2456295-65-9
Chemical Structure
PI3K/mTOR Inhibitor-7
- CAS. Nr.: 2456295-65-9
- Formula:C29H33N9O4
- Molecular Weight:571.63
IUPAC Name: (2-((4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)amino)-1H-benzo[d]imidazol-6-yl)(morpholino)methanone
InChIKey: MGKJPGDRCDUPMA-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2C(NC(NC3=CC=C(C4=NC(N5CCOCC5)=NC(N6CCOCC6)=N4)C=C3)=N2)=C1)N7CCOCC7
Biological Activity: PI3K/mTOR Inhibitor-7 (Compound 19i) is a potent and dual inhibitor of PI3K/mTOR. PI3K/mTOR Inhibitor-7 shows 4.7-fold higher potency than the positive control gedatolisib (0.3 vs. 1.4 μM, IC50 values). PI3K/mTOR Inhibitor-7 significantly suppresses the PI3K/Akt/mTOR signaling pathway at 10 μM. PI3K/mTOR Inhibitor-7 has the potential for the research of cancer diseases[1].
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PI3K/mTOR Inhibitor-7 | PI3K/mTOR Inhibitor-7 (Compound 19i) is a potent and dual inhibitor of PI3K/mTOR. PI3K/mTOR Inhibitor-7 shows 4.7-fold higher potency than the positive control gedatolisib (0.3 vs. 1.4 μM, IC50 values). PI3K/mTOR Inhibitor-7 significantly suppresses the PI3K/Akt/mTOR signaling pathway at 10 μM. PI3K/mTOR Inhibitor-7 has the potential for the research of cancer diseases. | |||||||||||||||||||||
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