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Results for "

Alkaline phosphatase Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Phosphatase (23) Akt (1) Aminotransferases (Transaminases) (1) Antibiotic (1) Apoptosis (2) Bacterial (2) Carbonic Anhydrase (1) Caspase (1) Cholinesterase (ChE) (2) COX (3) DNA/RNA Synthesis (1) Drug Derivative (1) Drug Intermediate (2) Drug Isomer (1) Endogenous Metabolite (5) Environmental Pollutants (1) Estrogen Receptor/ERR (2) Fluorescent Dye (1) Fungal (1) Isotope-Labeled Compounds (2) Leukotriene Receptor (1) NF-κB (2) p38 MAPK (2) Parasite (2) Phosphorylase (1) Potassium Channel (3) Progesterone Receptor (1) RANKL/RANK (1) Reactive Oxygen Species (ROS) (1) Reference Standards (5) Toll-like Receptor (TLR) (2)
By Research Areas:	Cancer (12) Cardiovascular Disease (2) Endocrinology (2) Infection (4) Inflammation/Immunology (15) Metabolic Disease (11) Neurological Disease (1)

By Targets:

Phosphatase (23)

Akt (1)

Aminotransferases (Transaminases) (1)

Antibiotic (1)

Apoptosis (2)

Bacterial (2)

Carbonic Anhydrase (1)

Caspase (1)

Cholinesterase (ChE) (2)

COX (3)

DNA/RNA Synthesis (1)

Drug Derivative (1)

Drug Intermediate (2)

Drug Isomer (1)

Endogenous Metabolite (5)

Environmental Pollutants (1)

Estrogen Receptor/ERR (2)

Fluorescent Dye (1)

Fungal (1)

Isotope-Labeled Compounds (2)

Leukotriene Receptor (1)

NF-κB (2)

p38 MAPK (2)

Parasite (2)

Phosphorylase (1)

Potassium Channel (3)

Progesterone Receptor (1)

RANKL/RANK (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (5)

Toll-like Receptor (TLR) (2)

By Research Areas:

Cancer (12)

Cardiovascular Disease (2)

Endocrinology (2)

Infection (4)

Inflammation/Immunology (15)

Metabolic Disease (11)

Neurological Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

MCE-Kits

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Phosphatase Serpin SHP2 PhosTACs PTEN SHP1

Art. -Nr.	Produktname	Target	Forschungsgebiete	Chemical Structure

HY-D0852

Sodium orthovanadate 10+ Cited Publications	Phosphatase	Cancer
Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue.

HY-B1467

Domiphen bromide 1 Publications Verification	Potassium Channel Bacterial Parasite Phosphatase	Infection Inflammation/Immunology
Domiphen bromide is a cationic active quaternary ammonium salt and also an inhibitor of HERG channels (IC₅₀: 9 nM), aminopeptidase-like enzymes, Escherichia coli alkaline phosphatase, and α-chymotrypsin. Domiphen bromide has multiple activities such as antibacterial, antimalarial, and disinfectant properties, and it is also a synergist of Colistin (HY-113678). Domiphen bromide can be used as a chemical preservative and a cationic surfactant, and it can also be used in the research of bacterial infectious diseases such as pharyngitis, thrush, and oral ulcers .

HY-19695

(-)-p-Bromotetramisole oxalate 1 Publications Verification L-p-Bromotetramisole oxalate; 6-Bromolevamisole oxalate	Phosphatase	Cancer
(-)-p-Bromotetramisole oxalate (L-p-Bromotetramisole oxalate) is an **alkaline phosphatase** inhibitor. (-)-p-Bromotetramisole (oxalate) is applicable to research related to erythroleukemia .

HY-124756

SBI-425 3 Publications Verification	Phosphatase	Cardiovascular Disease
SBI-425 is an orally active and potent TNAP (tissue-nonspecific alkaline phosphatase) inhibitor (IC₅₀=16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival .

HY-119443

Neridronate	Phosphatase	Metabolic Disease
Neridronate is an aminobisphosphonate. Neridronate induces osteoblast differentiation, enhances **alkaline phosphatase** activity and mineralized nodule formation. Neridronate inhibits endothelial cell proliferation, fibroblast growth factor-2-induced capillary-like tube formation, and angiogenesis. Neridronate can be used for osteogenesis imperfecta and Paget’s disease of bone .

