JNK3/Wnt/β-catenin modulator-1
JNK3/Wnt/β-catenin modulator-1 is a brain-penetrant JNK3 inhibitor and Wnt/β-catenin activator. JNK3/Wnt/β-catenin modulator-1 decreases Aβ1-42 production and reduced ROS generation. JNK3/Wnt/β-catenin modulator-1 inhibits the activation of JNK and Puma, promotes Beclin-1 expression, reduces GSK-3β and BACE1 expression and activates Wnt/β-catenin signaling. JNK3/Wnt/β-catenin modulator-1 improves cognitive and memory performance, attenuates histopathological brain damage, preserves structure of hippocampal pyramidal cells and cerebral cortical neurons. JNK3/Wnt/β-catenin modulator-1 can be used for the research of Alzheimer's disease.
For research use only. We do not sell to patients.
- Formula: C18H16N6O2S
- Molecular Weight:380.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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GSK-3β |
BACE1 |
JNK3 |
JNK3/Wnt/β-catenin modulator-1 (10 mg/kg; i.p.; daily; 45 days) has no significant effect on normal rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wister (male, 230-250 g, AlCl₃-induced AD model)[1]
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Dosage:10 mg/kg
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Administration:i.p.; daily; 45 days
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Result:Reduced brain amyloid beta 1-42 levels by 56.2%, JNK levels by 62.17%, Puma levels by 65.24% and ROS levels by 59.25% compared to the AlCl3-treated group.
Increased brain Beclin-1 levels by 877% compared to the AlCl3-treated group.
Upregulated mRNA expression of Wnt7a (175%), β-catenin (282%), LRP6 (330%), and FZD4 (411%) compared to the AlCl3-treated group.
Downregulated mRNA expression of GSK-3β (56%) and BACE1 (75%) compared to the AlCl3-treated group.
Improved spatial memory by reducing escape latency in Morris Water Maze, recognition memory by increasing discrimination index and ratio in Novel Object Recognition, and working memory by increasing spontaneous alternation percentage in Y-maze compared to the AlCl3-treated group.
Restored nearly normal histological structure of hippocampal pyramidal cells and cerebral cortical neurons with minimal pyknotic nuclei compared to the AlCl3-treated group.
Chemical Information
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Molecular Weight 380.42
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Formula C18H16N6O2S
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SMILES
O=S(C1=CC=C(N2N=NC=C2C)C=C1)(C3=CC=C(N4N=NC=C4C)C=C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JNK3/Wnt/β-catenin modulator-1 Related Classifications
HY-181160 Related Classifications
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