Eglumegad hydrochloride
Based on 4 publication(s) in Google Scholar
Eglumegad (LY354740) hydrochloride is a highly potent and selective group II (mGlu2/3) receptor agonist with IC50s of 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively. Eglumegad hydrochloride protects neurons from NMDA toxicity. Eglumegad hydrochloride has anxiolytic- and antipsychotic-like effects.
For research use only. We do not sell to patients.
- Purity: 95.0%
- Formula: C8H12ClNO4
- Molecular Weight:221.64
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Eglumegad hydrochloride
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Biological Activity
Chemical Information
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Appearance Solid
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Molecular Weight 221.64
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Formula C8H12ClNO4
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Color White to off-white
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SMILES
OC([C@]1([C@]2([H])[C@@H](C(O)=O)[C@]2([H])CC1)N)=O.[H]Cl
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Synonyms
LY354740 hydrochloride; Eglumetad hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (4)
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Journal Impact Factor
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Most Recent
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Cell Res
2025 Mar;35(3):165-185. PMID: 39875551 -
Neurobiol Dis
Distinct anti-dyskinetic effects of amantadine and group II metabotropic glutamate receptor agonist LY354740 in a rodent model: An electrophysiological perspective. [Abstract]2020 Jun:139:104807. PMID: 32088382 -
Front Pharmacol
LY354740 Reduces Extracellular Glutamate Concentration, Inhibits Phosphorylation of Fyn/NMDARs, and Expression of PLK2/pS129 α-Synuclein in Mice Treated With Acute or Sub-Acute MPTP. [Abstract]2020 Feb 28:11:183. PMID: 32180729 -
Pharmacol Biochem Behav
Activation of mGlu2/3 receptors in the striatum alleviates L-DOPA-induced dyskinesia and inhibits abnormal postsynaptic molecular expression. [Abstract]2023 Oct:231:173637. PMID: 37714223
Solvent & Solubility
H2O : 175 mg/mL (789.57 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Boerner T, et al. The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice. Eur J Neurosci. 2017 Apr;45(7):912- [Content Brief]
[2]. Orlando R, et al. Levels of the Rab GDP dissociation inhibitor (GDI) are altered in the prenatal restrain stress mouse model of schizophrenia and are differentially regulated by the mGlu2/3 receptor agonists, LY379268 and LY354740. Neuropharmacology. 2014 [Content Brief]
[3]. Procaccini C, et al. Reversal of novelty-induced hyperlocomotion and hippocampal c-Fos expression in GluA1 knockout male mice by the mGluR2/3 agonist LY354740. Neuroscience. 2013 Oct 10;250:189-200 [Content Brief]
[4]. Lee Y, et al. The mGlu2/3 receptor agonist LY354740 suppresses immobilization stress-induced increase in rat prefrontal cortical BDNF mRNA expression. Neurosci Lett. 2006 May 8;398(3):328-32. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.5118 mL | 22.5591 mL | 45.1182 mL | 112.7955 mL |
| 5 mM | 0.9024 mL | 4.5118 mL | 9.0236 mL | 22.5591 mL | |
| 10 mM | 0.4512 mL | 2.2559 mL | 4.5118 mL | 11.2796 mL | |
| 15 mM | 0.3008 mL | 1.5039 mL | 3.0079 mL | 7.5197 mL | |
| 20 mM | 0.2256 mL | 1.1280 mL | 2.2559 mL | 5.6398 mL | |
| 25 mM | 0.1805 mL | 0.9024 mL | 1.8047 mL | 4.5118 mL | |
| 30 mM | 0.1504 mL | 0.7520 mL | 1.5039 mL | 3.7599 mL | |
| 40 mM | 0.1128 mL | 0.5640 mL | 1.1280 mL | 2.8199 mL | |
| 50 mM | 0.0902 mL | 0.4512 mL | 0.9024 mL | 2.2559 mL | |
| 60 mM | 0.0752 mL | 0.3760 mL | 0.7520 mL | 1.8799 mL | |
| 80 mM | 0.0564 mL | 0.2820 mL | 0.5640 mL | 1.4099 mL | |
| 100 mM | 0.0451 mL | 0.2256 mL | 0.4512 mL | 1.1280 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Eglumegad hydrochloride Related Classifications
HY-18941C Related Classifications
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