N6-(2-Aminoethyl)-NAD+
N6-(2-Aminoethyl)-NAD+ (6-AE-NAD+) is an adenine-modified NAD analog with coenzyme activity and the property of targeting lactate dehydrogenase (LDH). N6-(2-Aminoethyl)-NAD+ undergoes transient affinity binding with LDH, thereby crosslinking the enzyme monolayer into an integrated electrode. N6-(2-Aminoethyl)-NAD+ is a component of the PQQ (HY-100196)-NAD+ binary interface, and supports the bioelectrocatalytic oxidation of lactate through PQQ-mediated immobilized NADH oxidation.
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- CAS No.: 59587-50-7
- Formula: C23H32N8O14P2
- Molecular Weight:706.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
N6-(2-Aminoethyl)-NAD+ can be covalently linked to a PQQ monolayer on the electrode surface for the immobilization of NAD+-dependent enzymes such as lactate dehydrogenase[1].
N6-(2-Aminoethyl)-NAD+ acts as a coenzyme for porcine heart lactate dehydrogenase isoenzyme H4[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 59587-50-7
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Molecular Weight 706.49
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Formula C23H32N8O14P2
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SMILES
O[C@@H]1[C@H](O)[C@@H](COP(OP(OC[C@H]2O[C@@H]([N+]3=CC=CC(C(N)=O)=C3)[C@H](O)[C@@H]2O)([O-])=O)(O)=O)O[C@H]1N(C=N4)C5=C4C(NCCN)=NC=N5
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Synonyms
6-AE-NAD+
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Katz E, et al. Fully integrated biocatalytic electrodes based on bioaffinity interactions. Biosens Bioelectron. 1998 Oct 1;13(7-8):741-56. [Content Brief]
[2]. Hendle J, et al. Structure/activity relationship of adenine-modified NAD derivatives with respect to porcine heart lactate dehydrogenase isozyme H4 simulated with molecular mechanics. European journal of biochemistry. 1993 May 01;213(3):947-56. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
N6-(2-Aminoethyl)-NAD+ Related Classifications
HY-131829 Related Classifications
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