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Cat. No.: HY-147614

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PI3K/mTOR Inhibitor-7

PI3K/mTOR Inhibitor-7 (Compound 19i) is a potent and dual inhibitor of PI3K/mTOR. PI3K/mTOR Inhibitor-7 shows 4.7-fold higher potency than the positive control gedatolisib (0.3 vs. 1.4 μM, IC₅₀ values). PI3K/mTOR Inhibitor-7 significantly suppresses the PI3K/Akt/mTOR signaling pathway at 10 μM. PI3K/mTOR Inhibitor-7 has the potential for the research of cancer diseases.

For research use only. We do not sell to patients.

CAS No.: 2456295-65-9
Formula: C₂₉H₃₃N₉O₄
Molecular Weight:571.63

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

PI3K/mTOR Inhibitor-7 Chemical Structure

CAS No.: 2456295-65-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
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Classifications
Bioz

Biological Activity

Description

All PI3K Isoforms :

All mTOR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CNE-2	IC₅₀	6.9 μM Compound: 19i	Antiproliferative activity against human CNE2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human CNE2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32717477]
HCT-116	IC₅₀	0.3 μM Compound: 19i	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32717477]
HeLa	IC₅₀	2.4 μM Compound: 19i	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32717477]
HepG2	IC₅₀	1.3 μM Compound: 19i	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32717477]
MCF7	IC₅₀	1.2 μM Compound: 19i	Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32717477]
MDA-MB-231	IC₅₀	4.8 μM Compound: 19i	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32717477]

Chemical Information

CAS No. 2456295-65-9
Molecular Weight 571.63
Formula C₂₉H₃₃N₉O₄
SMILES

O=C(C1=CC=C2C(NC(NC3=CC=C(C4=NC(N5CCOCC5)=NC(N6CCOCC6)=N4)C=C3)=N2)=C1)N7CCOCC7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang L, et al. Design, synthesis and bioevaluation of novel substituted triazines as potential dual PI3K/mTOR inhibitors. Eur J Med Chem. 2020 Oct 15;204:112637 [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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PI3K/mTOR Inhibitor-7

All PI3K Isoforms

All mTOR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PI3K/mTOR Inhibitor-7 Related Classifications

HY-147614 Related Classifications