HY-14210

TNAP-IN-1	Phosphatase	Inflammation/Immunology
TNAP-IN-1 (Compound 1) is a selective tissue-nonspecific alkaline phosphatase (TNAP) inhibitor, with an IC₅₀ of 0.19 μM. TNAP-IN-1 can be used for the research of soft tissue calcification .

HY-W008385

H-HoArg-OH	Endogenous Metabolite	Metabolic Disease
H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver **alkaline phosphatase**.

HY-78144

4-Methylsalicylic acid	Drug Derivative Drug Intermediate	Inflammation/Immunology
4-Methylsalicylic acid is a methyl derivative of Salicylic acid (HY-B0167). 4-Methylsalicylic acid derivatives inhibit the activity of alkaline phosphatases such as TNAP and IAP. 4-Methylsalicylic acid derivatives exhibit immunosuppressive activity .

HY-N6663

3-Carene	Environmental Pollutants COX	Inflammation/Immunology
3-Carene is a bicyclic monoterpene in essential oils extracted from pine trees. 3-Carene inhibits nociceptive stimulus-induced inflammatory infiltrates and COX-2 overexpression, and with antinociceptive effect. 3-Carene stimulates the activity and expression of alkaline phosphatase that is an early phase marker of osteoblastic differentiation .

HY-125539

Roridin E	Antibiotic Phosphatase Fungal	Infection
Roridin E is a *glucose-6-phosphatase* (G6Pase) inhibitor and antibiotic, and is a metabolic byproduct of Roridin A (HY-N9599). Roridin E induces significant oxidative stress, characterized by depletion of glutathione in vivo, induction of hepatic lipid peroxidation, and inhibition of renal superoxide dismutase activity. Roridin E reduces blood glucose levels in rats, but exhibits acute toxicity (which is enhanced when co-administered with linoleic acid (HY-N0729)) and causes hepatotoxicity in male albino mice. Roridin E induces a decrease in total blood protein and increases in the levels of total lipids, γ-glutamyltransferase, alkaline phosphatase, and 5'-nucleotidase. Roridin E can be isolated from molds, and possesses cytostatic and antifungal activities similar to those of Verrucarin A (HY-107426) and Roridin A. Roridin E exhibits in vivo activity in rodents and is commonly used in hepatotoxicity-related studies .

HY-B2203

Monocalcium glycerophosphate	Phosphatase	Metabolic Disease
Monocalcium glycerophosphate is an inhibitor of *intestinal alkaline* phosphatase F3**, and it has anti-cavity properties. Monocalcium glycerophosphate is a source of calcium and phosphorus in total parenteral nutrition solutions, helps prevent the mineralization and development of bones from intravenous nutrition, and maintains the integrity of the intestinal epithelium .

HY-124478

Ethyl gentisate Ethyl 2,5-dihydroxybenzoate	Phosphatase	Metabolic Disease
Ethyl gentisate (Ethyl 2,5-dihydroxybenzoate) is a dual modulator for cell differentiation, that enhances the osteogenic differentiation of human mesenchymal stem cells (hMSCs) and alkaline phosphatase activity, inhibits RANKL-activated osteoclastogenesis in RAW264.7 cells, and balances the bone remodeling process .

HY-13636A

Fulvestrant (S enantiomer) ICI 182780 (S enantiomer); ZD 9238 (S enantiomer); ZM 182780 (S enantiomer)	Drug Isomer Estrogen Receptor/ERR p38 MAPK Apoptosis	Cancer
Fulvestrant (ICI 182780; ZD 9238) S enantiomer is the S-enantiomer of Fulvestrant (HY-13636), a potent estrogen receptor inhibitor. Fulvestrant binds to and blocks the estrogen receptor, promotes its degradation, and thereby inhibits receptor dimerization, nucleocytoplasmic shuttling and transcriptional activity. Fulvestrant effectively blocks estrogen signaling, MAPK pathway activation and ER-regulated protein expression. Fulvestrant induces apoptosis, inhibits the proliferation of breast cancer and prolactinoma cells, and reduces the mineralization level, alkaline phosphatase activity and osteocalcin expression of preosteoblasts. Prenatal exposure to Fulvestrant impairs ovarian follicular development and causes ovarian structural damage. Fulvestrant has been widely used in studies related to breast cancer, prolactinoma and other conditions .

