2. Anti-infection TGF-beta/Smad Epigenetics
  3. PKC HIV
  4. HIV-1 protease-IN-10

HIV-1 protease-IN-10 (Compound 2) has HIV-1 latency reversing activity (IC50: 0.22 μM). HIV-1 protease-IN-10 binds to the PKCδ C1b domain (IC50: 0.69 μM). HIV-1 protease-IN-10 has stability against esterase-mediated hydrolysis.

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HIV-1 protease-IN-10

HIV-1 protease-IN-10 Estructura química

No. CAS : 2982527-11-5

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HIV-1 protease-IN-10 Related Antibodies

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

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Descripciòn

HIV-1 protease-IN-10 (Compound 2) has HIV-1 latency reversing activity (IC50: 0.22 μM). HIV-1 protease-IN-10 binds to the PKCδ C1b domain (IC50: 0.69 μM). HIV-1 protease-IN-10 has stability against esterase-mediated hydrolysis[1].

Cellular Effect
Cell Line Type Value Description References
Jurkat CC50
>10 3
Compound: 2
Cytotoxicity against human Jurkat cells assessed as reduction in cell viability incubated for 24 hrs by Ghost dye 780 staining based flow cytometric analysis
Cytotoxicity against human Jurkat cells assessed as reduction in cell viability incubated for 24 hrs by Ghost dye 780 staining based flow cytometric analysis
[PMID: 37224601]
Jurkat CC50
> 10 3
Compound: 2
Cytotoxicity against human Jurkat cells assessed as reduction in cell viability incubated for 24 hrs by Ghost dye 780 staining based flow cytometric analysis
Cytotoxicity against human Jurkat cells assessed as reduction in cell viability incubated for 24 hrs by Ghost dye 780 staining based flow cytometric analysis
[PMID: 37224601]
Peso molecular

396.56

Fòrmula

C23H40O5
No. CAS
SMILES

O=C1OC(CO)(COC(C(CCCCCC)CCCCCC)=O)C/C1=C(C)/C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
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Referencias
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HIV-1 protease-IN-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-1 protease-IN-102982527-11-5PKCHIVProtein kinase CHuman immunodeficiency virusLRAslatency reversing agentsC1b domainlatencyantiviralinfectionInhibitorinhibitorinhibit

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Nombre del producto:
HIV-1 protease-IN-10
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HY-155599
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