Piriprost potassium
Piriprost potassium (U 60257B) is an inhibitor of Glutathione-S-transferase and leukotriene biosynthesis inhibitor. Piriprost potassium inhibits the biosynthesis of leukotriene C/D without affecting cyclooxygenase-mediated arachidonic acid metabolites. Piriprost potassium increases the activity of alkaline phosphatase (ALP). Piriprost potassium antagonizes contractions induced by leukotriene C/D in vitro. Piriprost potassium is used in asthma research.
For research use only. We do not sell to patients.
- CAS No.: 88851-62-1
- Formula: C26H34KNO4
- Molecular Weight:463.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Piriprost potassium inhibits leukotriene C/D synthesis in rat peritoneal mononuclear cells with an ID50 of 4.57 μM, without affecting cyclooxygenase-derived arachidonic acid metabolism products[1].
Piriprost potassium inhibits rat basophilic leukemia cell glutathione-S-transferase activity with an ID50 of 37 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 88851-62-1
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Molecular Weight 463.65
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Formula C26H34KNO4
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SMILES
O=C(O[K])CCCCC1=CC([C@H]([C@@H](C2)O)/C=C/[C@@H](O)CCCCC)=C2N1C3=CC=CC=C3
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Synonyms
U 60257B
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. van der Meer JW, et al. Abstract!. The Netherlands journal of medicine. 2002 Dec;60(11):418. [Content Brief]
[2]. Cejic SS, et al. Examination of the effects of piriprost (U-60,257B) on alkaline phosphatase activity of rat endometrial stromal cells in vitro. Prostaglandins. 1991 Aug;42(2):179-89. [Content Brief]
[3]. McCormack DG, et al. The contrasting influence of two lipoxygenase inhibitors on hypoxic pulmonary vasoconstriction in anesthetized pigs. Am Rev Respir Dis. 1989 Jan;139(1):100-5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Piriprost potassium Related Classifications
HY-106064A Related Classifications
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