HY-161916

Polθ-IN-4	DNA/RNA Synthesis	Cancer
Polθ-IN-4 is an orally active prodrug of a DNA polymerase θ (Polθ) inhibitor with K_ms of 3.7, 3.7 and 5.2 μM in human, mouse and rat recombinant alkaline phosphatases. Polθ-IN-4 that inhibits Polθ activity by targeting its ATP-dependent helicase domain. Polθ-IN-4 demonstrates significant anti-tumor activity in multiple animal experiments. Polθ-IN-4 can be used for the studies of breast cancer and ovarian cancer .

HY-168207

TH023	Toll-like Receptor (TLR) NF-κB	Inflammation/Immunology
TH023 is an inhibitor for the TLR4 signaling pathway, that targets especially the formation of TLR4 homodimer. TH023 inhibits secreted embryonic alkaline phosphatase in cell HEK-Blue hTLR4 with an IC₅₀ of 0.354 μM, and inhibits the NO expression in RAW264.7 with an IC₅₀ of 1.61μM. TH023 also inhibits the activation of NF-κB, reduces the nuclear translocation of NF-κB p65. TH023 exhibits anti-inflammatory efficacy in LPS (HY-D1056)-induced mouse acute sepsis model, and ameliorates the mouse lung injury .

HY-W661499

Orellanine	Phosphatase Apoptosis Reactive Oxygen Species (ROS) Caspase	Cancer
Orellanine, a nephrotoxic alkaloid found in Cortinarius orellanus, is an orally active and selective non-competitive inhibitor of **alkaline phosphatase. Orellanine chelates iron, generates reactive oxygen species (ROS*), induces DNA scission, forms ortho-semiquinone radicals, downregulates antioxidant defenses, and inhibits* mitochondrial function. Orellanine induces caspase 8/9-mediated apoptosis. Orellanine inhibits synthesis of proteins, RNA, DNA, and mitochondrial protein synthesis, with metabolic activation required for cell-free protein synthesis inhibition. Orellanine can be used for the research of metastatic clear cell renal cell carcinoma, acute renal failure, chronic renal insufficiency, and kidney damage .

HY-W008385R

H-HoArg-OH (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver alkaline phosphatase.

HY-W008385S

H-HoArg-OH-d4	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
H-HoArg-OH-d₄ is a deuterium labeled H-HoArg-OH (HY-W008385). H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver **alkaline phosphatase**.

HY-169703

SPA0355 1 Publications Verification	RANKL/RANK p38 MAPK Akt NF-κB	Inflammation/Immunology
SPA0355 is a thiourea derivative that has antioxidant and anti-inflammatory properties. SPA0355 inhibits the RANKL (receptor activator of nuclear factor κB ligand) induced osteoclast formation in primary bone marrow-derived macrophages. SPA0355 also suppresses the activation of the MAPKs, Akt, and NF-κB pathways. Additionally, SPA0355 promotes osteoblast differentiation, increases alkaline phosphatase activity, and enhances mineral nodule formation. SPA0355 can protect ovariectomized mice from bone loss by stimulating osteoblast differentiation and inhibiting osteoclast resorption, making it useful for studying postmenopausal osteoporosis .

HY-P1984

Alphostatin	Phosphatase	Others
Alphostatin is a bovine liver alkaline phosphatase inhibitor .

HY-163408

ALP-IN-1	Phosphatase	Others
ALP-IN-1 (Compound 7e) is an alkaline phosphatase (ALP) inhibitor (IC₅₀ = 0.308 µM) .

HY-129276

N-Retinoyl phenylalanine	Phosphatase	Cancer
N-Retinoyl phenylalanine is a potent alkaline phosphatase isoenzymes inhibitor with cytotoxicity. N-Retinoyl phenylalanine is promising for research of cancers .

HY-128005

ML085	Phosphatase	Metabolic Disease Endocrinology Cancer
ML085 is an inhibitor of placental alkaline phosphatase (PLAP). ML085 can be used in the research of testicular tumors, endocrine and metabolic diseases, and genitourinary system diseases .

