1. Cell Cycle/DNA Damage Epigenetics
  2. HDAC
  3. (S)-Trichostatin A

(S)-Trichostatin A ((S)-TSA) is a HDAC6-selective inhibitor with IC50s of 9.88 nM and 11.1 nM for Zebrafish HDAC6 and Human HDAC6, respectively. (S)-Trichostatin A weakly inhibits other human HDACs.

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(S)-Trichostatin A

(S)-Trichostatin A Chemical Structure

CAS No. : 122292-85-7

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Description

(S)-Trichostatin A ((S)-TSA) is a HDAC6-selective inhibitor with IC50s of 9.88 nM and 11.1 nM for Zebrafish HDAC6 and Human HDAC6, respectively. (S)-Trichostatin A weakly inhibits other human HDACs[1].

IC50 & Target[1]

hHDAC6

11.1 nM (IC50)

Zebrafish HDAC6

9.88 nM (IC50)

hHDAC1

206.3 nM (IC50)

hHDAC2

612.65 nM (IC50)

hHDAC3

320.8 nM (IC50)

hHDAC4

6341 nM (IC50)

hHDAC5

6325 nM (IC50)

hHDAC7

1823.5 nM (IC50)

hHDAC8

312.2 nM (IC50)

hHDAC9

4824 nM (IC50)

hHDAC10

403.35 nM (IC50)

hHDAC11

2684 nM (IC50)

Masse moléculaire

302.37

Formule

C17H22N2O3

CAS No.
SMILES

ONC(/C=C/C(C)=C/[C@H](C)C(C1=CC=C(C=C1)N(C)C)=O)=O

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation
Références
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Nom du produit:
(S)-Trichostatin A
Cat. No.:
HY-15144B
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