(rel)-Eglumegad (Synonyms: (rel)-LY354740; (rel)-Eglumetad)

Name: (rel)-Eglumegad
Brand: MedChemExpress
SKU: HY-18941B
Rating: 4.5 (0 reviews)

Cat. No.: HY-18941B Purity: 97.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

(rel)-Eglumegad ((rel)-LY354740) is a relative configuration of Eglumegad (HY-18941). Eglumegad is a highly potent and selective group II (mGlu2/3) receptor agonist with EC₅₀s of 5 and 24 nM for transfected human mGlu2 and mGlu3 receptors, respectively.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

(rel)-Eglumegad 화학구조

CAS No. : 176027-90-0

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of (rel)-Eglumegad:

Eglumegad In-stock
Eglumegad hydrochloride In-stock

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All mGluR Isoform Specific Products:

View All Isoforms

mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

mGluR2^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	IC₅₀	>10 2 Compound: 1	Inhibition of radiolabeled glycylsarcosine (Gly-Sar) uptake into Caco-2 cells done for 15 min at 37 degree C with compound Inhibition of radiolabeled glycylsarcosine (Gly-Sar) uptake into Caco-2 cells done for 15 min at 37 degree C with compound	[PMID: 16078848]
Caco-2	IC₅₀	> 10 2 Compound: 1	Inhibition of radiolabeled glycylsarcosine (Gly-Sar) uptake into Caco-2 cells done for 15 min at 37 degree C with compound Inhibition of radiolabeled glycylsarcosine (Gly-Sar) uptake into Caco-2 cells done for 15 min at 37 degree C with compound	[PMID: 16078848]
CHO	EC₅₀	18.3 1 Compound: 4, LY-354740	Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formation Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formation	[PMID: 11123999]
HEK293	EC₅₀	>100 3 Compound: 19	Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive	[PMID: 15801843]
HEK293	EC₅₀	> 100 3 Compound: 19	Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive	[PMID: 15801843]
HEK293	IC₅₀	458 3 Compound: 17	Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells. Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.	[PMID: 10229625]
CHO	EC₅₀	18.3 1 Compound: 4, LY-354740	Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formation Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formation	[PMID: 11123999]

분자량

185.18

화학식

C₈H₁₁NO₄

CAS No.

176027-90-0

Appearance

Solid

Color

White to off-white

SMILES

OC([C@]1([C@]2([H])[C@@H](C(O)=O)[C@]2([H])CC1)N)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

H₂O : 16.67 mg/mL (90.02 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.4002 mL	27.0008 mL	54.0015 mL
5 mM	1.0800 mL	5.4002 mL	10.8003 mL
10 mM	0.5400 mL	2.7001 mL	5.4002 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 97.0%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (248 KB) HNMR (75 KB)

Handling Instructions (2659 KB)

References

[1]. Boerner T, et al. The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice. Eur J Neurosci. 2017 Apr;45(7):912- [Content Brief]

[2]. Orlando R, et al. Levels of the Rab GDP dissociation inhibitor (GDI) are altered in the prenatal restrain stress mouse model of schizophrenia and are differentially regulated by the mGlu2/3 receptor agonists, LY379268 and LY354740. Neuropharmacology. 2014 [Content Brief]

[3]. Procaccini C, et al. Reversal of novelty-induced hyperlocomotion and hippocampal c-Fos expression in GluA1 knockout male mice by the mGluR2/3 agonist LY354740. Neuroscience. 2013 Oct 10;250:189-200 [Content Brief]

[4]. Lee Y, et al. The mGlu2/3 receptor agonist LY354740 suppresses immobilization stress-induced increase in rat prefrontal cortical BDNF mRNA expression. Neurosci Lett. 2006 May 8;398(3):328-32. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.4002 mL	27.0008 mL	54.0015 mL	135.0038 mL
	5 mM	1.0800 mL	5.4002 mL	10.8003 mL	27.0008 mL
	10 mM	0.5400 mL	2.7001 mL	5.4002 mL	13.5004 mL
	15 mM	0.3600 mL	1.8001 mL	3.6001 mL	9.0003 mL
	20 mM	0.2700 mL	1.3500 mL	2.7001 mL	6.7502 mL
	25 mM	0.2160 mL	1.0800 mL	2.1601 mL	5.4002 mL
	30 mM	0.1800 mL	0.9000 mL	1.8001 mL	4.5001 mL
	40 mM	0.1350 mL	0.6750 mL	1.3500 mL	3.3751 mL
	50 mM	0.1080 mL	0.5400 mL	1.0800 mL	2.7001 mL
	60 mM	0.0900 mL	0.4500 mL	0.9000 mL	2.2501 mL
	80 mM	0.0675 mL	0.3375 mL	0.6750 mL	1.6875 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

(rel)-Eglumegad Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(rel)-Eglumegad176027-90-0(rel)-LY354740 (rel)-EglumetadmGluRMetabotropic glutamate receptorsTinnitusanxietypanic disorderInhibitorinhibitorinhibit

최근 본 상품:

상품명

Requested Quantity *

고객명 *

호칭

메일주소 *

전화번호 *

Department

회사명 *

City

도

Country or Region *

비고

상품명

Lot #

고객명 *

메일주소 *

전화번호

Department *

회사명 *

Country or Region *

비고

Name
이메일 *

	Sorry, but the email address you supplied was invalid.

(rel)-Eglumegad (Synonyms: (rel)-LY354740; (rel)-Eglumetad)

고객리뷰

Other Forms of (rel)-Eglumegad:

(rel)-Eglumegad Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All mGluR Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

(rel)-Eglumegad Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report