2. Anti-infection
  3. Antibiotic Bacterial
  4. Isepamicin sulfate

Isepamicin sulfate  (Synonyms: Sch 21420 sulfate)

製品番号: HY-100589 純度: 98.0%
COA 取扱説明書 Technical Support

Isepamicin sulfate (Sch 21420 sulfate) is a broad-spectrum aminoglycoside antibiotic. Isepamicin sulfate has considerable antimicrobial activity against some Gram-negative non-fermenting bacteria that are highly resistant to antibiotics. Isepamicin sulfate inhibits writhing reactions induced by Acetic acid (HY-Y0319), regulates vascular blood flow and blood pressure, and inhibits spontaneous uterine movements. Isepamicin sulfate has antidiuretic and blood sugar-raising effects. Isepamicin sulfate can be used in seizure research.

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Isepamicin sulfate

Isepamicin sulfate 構造式

CAS 番号 : 67814-76-0

容量 価格（税別） 在庫状況 数量
5 mg $50 在庫あり
10 mg $70 在庫あり
25 mg $130 在庫あり
50 mg $210 在庫あり
100 mg $340 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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Other Forms of Isepamicin sulfate:

Isepamicin sulfate 関連抗体

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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製品説明

Isepamicin sulfate (Sch 21420 sulfate) is a broad-spectrum aminoglycoside antibiotic. Isepamicin sulfate has considerable antimicrobial activity against some Gram-negative non-fermenting bacteria that are highly resistant to antibiotics. Isepamicin sulfate inhibits writhing reactions induced by Acetic acid (HY-Y0319), regulates vascular blood flow and blood pressure, and inhibits spontaneous uterine movements. Isepamicin sulfate has antidiuretic and blood sugar-raising effects. Isepamicin sulfate can be used in seizure research[1][2].

IC50 & Target

Aminoglycoside

 

体外実験

Isepamicin sulfate (0.3-1 mg/mL) inhibits spontaneous beating of isolated atria, spontaneous movement of isolated ileum[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Isepamicin sulfate 関連抗体
体内実験

Isepamicin sulfate (12.5-50 mg/kg; i.v.) increases femoral artery blood flow, decreases blood pressure, increases respiratory rate, and increases carotid artery blood flow in anesthetized dogs[2].
Isepamicin sulfate (100 mg/kg; i.v.) causes an increase in heart rate in conscious rabbits, without significant changes in blood pressure or electrocardiogram[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子式

C22H43N5O12.xH2SO4
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=S(O)(O)=O.O[C@@H]1[C@H]([C@@H](C[C@H](N)[C@H]1O[C@@]([C@@H]([C@@H](O)[C@@H]2O)O)([H])O[C@@H]2CN)NC([C@@H](O)CN)=O)O[C@](OC[C@](C)(O)[C@@H]3NC)([H])[C@@H]3O.[x]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外: 

H2O : 125 mg/mL (Need ultrasonic)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL; Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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参考文献
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Isepamicin sulfate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isepamicin67814-76-0Sch 21420Sch21420Sch-21420AntibioticBacterialInhibitorinhibitorinhibit

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Isepamicin sulfate
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