Maytansine (Synonyms: NSC 153858)

Name: Maytansine
Brand: MedChemExpress
SKU: HY-13674
Rating: 4.5 (0 reviews)

製品番号: HY-13674 純度: 99.81%: Data Sheet SDS COA 取扱説明書
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Maytansine is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations.

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Maytansine 構造式

CAS 番号 : 35846-53-8

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 114	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 114	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$75	在庫あり	Estimated Time of Arrival: December 31
10 mg	$95	在庫あり	Estimated Time of Arrival: December 31
25 mg	$220	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 0 publication(s) in Google Scholar

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•関連小分子:

•関連タンパク質:

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製品説明

Maytansine is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	0.74 nM Compound: Maytansine	Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38294341]
A-375	IC₅₀	0.037 nM Compound: 1	Cytotoxicity against human A375 cell line by clonogenic plating efficiency assay after 72 hrs Cytotoxicity against human A375 cell line by clonogenic plating efficiency assay after 72 hrs	[PMID: 16821799]
A-431	IC₅₀	0.04 nM Compound: 1	Cytotoxicity against human A431 cell line by clonogenic plating efficiency assay after 72 hrs Cytotoxicity against human A431 cell line by clonogenic plating efficiency assay after 72 hrs	[PMID: 16821799]
A549	IC₅₀	0.16 nM Compound: 1	Cytotoxicity against human A549 cell line by clonogenic plating efficiency assay after 72 hrs Cytotoxicity against human A549 cell line by clonogenic plating efficiency assay after 72 hrs	[PMID: 16821799]
A549	IC₅₀	0.59 nM Compound: Maytansine	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38294341]
HCT-15	IC₅₀	0.75 nM Compound: 1	Cytotoxicity against human HCT15 cell line by clonogenic plating efficiency assay after 72 hrs Cytotoxicity against human HCT15 cell line by clonogenic plating efficiency assay after 72 hrs	[PMID: 16821799]
HeLa	IC₅₀	0.33 nM Compound: Maytansine	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38294341]
HeLa	IC₅₀	1.1 nM Compound: Maytansine	Antiproliferative activity against human HeLa cells expressing tubulin betaIII assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells expressing tubulin betaIII assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38294341]
KB	ED₅₀	0.0000061 μg/mL Compound: 1	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 563462]
KB	ED₅₀	0.51 μg/mL Compound: Maytansine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 7130986]
KB	IC₅₀	0.034 nM Compound: 1	Cytotoxicity against human KB cell line by clonogenic plating efficiency assay after 72 hrs Cytotoxicity against human KB cell line by clonogenic plating efficiency assay after 72 hrs	[PMID: 16821799]
MCF7	IC₅₀	0.044 nM Compound: 1	Cytotoxicity against human MCF7 cell line by clonogenic plating efficiency assay after 72 hrs Cytotoxicity against human MCF7 cell line by clonogenic plating efficiency assay after 72 hrs	[PMID: 16821799]
OVCAR-3	IC₅₀	0.1 nM Compound: 1	Cytotoxicity against human Ovcar3 cell line by clonogenic plating efficiency assay after 72 hrs Cytotoxicity against human Ovcar3 cell line by clonogenic plating efficiency assay after 72 hrs	[PMID: 16821799]
SK-BR-3	IC₅₀	0.03 nM Compound: 1	Cytotoxicity against human SK-Br-3 cell line by clonogenic plating efficiency assay after 72 hrs Cytotoxicity against human SK-Br-3 cell line by clonogenic plating efficiency assay after 72 hrs	[PMID: 16821799]
SW-620	IC₅₀	>0.1 nM Compound: 1	Cytotoxicity against human SW620 cell line by clonogenic plating efficiency assay after 72 hrs Cytotoxicity against human SW620 cell line by clonogenic plating efficiency assay after 72 hrs	[PMID: 16821799]

体外実験

Maytansine, at 6x10^-8 M, irreversibly inhibits cell division in eggs of sea urchins and clams. Maytansine causes the disappearance of a mitotic apparatus or prevents one from forming if added at early stages. Maytansine inhibits in vitro polymerization of tubulin^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

692.20

分子式

C₃₄H₄₆ClN₃O₁₀

CAS 番号

35846-53-8

Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(C)=O)=O)=O)C)=C(C(OC)=C4)Cl)\C)OC)(NC(O3)=O)O)C)([H])O1

Structure Classification

Initial Source

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (144.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4447 mL	7.2233 mL	14.4467 mL
5 mM	0.2889 mL	1.4447 mL	2.8893 mL
10 mM	0.1445 mL	0.7223 mL	1.4447 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (3.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.81%

Select Batch:

データシート (281 KB) SDS (393 KB)

COA (262 KB) LCMS (94 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Lopus M, et al. Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules. Mol Cancer Ther. 2010;9(10):2689-2699. [Content Brief]

[2]. Remillard S, et al. Antimitotic activity of the potent tumor inhibitor maytansine. Science. 1975;189(4207):1002-1005. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4447 mL	7.2233 mL	14.4467 mL	36.1167 mL
	5 mM	0.2889 mL	1.4447 mL	2.8893 mL	7.2233 mL
	10 mM	0.1445 mL	0.7223 mL	1.4447 mL	3.6117 mL
	15 mM	0.0963 mL	0.4816 mL	0.9631 mL	2.4078 mL
	20 mM	0.0722 mL	0.3612 mL	0.7223 mL	1.8058 mL
	25 mM	0.0578 mL	0.2889 mL	0.5779 mL	1.4447 mL
	30 mM	0.0482 mL	0.2408 mL	0.4816 mL	1.2039 mL
	40 mM	0.0361 mL	0.1806 mL	0.3612 mL	0.9029 mL
	50 mM	0.0289 mL	0.1445 mL	0.2889 mL	0.7223 mL
	60 mM	0.0241 mL	0.1204 mL	0.2408 mL	0.6019 mL
	80 mM	0.0181 mL	0.0903 mL	0.1806 mL	0.4515 mL
	100 mM	0.0144 mL	0.0722 mL	0.1445 mL	0.3612 mL

Maytansine Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Maytansine35846-53-8NSC 153858NSC153858NSC-153858Microtubule/Tubulinpotentmicrotubule-targetedmitoticarresttumorsubnanomolarInhibitorinhibitorinhibit

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Maytansine (Synonyms: NSC 153858)

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Maytansine 関連抗体

おすすめ

•関連スクリーニングライブラリ:

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純度とドキュメンテーション

参考文献

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Maytansine 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Maytansine Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

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