HY-N12108

Forphenicine	Phosphatase	Infection Inflammation/Immunology Cancer
Forphenicine is a bacterial metabolite that is found in S. fulvoviridis and an inhibitor of **alkaline phosphatase*. Forphenicine inhibits* the growth of HL-60 leukemia cells at 10 µM. Forphenicine also increases survival in a guinea pig model of experimental autoimmune encephalomyelitis (EAE) .

HY-106064A

Piriprost potassium U 60257B	Leukotriene Receptor	Inflammation/Immunology
Piriprost (U-60,257B) potassium is an inhibitor of leukotriene synthesis. Piriprost potassium inhibits the release of both leukotriene and histamine with an IC₅₀ of 0.11 μM from isolated porcine lung cells. Piriprost potassium increases alkaline phosphatase (ALP) activity in cultured endometrial stromal cells .

HY-106417

Limazocic SA 3443	Phosphatase Aminotransferases (Transaminases)	Metabolic Disease
Limazocic (SA 3443) is an orally active hepatoprotective agent. Limazocic can inhibit increases in serum transaminase, **alkaline phosphatase** activity and hepatic lipids, hydroxyproline content induced by CCl4. Limazocic can decrease the degree of hepatic necrosis, fibrosis and steatosis. Limazocic can be used for the research of chronic liver injuries .

HY-149865

TPE-1p	Phosphatase Fluorescent Dye	Cancer
TPE-1p is a cascade-activated AIEgen-peptide probe. TPE-1p self-assembles in aqueous solution to exhibit bright fluorescence in response to alkaline phosphatase (ALP) and ChT-L. TPE-1p can be utilized to noninvasively assess the inhibition efficiency of a ChT-L inhibitor in cells .

HY-157139

ALP/Carbonic anhydrase-IN-1	Carbonic Anhydrase Phosphatase	Inflammation/Immunology
ALP/Carbonic anhydrase-IN-1 (Compound 1e) is a dual carbonic anhydrase (CA) and alkaline phosphatase (ALP) inhibitor. ALP/Carbonic anhydrase-IN-1 shows IC₅₀ values of 0.44 µM, 1.61 µM, 0.51 µM, and 0.107 µM for CA-II, CA-IX, CA-XII, and ALP, respectively .

HY-N2511S

Trimyristin--d15	Isotope-Labeled Compounds Cholinesterase (ChE) Phosphatase Endogenous Metabolite	Metabolic Disease
Trimyristin--d₁₅ is the deuterium labeled Trimyristin. Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC₅₀s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively .

HY-N14549

Cycloepoxydon	Phosphatase	Inflammation/Immunology
Cycloepoxydon inhibits the Phorbol 12-myristate 13-acetate (HY-18739) (PMA)-induced NF-KB and AP-1 mediated secreted alkaline phosphatase (SEAP) expression with IC₅₀s of 1-2 μg/mL (4.2-8.4 μM) and 3-5 μg/mL (12.6-21 μM), respectively .

HY-15321A

Etoricoxib hydrochloride MK-0663 hydrochloride; L-791456 hydrochloride	COX	Inflammation/Immunology
Etoricoxib hydrochloride (MK-0663 hydrochloride) is a synthetic nonsteroidal anti-inflammatory drug with cyclooxygenase-2 inhibitory activity. Etoricoxib hydrochloride can inhibit the conversion of arachidonic acid to prostaglandins, thereby reducing inflammation and pain. Etoricoxib hydrochloride is used to inhibit osteoarthritis and has anti-inflammatory and bone remodeling effects. The formulation of etoricoxib hydrochloride is prepared by emulsion solvent evaporation technology and exhibits good cell compatibility and enhanced alkaline phosphatase activity .

HY-N2511R

Trimyristin (Standard)	Reference Standards Cholinesterase (ChE) Phosphatase Endogenous Metabolite	Metabolic Disease
Trimyristin (Standard) is the analytical standard of Trimyristin. This product is intended for research and analytical applications. Trimyristin, an active molluscicidal component of?Myristica fragrans?Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of?Lymnaea acuminata. IC50s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively .

HY-138302

PF-06862309	Drug Intermediate	Cancer
PF-06862309 is a PF-06843195 (HY-131972) phosphate ester prodrug. PF-06862309 can be hydrolyzed to PF-06843195 in the presence of alkaline phosphatase. PF-06843195 is a highly selective PI3Kα inhibitor. PF-06862309 can be used for the study of breast cancer with ER ⁺, HER ^2-, and PIK3CA mutations .

