2. Immunology/Inflammation Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. Toll-like Receptor (TLR) Potassium Channel Phosphatase
  4. HCN-IN-1

HCN-IN-1 is a TLR4 inhibitor and HCN channel modulator with activity against HCN2 and HCN4.HCN-IN-1 inhibits TLR4-mediated alkaline phosphatase (SEAP) signal activity.HCN-IN-1 reduces HCN2 current across tested voltages, shifts voltage-dependent activation to more hyperpolarized potentials, slows activation kinetics, and does not affect deactivation process.HCN-IN-1 blocks HCN4 current.HCN-IN-1 exhibits analgesic, anti-inflammatory, and anti-anginal effects.HCN-IN-1 can be used for the research of inflammatory pain, neuropathic pain, heart failure, inflammation.

For research use only. We do not sell to patients.

HCN-IN-1

HCN-IN-1 Chemical Structure

CAS No. : 2234283-04-4

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HCN-IN-1 Related Antibodies

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Description

HCN-IN-1 is a TLR4 inhibitor and HCN channel modulator with activity against HCN2 and HCN4.HCN-IN-1 inhibits TLR4-mediated alkaline phosphatase (SEAP) signal activity.HCN-IN-1 reduces HCN2 current across tested voltages, shifts voltage-dependent activation to more hyperpolarized potentials, slows activation kinetics, and does not affect deactivation process.HCN-IN-1 blocks HCN4 current.HCN-IN-1 exhibits analgesic, anti-inflammatory, and anti-anginal effects.HCN-IN-1 can be used for the research of inflammatory pain, neuropathic pain, heart failure, inflammation[1].

IC50 & Target

TLR4

 

KCNQ2

 

KCNQ4

 

In Vitro

HCN-IN-1 (compound 5) (0.39-100 μM; 24 h) concentration-dependently inhibits TLR4 alkaline phosphatase (SEAP) signal intensity in HEK BLUE TLR4 cells, with significant inhibition observed at concentrations of 25 μM and above[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HCN-IN-1 Related Antibodies
Molecular Weight

484.07

Formula

C28H38ClN3O2
CAS No.
SMILES

ClC1=C(CN2N=C(C)C(CN(CC(CCOC3=CC=C(C(C)(C)C)C=C3)O)C)=C2C)C=CC=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HCN-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HCN-IN-12234283-04-4Toll-like Receptor (TLR)Potassium ChannelPhosphataseKcsAHCN channelheart failureTLR4HCN2SEAPneuropathic painalkaline phosphataseHCN4inflammatory painHEK BLUE TLR4 cellsInhibitorinhibitorinhibit

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