Heptelidic acid (Synonyms: Koningic acid)

Name: Heptelidic acid
Brand: MedChemExpress
SKU: HY-120838
Rating: 4.5 (1 reviews)

Cat. No.: HY-120838 Purity: 97.5%: Data Sheet
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Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic. Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases. Koningic acid (KA) is a specific GAPDH inhibitor with an IC₅₀of 90 μM.

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Heptelidic acid 화학구조

CAS No. : 57710-57-3

사이즈	재고	수량
500 μg	해외재고보유	Estimated Time of Arrival: December 31
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	견적 받기
10 mg	견적 받기

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고객리뷰

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Heptelidic acid

•MedComm (2020). 2025 Jan 28;6(2):e70077. [Abstract]

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic^[1]. Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases^[2]. Koningic acid (KA) is a specific GAPDH inhibitor with an IC₅₀of 90 μM^[3].

IC₅₀ & Target^[2]

Caspase-3

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	1.26 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human A375 cells assessed as inhibition of cell proliferation incubated for 24 hrs by conventional ATP quantification method Antiproliferative activity against human A375 cells assessed as inhibition of cell proliferation incubated for 24 hrs by conventional ATP quantification method	[PMID: 25937235]
A-375	IC₅₀	1.26 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human A375 cells assessed as inhibition of cell proliferation incubated for 24 hrs by conventional ATP quantification method Antiproliferative activity against human A375 cells assessed as inhibition of cell proliferation incubated for 24 hrs by conventional ATP quantification method	[PMID: 25937235]
A-375	IC₅₀	1.34 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human A375 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human A375 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
A-375	IC₅₀	1.34 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human A375 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human A375 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
A549	IC₅₀	0.458 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
A549	IC₅₀	0.458 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
A-375	IC₅₀	1.26 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human A375 cells assessed as inhibition of cell proliferation incubated for 24 hrs by conventional ATP quantification method Antiproliferative activity against human A375 cells assessed as inhibition of cell proliferation incubated for 24 hrs by conventional ATP quantification method	[PMID: 25937235]
A549	IC₅₀	0.99 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
A549	IC₅₀	0.99 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
A-375	IC₅₀	1.34 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human A375 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human A375 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
BXPC-3	IC₅₀	0.76 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human BxPC3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human BxPC3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
BXPC-3	IC₅₀	0.76 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human BxPC3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human BxPC3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
COLO 205	IC₅₀	0.63 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human COLO205 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human COLO205 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
COLO 205	IC₅₀	0.63 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human COLO205 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human COLO205 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
DU-145	IC₅₀	0.89 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human DU145 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human DU145 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
DU-145	IC₅₀	0.89 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human DU145 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human DU145 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
A549	IC₅₀	0.458 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
HCT-116	IC₅₀	0.21 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human HCT116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human HCT116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
HCT-116	IC₅₀	0.21 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human HCT116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human HCT116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
A549	IC₅₀	0.99 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
HCT-116	IC₅₀	0.93 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human HCT116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human HCT116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
HCT-116	IC₅₀	0.93 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human HCT116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human HCT116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
BXPC-3	IC₅₀	0.76 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human BxPC3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human BxPC3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
HL-60	IC₅₀	0.76 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human HL60 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human HL60 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
HL-60	IC₅₀	0.76 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human HL60 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human HL60 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
HOP-62	IC₅₀	0.51 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human HOP62 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human HOP62 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
HOP-62	IC₅₀	0.51 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human HOP62 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human HOP62 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
COLO 205	IC₅₀	0.63 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human COLO205 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human COLO205 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
KG-1	IC₅₀	0.4 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human KG1 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human KG1 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
KG-1	IC₅₀	0.4 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human KG1 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human KG1 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
DU-145	IC₅₀	0.89 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human DU145 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human DU145 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
KM12	IC₅₀	0.41 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human KM12 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human KM12 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
HCT-116	IC₅₀	0.21 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human HCT116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human HCT116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
KM12	IC₅₀	0.41 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human KM12 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human KM12 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
MDA-MB-231	IC₅₀	0.45 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
MDA-MB-231	IC₅₀	0.45 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
HCT-116	IC₅₀	0.93 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human HCT116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human HCT116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
NAMALVA	IC₅₀	0.302 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human NAMALWA cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human NAMALWA cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
NAMALVA	IC₅₀	0.302 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human NAMALWA cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human NAMALWA cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
NCI-H460	IC₅₀	0.49 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
HL-60	IC₅₀	0.76 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human HL60 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human HL60 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
NCI-H460	IC₅₀	0.49 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
OVCAR-3	IC₅₀	0.69 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human OVCAR3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human OVCAR3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
OVCAR-3	IC₅₀	0.69 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human OVCAR3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human OVCAR3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
HOP-62	IC₅₀	0.51 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human HOP62 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human HOP62 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
SK-OV-3	IC₅₀	0.34 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human SKOV3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human SKOV3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
SK-OV-3	IC₅₀	0.34 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human SKOV3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human SKOV3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
KG-1	IC₅₀	0.4 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human KG1 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human KG1 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
T47D	IC₅₀	0.21 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human T47D cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human T47D cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
KM12	IC₅₀	0.41 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human KM12 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human KM12 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
T47D	IC₅₀	0.21 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human T47D cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human T47D cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
MDA-MB-231	IC₅₀	0.45 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
TK-10	IC₅₀	0.66 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human TK10 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human TK10 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
TK-10	IC₅₀	0.66 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human TK10 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human TK10 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
NAMALVA	IC₅₀	0.302 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human NAMALWA cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human NAMALWA cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
WM 266-4	IC₅₀	0.509 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human WM266.4 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human WM266.4 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
WM 266-4	IC₅₀	0.509 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human WM266.4 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human WM266.4 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
NCI-H460	IC₅₀	0.49 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
OVCAR-3	IC₅₀	0.69 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human OVCAR3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human OVCAR3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
SK-OV-3	IC₅₀	0.34 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human SKOV3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human SKOV3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
T47D	IC₅₀	0.21 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human T47D cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human T47D cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
TK-10	IC₅₀	0.66 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human TK10 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human TK10 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]
WM 266-4	IC₅₀	0.509 3 Compound: 1, KA, heptelidic acid	Antiproliferative activity against human WM266.4 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method Antiproliferative activity against human WM266.4 cells assessed as inhibition of cell proliferation incubated for 72 hrs by conventional ATP quantification method	[PMID: 25937235]

