1952236-19-9
1952236-19-9
Chemical Structure
MTX-216
- CAS. Nr.: 1952236-19-9
- Formula:C22H14Cl2FN5O2S
- Molecular Weight:502.35
InChIKey: WEVXFHBMHZDTAQ-UHFFFAOYSA-N
SMILES: N#CC1=C(NC2=CC=C(C(Cl)=C2)F)C3=CC(C4=CC(NS(=O)(C)=O)=C(Cl)N=C4)=CC=C3N=C1
Biological Activity: MTX-216 is a dual ATP-competitive inhibitor of PI3K and EGFR. MTX-216 cosuppresses Ki-67 and ribosomal S6 phosphorylation and induces apoptosis in NF1LOF cells. MTX-216 suppresses the activity of SYK kinase, with an IC50 of 281 nM. MTX-216 is used in the research of Melanoma[1].
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MTX-216 | MTX-216 is a dual ATP-competitive inhibitor of PI3K and EGFR. MTX-216 cosuppresses Ki-67 and ribosomal S6 phosphorylation and induces apoptosis in NF1LOF cells. MTX-216 suppresses the activity of SYK kinase, with an IC50 of 281 nM. MTX-216 is used in the research of Melanoma. | |||||||||||||||||||||
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References
Keywords
