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Cat. No.: HY-186062

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HCN-IN-1

HCN-IN-1 is a TLR4 inhibitor and HCN channel modulator with activity against HCN2 and HCN4.HCN-IN-1 inhibits TLR4-mediated alkaline phosphatase (SEAP) signal activity.HCN-IN-1 reduces HCN2 current across tested voltages, shifts voltage-dependent activation to more hyperpolarized potentials, slows activation kinetics, and does not affect deactivation process.HCN-IN-1 blocks HCN4 current.HCN-IN-1 exhibits analgesic, anti-inflammatory, and anti-anginal effects.HCN-IN-1 can be used for the research of inflammatory pain, neuropathic pain, heart failure, inflammation.

For research use only. We do not sell to patients.

CAS No.: 2234283-04-4
Formula: C₂₈H₃₈ClN₃O₂
Molecular Weight:484.07

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HCN-IN-1 Chemical Structure

CAS No.: 2234283-04-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

TLR4

KCNQ2

KCNQ4

All Toll-like Receptor (TLR) Isoforms :

In Vitro

HCN-IN-1 (compound 5) (0.39-100 μM; 24 h) concentration-dependently inhibits TLR4 alkaline phosphatase (SEAP) signal intensity in HEK BLUE TLR4 cells, with significant inhibition observed at concentrations of 25 μM and above^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2234283-04-4
Molecular Weight 484.07
Formula C₂₈H₃₈ClN₃O₂
SMILES

ClC1=C(CN2N=C(C)C(CN(CC(CCOC3=CC=C(C(C)(C)C)C=C3)O)C)=C2C)C=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cheng Kui, et al. A kind of fortified phenol beta-alkamine analog derivative and its preparation method and application. CN109867627A.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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HCN-IN-1

All Toll-like Receptor (TLR) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HCN-IN-1 Related Classifications

HY-186062 Related Classifications