57710-57-3
57710-57-3
Chemical Structure
Heptelidic acid
Synonym(s): Koningic acid
- CAS No.: 57710-57-3
- Formula:C15H20O5
- Molecular Weight:280.32
IUPAC Name: (5aS,6R,9S,9aS)-6-isopropyl-1-oxo-1,5a,6,7,8,9a-hexahydro-3H-spiro[benzo[c]oxepine-9,2'-oxirane]-4-carboxylic acid
InChIKey: JESMSCGUTIEROV-RTWAVKEYSA-N
SMILES: O=C(C1=C[C@@]2([H])[C@]([C@@]3(OC3)CC[C@@H]2C(C)C)([H])C(OC1)=O)O
Biological Activity: Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic[1]. Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases[2]. Koningic acid (KA) is a specific GAPDH inhibitor with an IC50of 90 μM[3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Heptelidic acid | 97.5% | Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic. Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases. Koningic acid (KA) is a specific GAPDH inhibitor with an IC50of 90 μM. | ||||||||||||||||||||
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14-Acetoxy parthenolide | 14-Acetoxy parthenolide (compound 6a) is a parthenolide (PTL) derivative. 14-Acetoxy parthenolide exhibits potent anti-acute myeloid leukemia (AML) activity against HL-60 and KG1a cells, with IC50 values of 2.8 µM and 6.3 µM, respectively. 14-Acetoxy parthenolide can be used for AML research. | |||||||||||||||||||||
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Helenalin isobutyrate | Helenalin isobutyrate is an NF-κB (p65 subunit) inhibitor with anti-inflammatory activity. Helenalin isobutyrate irreversibly alkylates cysteine sulfhydryl groups in the p65 subunit to inhibit NF-κB complex DNA binding activity. | |||||||||||||||||||||
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Taraxinic acid | Taraxinic acid can be found in the roots of Taraxacum flavostylum and Taraxacum lucidum. It is a Tyrosinase inhibitor that dose-dependently inhibits Tyrosinase activity, showing approximately 54.5% inhibition at a concentration of 50 μg/mL. Taraxinic acid has an IC50 of 83.2 μM against melanoma cells A375 and HTB140, and an IC50 of 60.4 μM against melanoma cells WM793, with activity being both dose- and time-dependent. Taraxinic acid holds promise for research in the field of anticancer therapy. | |||||||||||||||||||||
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11β,13-Dihydrotaraxinic acid | 11β,13-Dihydrotaraxinic acid is a natural sesquiterpene. | |||||||||||||||||||||
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Dodovislactone A | Dodovislactone A is a natural diterpene. | |||||||||||||||||||||
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3-Acetoxy-4-cadinen-8-one | 3-Acetoxy-4-cadinen-8-one is a Sesquiterpenoids product that can be isolated from the herbs of Eupatorium adenophorum.. | |||||||||||||||||||||
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Vulgarin | Vulgarin is an orally active, naturally occurring eudesmane sesquiterpene with multiple biological activities including anti-inflammatory and antioxidant properties. Vulgarin targets and inhibits HMGB1, NF-κB and iNOS, while regulating key genes involved in hepatic gluconeogenesis; it also blocks inflammatory signaling pathways and inhibits the production and release of pro-inflammatory cytokines such as TNF-α and IL-1β. Vulgarin effectively alleviates pancreatic oxidative stress by reducing lipid peroxidation levels and restoring antioxidant enzyme activity. Vulgarin reverses abnormally elevated serum pancreatic enzyme levels, preserves the integrity of pancreatic acinar cells, and reduces pancreatic edema, hemorrhage and inflammatory infiltration. Vulgarin remodels the function of pancreatic endocrine cells, restores insulin content in β cells, and downregulates glucagon levels in α cells and somatostatin levels in δ cells. Vulgarin can be used in studies related to pancreatic injury and diabetes. | |||||||||||||||||||||
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Alpiniaterpene A | Alpiniaterpene A is a Sesquiterpenoids product that can be isolated from the rhizomes of Alpinia officinarum.. | |||||||||||||||||||||
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ArnicolideC | 99.0% | ArnicolideC is a sesquiterpene lactone isolated Centipeda minima. ArnicolideC exertes a cytotoxic effect on the panel of Nasopharyngeal carcinoma (NPC) cells, significantly inhibiting cell growth in a dose- and time- dependent manner. ArnicolideC also exhibits inhibitory effects on NPC proliferation. | ||||||||||||||||||||
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Arnicolide D | 99.69% | Arnicolide D is a sesquiterpene lactone that can be isolated from Centipeda minima. Arnicolide D is cytotoxic to tumor cells and can induce cell cycle arrest, apoptosis, and oncosis in tumor cells. Arnicolide D has anti-tumor activity. | ||||||||||||||||||||
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References
- [1]. Y Itoh, et al. A new sesquiterpene antibiotic, heptelidic acid producing organisms, fermentation, isolation and characterization. J Antibiot (Tokyo). 1980 May;33(5):468-73. [Content Brief]
- [2]. Jin Hee Kim, et al. Heptelidic acid, a sesquiterpene lactone, inhibits Etoposide-induced apoptosis in human leukemia U937 cells. J Microbiol Biotechnol. 2009 Aug;19(8):787-91. [Content Brief]
- [3]. Maria V Liberti, et al. A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Cell Metab. 2017 Oct 3;26(4):648-659.e8. [Content Brief]