HY-119443R

Neridronate (Standard)	Reference Standards Phosphatase	Metabolic Disease Inflammation/Immunology
Neridronate (Standard) is the analytical standard of Neridronate (HY-119443). This product is intended for research and analytical applications. Neridronate is an aminobisphosphonate. Neridronate induces osteoblast differentiation, enhances **alkaline phosphatase** activity and mineralized nodule formation. Neridronate inhibits endothelial cell proliferation, fibroblast growth factor-2-induced capillary-like tube formation, and angiogenesis. Neridronate can be used for osteogenesis imperfecta and Paget’s disease of bone .

HY-N6663R

3-Carene (Standard)	Reference Standards COX	Inflammation/Immunology
3-Carene (Standard) is the analytical standard of 3-Carene. This product is intended for research and analytical applications. 3-Carene is a bicyclic monoterpene in essential oils extracted from pine trees. 3-Carene inhibits nociceptive stimulus-induced inflammatory infiltrates and COX-2 overexpression, and with antinociceptive effect. 3-Carene stimulates the activity and expression of alkaline phosphatase that is an early phase marker of osteoblastic differentiation .

HY-B1467R

Domiphen bromide (Standard)	Reference Standards Potassium Channel Bacterial Parasite Phosphorylase	Infection Inflammation/Immunology
Domiphen bromide (Standard) is the analytical standard of Domiphen bromide (HY-B1467). This product is intended for research and analytical applications. Domiphen bromide is a cationic active quaternary ammonium salt and also an inhibitor of HERG channels (IC₅₀: 9 nM), aminopeptidase-like enzymes, Escherichia coli alkaline phosphatase, and α-chymotrypsin. Domiphen bromide has multiple activities such as antibacterial, antimalarial, and disinfectant properties, and it is also a synergist of Colistin (HY-113678). Domiphen bromide can be used as a chemical preservative and a cationic surfactant, and it can also be used in the research of bacterial infectious diseases such as pharyngitis, thrush, and oral ulcers.

HY-181345

OP-1690	Estrogen Receptor/ERR	Cancer
OP-1690 is a complete estrogen receptor (ERα) antagonist (CERAN), with pIC₅₀ values of 7.5 and 7.9 in alkaline phosphatase (AP) activity assay and TR-FRET assay, respectively. OP-1690 modulates receptor function by inducing ERα tetramerization, effectively induces ERα degradation, inhibits target gene transcription, but exhibits low antiproliferative potency. OP-1690 can be used for breast cancer research .

HY-119080

CP8754	Progesterone Receptor	Endocrinology Cancer
CP8754 is an orally active, selective human progesterone receptor (hPR) antagonist that blocks progesterone-mediated signaling pathways. CP8754 competitively inhibits the binding of [ ³H]-progesterone to hPR. And in vitro, CP8754 inhibits progesterone-dependent exogenous luciferase and endogenous alkaline phosphatase expression; while in vivo, CP8754 inhibits rabbit endometrial transformation. CP8754 does not significantly bind to human glucocorticoid receptors (hGR), estrogen receptors (hER), or rat androgen receptors (rAR). CP8754 can be used in the study of progesterone-related diseases such as breast cancer, endometriosis, uterine fibroids, and meningioma, as well as hormone-dependent tumors .

HY-186062

HCN-IN-1	Toll-like Receptor (TLR) Potassium Channel Phosphatase	Cardiovascular Disease Neurological Disease Inflammation/Immunology
HCN-IN-1 is a TLR4 inhibitor and HCN channel modulator with activity against HCN2 and HCN4.HCN-IN-1 inhibits TLR4-mediated alkaline phosphatase (SEAP) signal activity.HCN-IN-1 reduces HCN2 current across tested voltages, shifts voltage-dependent activation to more hyperpolarized potentials, slows activation kinetics, and does not affect deactivation process.HCN-IN-1 blocks HCN4 current.HCN-IN-1 exhibits analgesic, anti-inflammatory, and anti-anginal effects.HCN-IN-1 can be used for the research of inflammatory pain, neuropathic pain, heart failure, inflammation .

Art. -Nr.	Produktname	Type