APH-IN-1
APH-IN-1 is an Aminoglycoside phosphotransferase (APH) inhibitor with a Kd values of 63 nM against Escherichia coli APH(3′)-Ia. APH-IN-1 binds primarily to the ATP-binding pocket of APH in an ATP-competitive manner, with binding affinity enhanced by divalent metal ions (Mg2+ and Ca2+). APH-IN-1 can be used for the research of aminoglycoside-resistant bacterial infections.
For research use only. We do not sell to patients.
- Formula: C60H90N14O11S2
- Molecular Weight:1247.57
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
APH-IN-1 (Compound I-L3) (20 nM; 30 min) binds to purified Escherichia coli-derived APH(3′)-Ia with a Kd of 63 nM[1].
APH-IN-1 (20 nM; 30 min) exhibits enhanced binding to purified Escherichia coli-derived APH(3′)-Ia in the presence of divalent metal ions[1].
APH-IN-1 (20 nM) binds primarily to the ATP-binding pocket of purified Escherichia coli-derived APH(3′)-Ia, as shown by competitive displacement by ATP[1].
APH-IN-1 (0.1-5.00 μM; 1 h) inhibits the activity of purified Escherichia coli-derived APH(3′)-Ia in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Molecular Weight 1247.57
-
Formula C60H90N14O11S2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
APH-IN-1 Related Classifications
HY-P11825 Related Classifications
Powered by Bioz