better antimigration activities than SAHA and could reduce the expression level of MMP-2, which plays critical roles in tumor migration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-32 Related Antibodies
Peso molecular

353.41

Fòrmula

C20H23N3O3
No. CAS
SMILES

O=C(NO)CCCCCCOC1=CC=CC(C2=NC3=CC=CC=C3N2)=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

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Referencias
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HDAC-IN-32 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-322766688-17-7HDACHistone deacetylasesantitumorimmunitychromatin damageantiproliferationtumor cellsantimigrationInhibitorinhibitorinhibit

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Nombre del producto:
HDAC-IN-32
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HY-145687
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