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Results for "

AES

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Acetolactate Synthase (ALS) (1) Akt (3) Apoptosis (3) Biochemical Assay Reagents (2) Calcium Channel (1) Cholinesterase (ChE) (1) Deubiquitinase (2) Drug Derivative (1) Elastase (1) Endogenous Metabolite (1) Epigenetic Reader Domain (1) FLT3 (1) HDAC (3) Herbicide (1) Histone Demethylase (1) HIV Protease (1) Insecticide (1) Isotope-Labeled Compounds (1) JAK (2) mAChR (3) MicroRNA (4) nAChR (1) NKCC (1) NO Synthase (1) Parasite (1) PD-1/PD-L1 (2) PI3K (3) PKC (1) Potassium Channel (1) Prostaglandin Receptor (6) Radionuclide-Drug Conjugates (RDCs) (1) Reference Standards (2) Ser/Thr Protease (2) Small Interfering RNA (siRNA) (1) Sodium Channel (1) STAT (2) TGF-beta/Smad (1) Transmembrane Glycoprotein (2) TROP2 (1)
By Research Areas:	Cancer (18) Cardiovascular Disease (6) Endocrinology (3) Infection (3) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (8)
Oligonucleotides:	miRNA mimics (1) miRNA antagomirs (1) miRNA agomirs (1) MicroRNAs (4) miRNA inhibitors (1) Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-50901

ONO-AE3-208 Maximum Cited Publications 12 Publications Verification AE 3-208	Prostaglandin Receptor	Endocrinology Cancer
ONO-AE3-208 is a selective and orally active EP4 receptor antagonist with a K_i of 1.3 nM. ONO-AE3-208 shows less potently affects EP3, FP, and TP receptors (K_i of 30 nM, 790 nM, and 2400 nM, respectively). ONO-AE3-208 suppresses cell invasion, migration, and metastasis of prostate cancer .

HY-114974

Rivenprost ONO-4819; ONO-AE1-734	Prostaglandin Receptor	Others Inflammation/Immunology
Rivenprost (ONO-4819; ONO-AE1-734) is a selective agonist for prostaglandin E receptor EP4 with K_i of 0.7 nM. Rivenprost exhibits hepatoprotective and bone anabolic effects .

HY-19406

AE-3763	Elastase	Cardiovascular Disease Inflammation/Immunology
AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC₅₀ of 29 nM.

HY-151527

PI3K/Akt/CREB activator 1 4 Publications Verification	Akt PI3K Epigenetic Reader Domain	Neurological Disease
PI3K/Akt/CREB activator 1 (compound AE-18) is a potent, orally active PI3K/Akt/CREB activator. PI3K/Akt/CREB activator 1 promotes neuronal proliferation, induced differentiation of Neuro-2a cells into a neuron-like morphology, and accelerated the establishment of axon-dendrite polarization of primary hippocampal neurons through upregulating brain-derived neurotrophic factor via the PI3K/Akt/CREB pathway. PI3K/Akt/CREB activator 1 can be used in research of vascular dementia (VaD) .

HY-114483

AES-135 1 Publications Verification	HDAC	Cancer
AES-135, a hydroxamic acid-based pan-HDAC inhibitor, prolongs survival in an orthotopic mouse model of pancreatic cancer. AES-135 inhibits HDAC3, HDAC6, HDAC8, and HDAC11 with IC₅₀s ranging from 190-1100 nM .

HY-P99359

Elezanumab ABT-555; AE12-1Y-QL; Anti-RGMA Reference Antibody (elezanumab)	TGF-beta/Smad	Metabolic Disease
Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC₅₀ around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism .

HY-P5018

NOTA-AE105	Radionuclide-Drug Conjugates (RDCs) Ser/Thr Protease	Cancer
NOTA-AE105 is a PET ligand for the urokinase-type plasminogen activator receptor (uPAR). NOTA-AE105 can be radiolabeled with ⁶⁴Cu and ⁶⁸Ga. Images of 68Ga-NOTA-AE105 and 64Cu-NOTA-AE105 demonstrate high contrast and clear tumor delineation. NOTA-AE105 can be used in the synthesis of radionuclide-conjugated compounds (RDCs) .

HY-P11446

AE105	Transmembrane Glycoprotein	Cancer
AE105 is a 9-mer peptide probe targeting the urokinase-type plasminogen activator receptor (uPAR). AE105 binds tightly to the uPA-binding cavity of uPAR. AE105 can be used for the study of cancer .

HY-W131444

Insecticidal agent 15	Insecticide	Others
Insecticidal agent 15 (compound 8f) is a potent insecticidal agent that shows LD₅₀ of 4.27 nmol/mg for adult female Ae. Aegypti .

