TROP2

TROP2 is a transmembrane glycoprotein that belongs to the GA733 family. Trop2 has several ligands, including claudin-1, claudin-7, and cyclin D1. Trop2 activity requires regulated intramembrane proteolysis (RIP). RIP cleaves Trop2 by TNF-α converting enzyme (TACE), followed by γ-secretase cleavage within the transmembrane domain. TROP2 can activate the ERK1/3-MAPK pathway. TROP2 signals cells to self-renewal, proliferation, invasion, and survival. Trop2 has stem cell-like properties. TROP2 is overexpressed in a variety of human cancers, including breast, cervical, colorectal, esophageal (some types), lung (some types), non-Hodgkin lymphoma, chronic lymphocytic lymphoma (CLL), Rajburkitt's lymphoma, oral squamous cell carcinoma, ovarian, pancreatic, prostate, gastric, thyroid, bladder, and uterine cancers.