In Vitro

Heptelidic acid is a sesquiterpene antibiotic, found in the culture filtrate of three different strains of fungi isolated from soil samples. Heptelidic acid produces organisms, fermentation, isolation and characterization^[1].
Heptelidic acid inhibits Etoposide-induced apoptosis in human leukemia U937 cells^[2].Heptelidic acid inhibits caspase- 3 induction in U937 cells with an IC₅₀ value of 40 μM after 8 h of Etoposide treatment^[2].
Heptelidic acid (Koningic acid; KA), a natural product obtained from the Trichoderma fungus, can directly bind to the active site of human GAPDH. The expression of T. koningii KAr-GAPDH successfully rescued cell viability in human cells treated with Heptelidic acid. HEK293T cells expressing T. koningii KAr-GAPDH exhibited complete cell viability after treatment with 0-200 μM Heptelidic acid with the IC₅₀=5 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:	HEK293T cells expressing KAr-GAPDH or EV (top left)
Concentration:	0.1, 1, 10, 100, 1000 μM
Incubation Time:	24 hours
Result:	IC₅₀=5 μM.

In Vivo

Heptelidic acid (Koningic acid; KA) is bioavailable and induces dynamic changes to glycolysis in vivo^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-week old female Foxn1^nu mice bearing BT-474 tumor^[3]
Dosage:	1, 2.5, 5, and 10 mg/kg
Administration:	Daily intraperitoneal (IP) injections, 24 hours
Result:	1 mg/kg was determined to be the maximum tolerated dose (MTD) based upon behavioral monitoring and adverse events at higher doses (hemolysis, hematuria, and anemia).

분자량

280.32

화학식

C₁₅H₂₀O₅

CAS No.

57710-57-3

Appearance

Solid

Color

Colorless to off-white

SMILES

O=C(C1=C[C@@]2([H])[C@]([C@@]3(OC3)CC[C@@H]2C(C)C)([H])C(OC1)=O)O

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : ≥ 30 mg/mL (107.02 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5674 mL	17.8368 mL	35.6735 mL
5 mM	0.7135 mL	3.5674 mL	7.1347 mL
10 mM	0.3567 mL	1.7837 mL	3.5674 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 97.5%

Select Batch:

Data Sheet (285 KB) SDS (394 KB)

COA (261 KB)

Handling Instructions (2659 KB)

References

[1]. Y Itoh, et al. A new sesquiterpene antibiotic, heptelidic acid producing organisms, fermentation, isolation and characterization. J Antibiot (Tokyo). 1980 May;33(5):468-73. [Content Brief]

[2]. Jin Hee Kim, et al. Heptelidic acid, a sesquiterpene lactone, inhibits Etoposide-induced apoptosis in human leukemia U937 cells. J Microbiol Biotechnol. 2009 Aug;19(8):787-91. [Content Brief]

[3]. Maria V Liberti, et al. A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Cell Metab. 2017 Oct 3;26(4):648-659.e8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5674 mL	17.8368 mL	35.6735 mL	89.1838 mL
	5 mM	0.7135 mL	3.5674 mL	7.1347 mL	17.8368 mL
	10 mM	0.3567 mL	1.7837 mL	3.5674 mL	8.9184 mL
	15 mM	0.2378 mL	1.1891 mL	2.3782 mL	5.9456 mL
	20 mM	0.1784 mL	0.8918 mL	1.7837 mL	4.4592 mL
	25 mM	0.1427 mL	0.7135 mL	1.4269 mL	3.5674 mL
	30 mM	0.1189 mL	0.5946 mL	1.1891 mL	2.9728 mL
	40 mM	0.0892 mL	0.4459 mL	0.8918 mL	2.2296 mL
	50 mM	0.0713 mL	0.3567 mL	0.7135 mL	1.7837 mL
	60 mM	0.0595 mL	0.2973 mL	0.5946 mL	1.4864 mL
	80 mM	0.0446 mL	0.2230 mL	0.4459 mL	1.1148 mL
	100 mM	0.0357 mL	0.1784 mL	0.3567 mL	0.8918 mL

Heptelidic acid Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Heptelidic acid57710-57-3Koningic acidCaspasesesquiterpeneantibioticEtoposideapoptosiscaspasesGAPDHInhibitorinhibitorinhibit

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Heptelidic acid (Synonyms: Koningic acid)

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Heptelidic acid Related Antibodies

1 Publications Citing Use of MCE Heptelidic acid

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Heptelidic acid Related Antibodies

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Heptelidic acid Related Classifications

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