2. GPCR/G Protein MAPK/ERK Pathway Apoptosis
  3. Ras Apoptosis
  4. Zoldonrasib

Zoldonrasib  (Synonyms: RMC-9805; KRAS G12D inhibitor 18)

製品番号: HY-156819 純度: 99.52%
COA 取扱説明書 Technical Support

Zoldonrasib (RMC-9805) is a potent and orally active KRAS G12D inhibitor.Zoldonrasib induces apoptosis in KRAS G12D mutant cancer cells. Zoldonrasib has the potential for the research of KRAS G12D mutant cancer.

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CAS 番号 : 2922732-54-3

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 873 在庫あり
Solution
10 mM * 1 mL in DMSO USD 873 在庫あり
Solid
1 mg $160 在庫あり
5 mg $400 在庫あり
10 mg $680 在庫あり
25 mg $1125 在庫あり
50 mg $1660 在庫あり
100 mg $2320 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 5 publication(s) in Google Scholar

Zoldonrasib 関連抗体

Top Publications Citing Use of Products

    Zoldonrasib purchased from MedChemExpress. Usage Cited in: Nature. 2026 Feb;650(8102):748-758.  [Abstract]

    Liver metastatic burden in AKPT treated from 7 days post-transplantation and continued for 21 days. RMC9805 (100 mg/kg, oral, daily, 3 weeks) versus RMC6236 versus combined RMC9805–RMC6236 versus vehicle are shown.

    Zoldonrasib purchased from MedChemExpress. Usage Cited in: Mol Cell. 2026 Jan 8;86(1):60-77.e7.  [Abstract]

    Western blotting of AURKA, SRSF1, MYC, phosphorylated and total ERK1/2 (p-ERK and t-ERK, respectively), and VINC from SUIT2 parental cells and SUIT2 RMC-9805-resistant cells. Cells were either treated with DMSO, RMC-9805 (1 μM), or RMC-9805 (1 μM) + SC or ASO-A (65 nM) for 48 h.

    Zoldonrasib purchased from MedChemExpress. Usage Cited in: Mol Cell. 2026 Jan 8;86(1):60-77.e7.  [Abstract]

    Parental cells were sensitive to RMC-9805 (1 μM, 48 h), showing reduced extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation (p-ERK), drug-resistant cells, on the other hand, maintain mitogen-activated protein kinase (MAPK) signaling.

    Zoldonrasib purchased from MedChemExpress. Usage Cited in: Mol Cell. 2026 Jan 8;86(1):60-77.e7.  [Abstract]

    Parental cells were sensitive to RMC-9805 (1 μM, 48 h), resulting in decreased cell viability, while drug-resistant cells maintained cell viability.

    Ras アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    K-Ras H-Ras N-Ras Ras

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Zoldonrasib (RMC-9805) is a potent and orally active KRAS G12D inhibitor.Zoldonrasib induces apoptosis in KRAS G12D mutant cancer cells. Zoldonrasib has the potential for the research of KRAS G12D mutant cancer[1][2].

    IC50 & Target[1]

    KRAS(G12D)

     

    体外実験

    Zoldonrasib (RMC-9805) (100 nM; 48 h) inhibits the production of CXCL1, GM-CSF and decreases the production of CXCL10, CCL17 in eCT26 (KRASG12D/G12D) cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Zoldonrasib 関連抗体
    体内実験

    Zoldonrasib (RMC-9805) (100 mg/kg; po; once daily for 4-8 days) shows antitumor activity in KRAS G12D xenograft models[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Mice[2]
    Dosage: 100 mg/kg
    Administration: PO; once daily for 4-8 days
    Result: Decreased the level of myeloid cells, such as mMDSC, gMDSC, M2 TAMS, increased the level of cytotoxic T cells including CD3e+, CD4+, CD8+ T cells.
    臨床実験
    分子量

    1168.44

    分子式

    C63H88F3N11O7
    CAS 番号
    Appearance

    Solid

    Color

    White to yellow

    SMILES

    O=C([C@H]1NN(C([C@@H](NC([C@@H](N2C[C@]3(CN(C([C@@H]4N(C)[C@@H]4C5CC5)=O)CC3)CC2)C6CCCC6)=O)C[C@H]7CN8CCO7)=O)CCC1)OCC(C)(C)CC9=[C@@]([C@@]%10=C([C@@H](OC)C)N=CC(N%11CCN(C%12CC%12)CC%11)=C%10)N(CC(F)(F)F)C%13=C9C=C8C=C%13
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (85.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.8558 mL 4.2792 mL 8.5584 mL
    5 mM 0.1712 mL 0.8558 mL 1.7117 mL
    10 mM 0.0856 mL 0.4279 mL 0.8558 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

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    体積 （開始）

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    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (2.14 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (2.14 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.73%

    COA (255 KB) HNMR (359 KB) LCMS (96 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 0.8558 mL 4.2792 mL 8.5584 mL 21.3961 mL
    5 mM 0.1712 mL 0.8558 mL 1.7117 mL 4.2792 mL
    10 mM 0.0856 mL 0.4279 mL 0.8558 mL 2.1396 mL
    15 mM 0.0571 mL 0.2853 mL 0.5706 mL 1.4264 mL
    20 mM 0.0428 mL 0.2140 mL 0.4279 mL 1.0698 mL
    25 mM 0.0342 mL 0.1712 mL 0.3423 mL 0.8558 mL
    30 mM 0.0285 mL 0.1426 mL 0.2853 mL 0.7132 mL
    40 mM 0.0214 mL 0.1070 mL 0.2140 mL 0.5349 mL
    50 mM 0.0171 mL 0.0856 mL 0.1712 mL 0.4279 mL
    60 mM 0.0143 mL 0.0713 mL 0.1426 mL 0.3566 mL
    80 mM 0.0107 mL 0.0535 mL 0.1070 mL 0.2675 mL
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    Zoldonrasib Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Zoldonrasib2922732-54-3RMC-9805 KRAS G12D inhibitor 18RMC9805RMC 9805RasApoptosisapoptosisKRAS G12D mutantanticancerorally activeInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
    HY-156819
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