57710-57-3
57710-57-3
Chemical Structure
Heptelidic acid
Synonym(s): Koningic acid
- CAS No.: 57710-57-3
- Formula:C15H20O5
- Molecular Weight:280.32
IUPAC Name: (5aS,6R,9S,9aS)-6-isopropyl-1-oxo-1,5a,6,7,8,9a-hexahydro-3H-spiro[benzo[c]oxepine-9,2'-oxirane]-4-carboxylic acid
InChIKey: JESMSCGUTIEROV-RTWAVKEYSA-N
SMILES: O=C(C1=C[C@@]2([H])[C@]([C@@]3(OC3)CC[C@@H]2C(C)C)([H])C(OC1)=O)O
Biological Activity: Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic[1]. Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases[2]. Koningic acid (KA) is a specific GAPDH inhibitor with an IC50of 90 μM[3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Heptelidic acid | 97.5% | Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic. Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases. Koningic acid (KA) is a specific GAPDH inhibitor with an IC50of 90 μM. | ||||||||||||||||||||
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References
- [1]. Y Itoh, et al. A new sesquiterpene antibiotic, heptelidic acid producing organisms, fermentation, isolation and characterization. J Antibiot (Tokyo). 1980 May;33(5):468-73. [Content Brief]
- [2]. Jin Hee Kim, et al. Heptelidic acid, a sesquiterpene lactone, inhibits Etoposide-induced apoptosis in human leukemia U937 cells. J Microbiol Biotechnol. 2009 Aug;19(8):787-91. [Content Brief]
- [3]. Maria V Liberti, et al. A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Cell Metab. 2017 Oct 3;26(4):648-659.e8. [Content Brief]