HY-118607

VU041	Potassium Channel Parasite	Infection
VU041 is a first submicromolar-affinity inhibitor of *Anopheles (An.) gambiae* and Aedes (Ae.) aegypti inward rectifier potassium 1 (Kir1) channels with IC₅₀ values of 2.5 μM and 1.7 μM, respectively. VU041 inhibits appreciably is mammalian Kir2.1 (IC₅₀ of 12.7 μM), and has less inhibitory effect on mammalian Kir1.1, Kir4.1, Kir6.2/SUR1, and Kir7.1. VU041 also induces impaired Malpighian tubule function .

HY-133910

Lu AE98134 1 Publications Verification	Sodium Channel	Neurological Disease
Lu AE98134, an activator of voltage-gated sodium channels, acts as a partly selective Na_v1.1 channels positive modulator. Lu AE98134 also increases the activity of Na_v1.2 and Na_v1.5 channels but not of Na_v1.4, Na_v1.6 and Na_v1.7 channels. Lu AE98134 can be used to analyze pathophysiological functions of the Na_v1.1 channel in various central nervous system diseases, including cognitive restoring in schizophrenia, et al .

HY-14338A

Idalopirdine hydrochloride Lu AE58054 hydrochloride	5-HT Receptor	Neurological Disease
Idalopirdine hydrochloride (Lu AE58054 hydrochloride) is a potent, selective 5-HT6 receptor antagonist with a K_i value of 0.83 nM. Idalopirdine hydrochloride may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders .

HY-12184

ONO-AE 248	Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease
ONO-AE 248 is a selective EP3 receptor agonist with cardioprotective activity. ONO-AE 248 reduces myocardial infarction size by selectively binding to the EP3α receptor in mice. The cardioprotective effect of ONO-AE 248 is independent of hemodynamic effects. The mechanism of ONO-AE 248 may involve activation of protein kinase C and opening of K(ATP) channels .

HY-118363

Lu AE51090	mAChR	Neurological Disease
Lu AE51090 is selective muscarinic M1 receptor agonist with blood-brain barrier penetration. Lu AE51090 activates human M1 receptor with EC₅₀ of 61 nM, while showing no significant agonism at M2-M5 receptors. Lu AE51090 exerts procognitive effects in mice. Lu AE51090 can be used for the study of Alzheimer’s disease (AD) and cognitive impairment associated with schizophrenia (CIAS) .

HY-178500

WCY-8-67	Deubiquitinase Apoptosis STAT JAK Akt PI3K	Cancer
WCY-8-67 is an orally active and selective USP5 inhibitor, with an IC₅₀ value of 1.33 μM. WCY-8-67 induces apoptosis and suppresses JAK/STAT3 and PI3K/AKT signaling pathways in vitro. WCY-8-67 inhibits proliferation of AE-positive AML cells, induces G1 phase arrest and differentiation of AML cells. WCY-8-67 demonstrates potent anti-leukemic efficacy in mice. WCY-8-67 can be used for the study of acute myeloid leukemia .

HY-131929

AE-ITU dihydrobromide	NO Synthase	Inflammation/Immunology
AE-ITU dihydrobromide is the dihydrobromide form of AE-ITU. AE-ITU dihydrobromide is a selective inhibitor for inducible NO synthase (iNOS), and attenuates the liver dysfunction caused by endotoxaemia in rats .

HY-138831

AES-350	HDAC Apoptosis	Cancer
AES-350 is a potent and orally active HDAC6 inhibitor with an IC₅₀ and a K_i of 0.0244 μM and 0.035 μM, respectively. AES-350 is also against HDAC3, HDAC8 in an enzymatic activity assay with IC₅₀ values of 0.187 μM and 0.245 μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research .

HY-14338

Idalopirdine Lu AE58054	5-HT Receptor	Neurological Disease
Idalopirdine (Lu AE58054 ) is a potent, selective 5-HT6 receptor antagonist with a K_i value of 0.83 nM. Idalopirdine may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders .

HY-120004

PF-06827443	mAChR	Infection
PF-06827443 is a potent, low-clearance, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with minimal agonist activity. PF-06827443 induce cholinergic AEs and convulsion .

HY-131829

N6-(2-Aminoethyl)-NAD+ 6-AE-NAD+	Biochemical Assay Reagents	Others
N6-(2-Aminoethyl)-NAD+ (6-AE-NAD+) is a NAD+ derivative commonly used in affinity chromatography. N6-(2-Aminoethyl)-NAD+ can be covalently linked to a PQQ (pyrroloquinoline quinone) (HY-100196) monolayer on an electrode surface for immobilizing NAD+-dependent enzymes such as lactate dehydrogenase (LDH) .

