Anti-TROP-2 Antibody (Pr1E11)
Based on 1 Customer Validation
Anti-TROP-2 Antibody (Pr1E11) is a kind of mouse IgG1 κ chimeric antibody inhibitor, targeting to human TROP-2. Anti-TROP-2 Antibody (Pr1E11) specifically binds to TROP-2 with high affinity and shows low internalization activitv. Anti-TROP-2 Antibody (Pr1E11) can be used for the research of cancer, such as epithelial cancer and primary pancreatic cancer.
For research use only. We do not sell to patients.
- Purity: 95.00%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Mouse IgG1 kappa
Human
TROP-2
Anti-TROP-2 Antibody (Pr1E11) (defucosylated [Fuc(−)] chimeric Pr1E11) (0.1-1,000 ng/mL, 4 h) shows antibody-dependent cellular cytotoxicity (ADCC) activity but not complement-dependent cytotoxicity (CDC) activity in BxPC3 and Colo205 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BxPC3/Colo205 tumor SCID mice[1]
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Dosage:200 μg
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Administration:Intraperitoneally injection, twice a week for 4 weeks
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Result:Suppressed tumor growth.
Showed the minimum tumor growth inhibition ratio (T/Cmin) with 0.36 and 0.29, respectively.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
Western blot; Immunohistochemistry (frozen); Flow cytometry
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Flow cytometric analysis of 1×106 MCF-7 cells with Anti-TROP-2 Antibody (Pr1E11) (HY-P990827, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Mouse IgG1 kappa Isotype Control (HY-P99977, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-TROP-2 Antibody (Pr1E11)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (259 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)