2. MAPK/ERK Pathway Stem Cell/Wnt Neuronal Signaling Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Autophagy PI3K/Akt/mTOR
  3. JNK Wnt β-catenin Amyloid-β Reactive Oxygen Species (ROS) Beclin1 GSK-3 Beta-secretase
  4. JNK3/Wnt/β-catenin modulator-1

JNK3/Wnt/β-catenin modulator-1 is a brain-penetrant JNK3 inhibitor and Wnt/β-catenin activator. JNK3/Wnt/β-catenin modulator-1 decreases Aβ1-42 production and reduced ROS generation. JNK3/Wnt/β-catenin modulator-1 inhibits the activation of JNK and Puma, promotes Beclin-1 expression, reduces GSK-3β and BACE1 expression and activates Wnt/β-catenin signaling. JNK3/Wnt/β-catenin modulator-1 improves cognitive and memory performance, attenuates histopathological brain damage, preserves structure of hippocampal pyramidal cells and cerebral cortical neurons. JNK3/Wnt/β-catenin modulator-1 can be used for the research of Alzheimer's disease.

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JNK3/Wnt/β-catenin modulator-1

JNK3/Wnt/β-catenin modulator-1 Chemical Structure

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JNK3/Wnt/β-catenin modulator-1 Related Antibodies

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JNK1 JNK2 JNK3 JNK

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Wnt1 Wnt3 Wnt5 Wnt7 Wnt11

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GSK-3 GSK-3α GSK-3β

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BACE1 BACE2

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Description

JNK3/Wnt/β-catenin modulator-1 is a brain-penetrant JNK3 inhibitor and Wnt/β-catenin activator. JNK3/Wnt/β-catenin modulator-1 decreases Aβ1-42 production and reduced ROS generation. JNK3/Wnt/β-catenin modulator-1 inhibits the activation of JNK and Puma, promotes Beclin-1 expression, reduces GSK-3β and BACE1 expression and activates Wnt/β-catenin signaling. JNK3/Wnt/β-catenin modulator-1 improves cognitive and memory performance, attenuates histopathological brain damage, preserves structure of hippocampal pyramidal cells and cerebral cortical neurons. JNK3/Wnt/β-catenin modulator-1 can be used for the research of Alzheimer's disease[1].

IC50 & Target[1]

GSK-3β

 

BACE1

 

JNK3

 

In Vivo

JNK3/Wnt/β-catenin modulator-1 (compound 3a) (10 mg/kg; i.p.; daily; 45 days) improves cognitive function, reduces AD-related pathological markers, and modulates key signaling pathways in an AlCl3-induced AD rat model[1].
JNK3/Wnt/β-catenin modulator-1 (10 mg/kg; i.p.; daily; 45 days) has no significant effect on normal rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wister (male, 230-250 g, AlCl₃-induced AD model)[1]
Dosage: 10 mg/kg
Administration: i.p.; daily; 45 days
Result: Reduced brain amyloid beta 1-42 levels by 56.2%, JNK levels by 62.17%, Puma levels by 65.24% and ROS levels by 59.25% compared to the AlCl3-treated group.
Increased brain Beclin-1 levels by 877% compared to the AlCl3-treated group.
Upregulated mRNA expression of Wnt7a (175%), β-catenin (282%), LRP6 (330%), and FZD4 (411%) compared to the AlCl3-treated group.
Downregulated mRNA expression of GSK-3β (56%) and BACE1 (75%) compared to the AlCl3-treated group.
Improved spatial memory by reducing escape latency in Morris Water Maze, recognition memory by increasing discrimination index and ratio in Novel Object Recognition, and working memory by increasing spontaneous alternation percentage in Y-maze compared to the AlCl3-treated group.
Restored nearly normal histological structure of hippocampal pyramidal cells and cerebral cortical neurons with minimal pyknotic nuclei compared to the AlCl3-treated group.
Molecular Weight

380.42

Formula

C18H16N6O2S
SMILES

O=S(C1=CC=C(N2N=NC=C2C)C=C1)(C3=CC=C(N4N=NC=C4C)C=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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JNK3/Wnt/β-catenin modulator-1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNK3/Wnt/β-catenin modulator-1JNKWntβ-cateninAmyloid-βReactive Oxygen Species (ROS)Beclin1GSK-3Beta-secretasec-Jun N-terminal kinaseBeta cateninβ-amyloid peptideAβAbetaAtg6Glycogen synthase kinase-3Glycogen synthase kinase 3BACEβ-Secretasereactive oxygen speciesPumaGSK-3βc-Jun N-terminal kinase 3Wnt7aBeclin-1LRP6FZD4Wnt/β-catenin signalingInhibitorinhibitorinhibit

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