2. Peptides
  3. Peptide and Derivatives
  4. Antimicrobial Peptides

Antimicrobial Peptides

Custom Peptide Synthesis

Antimicrobial peptides (AMPs) are a class of small peptides that play a pivotal role in host innate immunity, primarily exhibiting broad-spectrum activity against bacteria, fungi, and viruses, and in many cases also demonstrating anti-parasitic and anti-tumor effects.

Antimicrobial Peptides (655):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P1222
    LL-37, human 154947-66-7 99.82%
    LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human could help protect the cornea from infection and modulates wound healing.
    LL-37, human
  • HY-B0108
    Daptomycin 103060-53-3 99.90%
    Daptomycin is a lipopeptide antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.
    Daptomycin
  • HY-A0248
    Polymyxin B Sulfate 1405-20-5
    Polymyxin B Sulfate is an antibiotic. Polymyxin B Sulfate inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B Sulfate neutralizes the effect of endotoxin. Polymyxin B Sulfate induces bacterial death by increasing its permeability. Polymyxin B Sulfate is used in endotoxemia research.
    Polymyxin B Sulfate
  • HY-P0233
    Melittin 20449-79-0 99.78%
    Melittin is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not the increase activity of the high molecular weight PLA2.
    Melittin
  • HY-B0990
    Thiostrepton 1393-48-2 99.80%
    Thiostrepton is a thiazole antibiotic which selectively inhibits FOXM1. FOXM1 binds to YAP/TEAD complex. YAP/TEAD/FOXM1 complex binding at regulatory regions of genes governing cell cycle may impact cell proliferation.
    Thiostrepton
  • HY-P5731A
    Bac7(1-35) acetate 98.88%
    Bac7(1-35) acetate is a proline-rich antimicrobial peptide. Bac7(1-35) acetate efficiently binds to different regions of prokaryote ribosomes, leading to the inhibition of protein synthesis. Bac7(1-35) acetate demonstrates in vitro activity against P. aeruginosa strains.
    Bac7(1-35) acetate
  • HY-P10696A
    C16G2 TFA
    C16G2 TFA is a specific targeted antimicrobial peptide (STAMP) that targets the cariogenic oral pathogen Streptococcus mutans. C16G2 TFA specifically recognizes and disrupts the bacterial cell membrane, causing small molecule leakage and loss of membrane potential, leading to bacterial killing. C16G2 TFA exhibits higher selectivity and efficacy against Streptococcus mutans, unlike broad-spectrum antimicrobial peptides.
    C16G2 TFA
  • HY-P11825
    APH-IN-1
    APH-IN-1 is an Aminoglycoside phosphotransferase (APH) inhibitor with a Kd values of 63 nM against Escherichia coli APH(3′)-Ia. APH-IN-1 binds primarily to the ATP-binding pocket of APH in an ATP-competitive manner, with binding affinity enhanced by divalent metal ions (Mg2+ and Ca2+). APH-IN-1 can be used for the research of aminoglycoside-resistant bacterial infections.
    APH-IN-1
  • HY-106783
    Polymyxin B nonapeptide 86408-36-8 99.83%
    Polymyxin B nonapeptide is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes.
    Polymyxin B nonapeptide
  • HY-P1607
    Nisin 1414-45-5
    Nisin is a bacteriocin produced by a group of Gram-positive bacteria that belongs to Lactococcus and Streptococcus species. Nisin has antibacterial and anti-inflammatory activity.
    Nisin
  • HY-P0163
    Gramicidin 1405-97-6 99.5%
    Gramicidin is an antimicrobial peptide assembling as channels in membranes and increasing their permeability towards cations.
    Gramicidin
  • HY-P1222A
    LL-37, human TFA 99.96%
    LL-37, human TFA is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human TFA could help protect the cornea from infection and modulates wound healing.
    LL-37, human TFA
  • HY-P1975
    Aureobasidin A 127785-64-2 99.31%
    Aureobasidin A (Basifungin) is a cyclic peptide antibiotic with oral activity. Aureobasidin A is an inhibitor of inositol phosphorylated ceramide synthetase AUR1. Aureobasidin A has antifungal and antiparasitic activity.
    Aureobasidin A
  • HY-N6708
    Alamethicin 27061-78-5 99.67%
    Alamethicin is a linear 20-amino acid antibiotic, which can induce voltage-gated conductance in model and cell membranes. Alamethicin exhibits antimicrobial activity against Gram-positive bacteria, but not Gram-negative bacteria. Alamethicin can form an amphipathic α-helical structure in biological membranes.
    Alamethicin
  • HY-P1222B
    LL-37, human acetate 99.71%
    LL-37, human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human acetate could help protect the cornea from infection and modulates wound healing.
    LL-37, human acetate
  • HY-P5645
    LEAP-2 1683582-94-6
    LEAP-2 (Human liver expressed antimicrobial peptide-2) is a GHS-R1a antagonist, with an IC50 of 6.0 nM. LEAP-2 suppresses the orexigenic effect of ghrelin. LEAP-2 attenuates ghrelin-induced growth hormone (GH) release and reduces basal food intake. LEAP-2 exhibits antimicrobial activity against microbial model organisms. LEAP-2 can be used for the study of obesity and infection.
    LEAP-2
  • HY-P3466
    Nisin Z 137061-46-2
    Nisin Z is an antimicrobial and anti-inflammatory peptide. Nisin Z is effective against Gram-positive bacteria and fungi, such as C. albicans.
    Nisin Z
  • HY-P5712
    Gramicidin S 113-73-5 99.89%
    Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC50s of 41 μM, 24 μM, and 3 μM for Na+/K+-ATPase, tobacco leaf plasma membrane Mg2+/K+-ATPase, and rat heart plasma membrane Ca2+-ATPase, respectively.
    Gramicidin S
  • HY-P4855
    CRAMP (mouse) 376364-36-2 98.97%
    CRAMP (mouse) is an antibacterial peptide and a functional homolog of LL-37. CRAMP (mouse) exhibits potent antibacterial activity against Gram-negative bacteria. The complex formed by CRAMP (mouse) and CpG can activate macrophages to secrete TNF-α. CRAMP (mouse) plays a key role in wound healing, immune regulation and maintenance of intestinal homeostasis.
    CRAMP (mouse)
  • HY-P1539
    Cecropin A 80451-04-3 99.62%
    Cecropin A is a linear 37-residue antimicrobial polypeptide, with anticancer and anti-inflammatory activity.
    Cecropin A