HY-178500A

WCY-8-67 TFA	Deubiquitinase Apoptosis STAT JAK Akt PI3K	Cancer
WCY-8-67 TFA is an orally active and selective USP5 inhibitor, with an IC₅₀ value of 1.33 μM. WCY-8-67 TFA induces apoptosis and suppresses JAK/STAT3 and PI3K/AKT signaling pathways. WCY-8-67 TFA inhibits proliferation of AE-positive AML cells, induces G1 phase arrest and differentiation of AML cells. WCY-8-67 TFA demonstrates potent anti-leukemic efficacy in mice. WCY-8-67 TFA can be used for the study of acute myeloid leukemia .

HY-P11446A

AE105 TFA	Transmembrane Glycoprotein	Cancer
AE105 TFA is a 9-mer peptide probe targeting the urokinase-type plasminogen activator receptor (uPAR). AE105 TFA binds tightly to the uPA-binding cavity of uPAR. AE105 TFA can be used for the study of cancer .

HY-121727

Triafamone AE 1887196; BCS-BX60309	Acetolactate Synthase (ALS)	Others
Triafamone (AE 1887196) is a paddy field pre-emergence and post-emergence sulfonamide herbicide. Triafamone weeds by inhibiting the acetolactate synthase (ALS) enzyme, thereby blocking the biosynthesis of branched-chain amino acids .

HY-W042301R

Xipamide (Standard)	NKCC Reference Standards	Cardiovascular Disease
Xipamide (Standard) is the analytical standard of Xipamide. This product is intended for research and analytical applications. Xipamide is a sulfonamide-based diuretic. Xipamide is an antihypertensive agent able to selectively inhibit the anion exchanger (AE) .

HY-164428

AE 51310	PKC	Cancer
AE 51310 is an OPN4 inhibitor. AE 51310 inhibits the activation of PKC and the downstream BRAF/MEK/ERKs signaling pathway. AE 51310 can be used for cancer research, such as NSCLC .

HY-50901A

ONO-AE3-208 sodium salt AE 3-208 sodium salt	Prostaglandin Receptor	Endocrinology Cancer
ONO-AE3-208 (sodium salt) is a selective and orally active EP4 receptor antagonist with a K_i of 1.3 nM. ONO-AE3-208 (sodium salt) shows less potently affects EP3, FP, and TP receptors (K_i of 30 nM, 790 nM, and 2400 nM, respectively). ONO-AE3-208 (sodium salt) suppresses cell invasion, migration, and metastasis of prostate cancer .

HY-RS14567

TLE5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TLE5 Human Pre-designed siRNA Set A contains three designed siRNAs for TLE5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TLE5 Human Pre-designed siRNA Set A TLE5 Human Pre-designed siRNA Set A

HY-R01638

hsa-miR-548ae-3p mimic	MicroRNA	Cancer
hsa-miR-548ae-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-548ae-3p mimic hsa-miR-548ae-3p mimic

HY-U00284

AE0047 Hydrochloride	Calcium Channel	Cardiovascular Disease
AE0047 Hydrochloride is a calcium blocker, used in the research of hypertensive disease.

HY-N12273

Soyasaponin Ae Acetyl-soyasaponin A5	Others	Others
Soyasaponin Ae (Acetyl-soyasaponin A5) can be isolated from the seeds of Glycine max MERRILL .

HY-163662

AE027	Cholinesterase (ChE)	Neurological Disease
AE027 is a potent inhibitor against both WT and resistant mutation F348Y AChE with the IC₅₀ values of 10 and 43 μM, respectively .

HY-122240

AAE871	FLT3	Cancer
AAE871 is a potent type I FLT3 inhibitor with an IC₅₀ value of 0.034 µM. AE871 has the potential for the research of acute myeloid leukemia (AML) .

HY-167103A

ONO-8815Ly ONO-AE1-259	Prostaglandin Receptor	Endocrinology
ONO-8815Ly (ONO-AE1-259) is a selective EP2 receptor agonist. ONO-8815Ly inhibits spontaneous uterine contractility .

HY-134971

AE9C90CB	mAChR	Neurological Disease
AE9C90CB, muscarinic receptor antagonist, has greater affinity for M3 muscarinic receptors with pK_i of 9.90 and was 20-fold more selective for M3 than for M2 muscarinic receptors .

HY-106699

Taprostene sodium CG 4203 sodium	Prostaglandin Receptor nAChR	Cardiovascular Disease
Taprostene sodium is a partial agonist at prostanoid prostacyclin (IP) receptors. Taprostene sodium interacts additively with Prostaglandin E2 (PGE2) (HY-101952), ONO-AE1-259 (selective EP2 agonist), and acetylcholine. Taprostene sodium exerts a significant cardioprotection .

