88851-62-1
Chemical Structure
Piriprost potassium
Synonym(s): U 60257B
- CAS No.: 88851-62-1
- Formula:C26H34KNO4
- Molecular Weight:463.65
IUPAC Name: potassium 5-((4R,5R)-5-hydroxy-4-((S,E)-3-hydroxyoct-1-en-1-yl)-1-phenyl-1,4,5,6-tetrahydrocyclopenta[b]pyrrol-2-yl)pentanoate
InChIKey: UFJDMFZMRXDIKI-FFGYHVHASA-M
SMILES: O=C(O[K])CCCCC1=CC([C@H]([C@@H](C2)O)/C=C/[C@@H](O)CCCCC)=C2N1C3=CC=CC=C3
Biological Activity: Piriprost potassium (U 60257B) is an inhibitor of Glutathione-S-transferase and leukotriene biosynthesis inhibitor. Piriprost potassium inhibits the biosynthesis of leukotriene C/D without affecting cyclooxygenase-mediated arachidonic acid metabolites. Piriprost potassium increases the activity of alkaline phosphatase (ALP). Piriprost potassium antagonizes contractions induced by leukotriene C/D in vitro. Piriprost potassium is used in asthma research[1][2][3].
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Piriprost potassium | Piriprost potassium (U 60257B) is an inhibitor of Glutathione-S-transferase and leukotriene biosynthesis inhibitor. Piriprost potassium inhibits the biosynthesis of leukotriene C/D without affecting cyclooxygenase-mediated arachidonic acid metabolites. Piriprost potassium increases the activity of alkaline phosphatase (ALP). Piriprost potassium antagonizes contractions induced by leukotriene C/D in vitro. Piriprost potassium is used in asthma research. | |||||||||||||||||||||
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References
- [1]. van der Meer JW, et al. Abstract!. The Netherlands journal of medicine. 2002 Dec;60(11):418. [Content Brief]
- [2]. Cejic SS, et al. Examination of the effects of piriprost (U-60,257B) on alkaline phosphatase activity of rat endometrial stromal cells in vitro. Prostaglandins. 1991 Aug;42(2):179-89. [Content Brief]
- [3]. McCormack DG, et al. The contrasting influence of two lipoxygenase inhibitors on hypoxic pulmonary vasoconstriction in anesthetized pigs. Am Rev Respir Dis. 1989 Jan;139(1):100-5. [Content Brief]
