MTX-216 

MTX-216 is a dual ATP-competitive inhibitor of PI3K and EGFR. MTX-216 cosuppresses Ki-67 and ribosomal S6 phosphorylation and induces apoptosis in NF1^LOF cells. MTX-216 suppresses the activity of SYK kinase, with an IC₅₀ of 281 nM. MTX-216 is used in the research of Melanoma^[1].

MTX-216 is highly effective in blocking NF1^LOF melanoma growth in vitro and in vivo^[1].
MTX-216 suppresses the expression of a group of genes that regulate the mitochondrial electron transport chain^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MTX-216 (50 mg/kg, once every other day, 11-20 days, Mice bearing xenografts of COLO792 cells and WM3918 cells) inhibits tumor growth^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

502.35

C₂₂H₁₄Cl₂FN₅O₂S

1952236-19-9

N#CC1=C(NC2=CC=C(C(Cl)=C2)F)C3=CC(C4=CC(NS(=O)(C)=O)=C(Cl)N=C4)=CC=C3N=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Cara Abecunas, et al. Loss of NF1 in Melanoma Confers Sensitivity to SYK Kinase Inhibition. Cancer Res. 2023 Jan 18;83(2):316-331.  [Content Brief]