2. PI3K/Akt/mTOR
  3. PI3K mTOR
  4. PI3K/mTOR Inhibitor-7

PI3K/mTOR Inhibitor-7 (Compound 19i) is a potent and dual inhibitor of PI3K/mTOR. PI3K/mTOR Inhibitor-7 shows 4.7-fold higher potency than the positive control gedatolisib (0.3 vs. 1.4 μM, IC50 values). PI3K/mTOR Inhibitor-7 significantly suppresses the PI3K/Akt/mTOR signaling pathway at 10 μM. PI3K/mTOR Inhibitor-7 has the potential for the research of cancer diseases.

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PI3K/mTOR Inhibitor-7

PI3K/mTOR Inhibitor-7 화학구조

CAS No. : 2456295-65-9

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PI3K/mTOR Inhibitor-7 Related Antibodies

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mTOR mTORC1 mTORC2

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제품 설명

PI3K/mTOR Inhibitor-7 (Compound 19i) is a potent and dual inhibitor of PI3K/mTOR. PI3K/mTOR Inhibitor-7 shows 4.7-fold higher potency than the positive control gedatolisib (0.3 vs. 1.4 μM, IC50 values). PI3K/mTOR Inhibitor-7 significantly suppresses the PI3K/Akt/mTOR signaling pathway at 10 μM. PI3K/mTOR Inhibitor-7 has the potential for the research of cancer diseases[1].

Cellular Effect
Cell Line Type Value Description References
CNE-2 IC50
6.9 μM
Compound: 19i
Antiproliferative activity against human CNE2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human CNE2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32717477]
HCT-116 IC50
0.3 μM
Compound: 19i
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32717477]
HeLa IC50
2.4 μM
Compound: 19i
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32717477]
HepG2 IC50
1.3 μM
Compound: 19i
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32717477]
MCF7 IC50
1.2 μM
Compound: 19i
Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32717477]
MDA-MB-231 IC50
4.8 μM
Compound: 19i
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32717477]
분자량

571.63

화학식

C29H33N9O4
CAS No.
SMILES

O=C(C1=CC=C2C(NC(NC3=CC=C(C4=NC(N5CCOCC5)=NC(N6CCOCC6)=N4)C=C3)=N2)=C1)N7CCOCC7
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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PI3K/mTOR Inhibitor-7 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K/mTOR Inhibitor-72456295-65-9PI3KmTORPhosphoinositide 3-kinaseMammalian target of RapamycingedatolisibcancerInhibitorinhibitorinhibit

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상품명:
PI3K/mTOR Inhibitor-7
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HY-147614
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