HY-14338AR

Idalopirdine hydrochloride (Standard) Lu AE58054 hydrochloride (Standard)	5-HT Receptor Reference Standards	Neurological Disease
Idalopirdine (hydrochloride) (Standard) is the analytical standard of Idalopirdine (hydrochloride). This product is intended for research and analytical applications. Idalopirdine hydrochloride (Lu AE58054 hydrochloride) is a potent, selective 5-HT6 receptor antagonist with a Ki value of 0.83 nM. Idalopirdine hydrochloride may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders .

HY-169166

HIV-1 protease-IN-14	HIV Protease	Infection
HIV-1 protease-IN-14 (compound 5ae) is a potent HIV-1 protease inhibitor with K_i values of 0.28, 56.9 nM for WT HIV-1 PR, R41T HIV-1 PR, respectively. HIV-1 protease-IN-14 shows low cytotoxicity .

HY-172601

HDAC3-IN-7	HDAC PD-1/PD-L1	Cancer
HDAC3-IN-7 (Compound 8ae) is a selective HDAC3 inhibitor with an IC₅₀ value of 311 nM. HDAC3-IN-7 degrades PD-L1 through the lysosome pathway mediated by Cathepsin B, exerting activities such as inhibiting tumor cell proliferation, migration, and invasion. HDAC3-IN-7 is promising for research of cancers .

HY-172809

LSD1-IN-42	Histone Demethylase PD-1/PD-L1	Inflammation/Immunology Cancer
LSD1-IN-42 (Compound 7ae) is an orally active LSD1 inhibitor that potently inhibits LSD1 activity (IC₅₀ = 0.08 μM). LSD1-IN-42 downregulates PD-L1 expression and enhances T cell-mediated tumor killing effects. LSD1-IN-42 demonstrates significant anti-gastric cancer activity by inhibiting tumor cell invasion and migration .

HY-N8978

Poricoic acid AE	Drug Derivative	Others
Poricoic acid AE is a natural triterpene.

HY-RI01638

hsa-miR-548ae-3p inhibitor	MicroRNA	Cancer
hsa-miR-548ae-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-548ae-3p inhibitor hsa-miR-548ae-3p inhibitor

HY-R01638A

hsa-miR-548ae-3p agomir	MicroRNA	Cancer
hsa-miR-548ae-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-548ae-3p agomir hsa-miR-548ae-3p agomir

HY-W042301S

Xipamide-d6	Isotope-Labeled Compounds	Cardiovascular Disease
Xipamide-d₆ is the deuterium labeled Xipamide. Xipamide is a sulfonamide-based diuretic. Xipamide is an antihypertensive agent able to selectively inhibit the anion exchanger (AE) .

HY-138156

Iodosulfuron-methyl sodium	Herbicide	Others
Iodosulfuron-methyl sodium is a sulfonylurea herbicide. Iodosulfuron-methyl sodium controls grass weeds in winter wheat and winter barley .

HY-N19612

Proteasefrom aspergillus oryzae	Ser/Thr Protease	Others
Proteasefrom aspergillus oryzae is a serine protease identified in the non-transgenic Aspergillus ochraceus strain AE-P. Proteasefrom aspergillus oryzae functions as a food enzyme and catalyzes protein hydrolysis with broad-spectrum specificity .

HY-RI01638A

hsa-miR-548ae-3p antagomir	MicroRNA	Cancer
hsa-miR-548ae-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-548ae-3p antagomir hsa-miR-548ae-3p antagomir

HY-131829A

N6-(2-Aminoethyl)-NAD+ sodium 6-AE-NAD+ sodium	Biochemical Assay Reagents	Others
N6-(2-Aminoethyl)-NAD+ (6-AE-NAD+) sodium is a NAD+ derivative commonly used in affinity chromatography. N6-(2-Aminoethyl)-NAD+ sodium can be covalently linked to a PQQ (pyrroloquinoline quinone) (HY-100196) monolayer on an electrode surface for immobilizing NAD+-dependent enzymes such as lactate dehydrogenase (LDH) .

HY-P992367

hIMB1636	TROP2	Cancer
hIMB1636 is a humanized monoclonal antibody targeting Trop2. By binding to the conformational Trop2 epitope, hIMB1636 regulates related signaling pathways, triggers lysosomal endocytosis, and further induces apoptosis, cell cycle arrest, and antibody-dependent cellular cytotoxicity. hIMB1636 effectively inhibits tumor cell proliferation, migration and in vivo tumor growth, and also exerts bystander killing effect and mediates long-term retention. hIMB1636 can be conjugated with NOTA/DOTA for radiolabeling to enable immuno-PET imaging, or prepared as hIMB1636-LDP-AE to significantly inhibit the growth of breast cancer and lung cancer xenografts .

Cat. No.	Product Name	Target	Research Area