2. Cell Cycle/DNA Damage Anti-infection
  3. Antibiotic DNA/RNA Synthesis Bacterial Nucleoside Antimetabolite/Analog
  4. Pseudouridimycin

Pseudouridimycin (PUM) is an antibiotic that selectively inhibits bacterial RNA polymerase (RNAP), with an IC50 of about 0.1 μM and MICs of 4-6 μg/mL. Pseudouridimycin is a C-nucleoside analogue that's effective against both Gram-negative and Gram-positive bacteria. Pseudouridimycin inhibits bacterial growth in vitro and shows activity in a mouse model of purulent streptococcal peritonitis.

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Pseudouridimycin

Pseudouridimycin Estructura química

No. CAS : 1566586-52-4

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Pseudouridimycin Related Antibodies

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1 Publications Citing Use of MCE Pseudouridimycin

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Descripciòn

Pseudouridimycin (PUM) is an antibiotic that selectively inhibits bacterial RNA polymerase (RNAP), with an IC50 of about 0.1 μM and MICs of 4-6 μg/mL. Pseudouridimycin is a C-nucleoside analogue that's effective against both Gram-negative and Gram-positive bacteria. Pseudouridimycin inhibits bacterial growth in vitro and shows activity in a mouse model of purulent streptococcal peritonitis[1][2].

IC50 & Target

RNA Polymerase

 

In Vitro

Pseudouridimycin (PUM) is selective because of its side chain that binds in a region that is conserved in bacterial RNA polymerases but not in humans. In vitro bactericidal activity is reported for Pseudouridimycin against drug-sensitive, drug-resistant, and multidrug-resistant Streptococcus species[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pseudouridimycin Related Antibodies
In Vivo

Pseudouridimycin (3.2-50 mg/kg; iv; 10 min after infection and again 6 h after infection) clears infection in vivo in a mouse Streptococcus pyogenes peritonitis model (ED50 = 9 mg/kg)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female ICR mice (23-25 g) intraperitoneal injection of 0.5 mL saline solution (supplemented with 1% peptone) containing 4 × 103 cfu S. pyogenes C203[3].
Dosage: 3.2 mg/kg, 8 mg/kg, 20 mg/kg, 50 mg/kg
Administration: iv; 10 min after infection and again 6 h after infection
Result: Showed antibacterial activity in vivo.
Peso molecular

486.44

Fòrmula

C17H26N8O9
No. CAS
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1NC(C([C@H]2[C@@H]([C@@H]([C@@H](CNC([C@H](CCC(N)=O)N(C(CNC(N)=N)=O)O)=O)O2)O)O)=CN1)=O
Structure Classification
Initial Source

treptomyces sp
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Pureza y Documentación

Purity: ≥96.0%

SDS (251 KB)

COA (252 KB) HNMR (132 KB) MS (165 KB)

Instrucciones de manejo (2659 KB)
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Pseudouridimycin Related Classifications

  • Calculadora de molaridad

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pseudouridimycin1566586-52-4PUMAntibioticDNA/RNA SynthesisBacterialNucleoside Antimetabolite/AnalogInhibitorinhibitorinhibit

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Nombre del producto:
Pseudouridimycin
Cat. No.:
HY-125650
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SAFETY DATA SHEET (SDS)

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