88851-62-1
Chemical Structure
Piriprost potassium
Synonym(s): U 60257B
- CAS No.: 88851-62-1
- Formula:C26H34KNO4
- Molecular Weight:463.65
IUPAC Name: potassium 5-((4R,5R)-5-hydroxy-4-((S,E)-3-hydroxyoct-1-en-1-yl)-1-phenyl-1,4,5,6-tetrahydrocyclopenta[b]pyrrol-2-yl)pentanoate
InChIKey: UFJDMFZMRXDIKI-FFGYHVHASA-M
SMILES: O=C(O[K])CCCCC1=CC([C@H]([C@@H](C2)O)/C=C/[C@@H](O)CCCCC)=C2N1C3=CC=CC=C3
Biological Activity: Piriprost (U-60,257B) potassium is an inhibitor of leukotriene synthesis. Piriprost potassium inhibits the release of both leukotriene and histamine with an IC50 of 0.11 μM from isolated porcine lung cells. Piriprost potassium increases alkaline phosphatase (ALP) activity in cultured endometrial stromal cells[1][2].
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Piriprost potassium | Piriprost (U-60,257B) potassium is an inhibitor of leukotriene synthesis. Piriprost potassium inhibits the release of both leukotriene and histamine with an IC50 of 0.11 μM from isolated porcine lung cells. Piriprost potassium increases alkaline phosphatase (ALP) activity in cultured endometrial stromal cells. | |||||||||||||||||||||
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- [1]. Cejic SS, Kennedy TG. Examination of the effects of piriprost (U-60,257B) on alkaline phosphatase activity of rat endometrial stromal cells in vitro. Prostaglandins. 1991 Aug;42(2):179-89. [Content Brief]
- [2]. McCormack DG, Paterson NA. The contrasting influence of two lipoxygenase inhibitors on hypoxic pulmonary vasoconstriction in anesthetized pigs. Am Rev Respir Dis. 1989 Jan;139(1):100-5. [Content Brief]
Keywords
