2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. H-HoArg-OH

H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver alkaline phosphatase.

For research use only. We do not sell to patients.

H-HoArg-OH Chemical Structure

H-HoArg-OH Chemical Structure

CAS No. : 156-86-5

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 28 In-stock
Solution
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Solid
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5 g USD 50 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of H-HoArg-OH:

H-HoArg-OH Related Antibodies

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Description

H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver alkaline phosphatase.

IC50 & Target[1]

Alkaline phosphatase

 

Human Endogenous Metabolite

 

In Vitro

It is found that H-HoArg-OH (L-homoarginine), a homologue of arginine, is a strong inhibitor of human bone and liver alkaline phosphatase while it has virtually no effect on intestinal and placental alkaline phosphatases unlike H-HoArg-OH which inhibits intestinal and placental alkaline phosphatases but not the liver and bone enzymes. These four tissues mentioned are the major contributors to the serum alkaline phosphatase[1]. It is also indicated that low levels of the endogenous amino acid H-HoArg-OH are linked to cardiovascular disease[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

H-HoArg-OH Related Antibodies
Molecular Weight

188.23

Formula

C7H16N4O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[H][C@](N)(CCCCNC(N)=N)C(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (531.26 mM; Need ultrasonic)

DMSO : 1 mg/mL (5.31 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.3126 mL 26.5632 mL 53.1265 mL
5 mM 1.0625 mL 5.3126 mL 10.6253 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (531.26 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (243 KB) HNMR (129 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 5.3126 mL 26.5632 mL 53.1265 mL 132.8162 mL
5 mM 1.0625 mL 5.3126 mL 10.6253 mL 26.5632 mL
H2O 10 mM 0.5313 mL 2.6563 mL 5.3126 mL 13.2816 mL
15 mM 0.3542 mL 1.7709 mL 3.5418 mL 8.8544 mL
20 mM 0.2656 mL 1.3282 mL 2.6563 mL 6.6408 mL
25 mM 0.2125 mL 1.0625 mL 2.1251 mL 5.3126 mL
30 mM 0.1771 mL 0.8854 mL 1.7709 mL 4.4272 mL
40 mM 0.1328 mL 0.6641 mL 1.3282 mL 3.3204 mL
50 mM 0.1063 mL 0.5313 mL 1.0625 mL 2.6563 mL
60 mM 0.0885 mL 0.4427 mL 0.8854 mL 2.2136 mL
80 mM 0.0664 mL 0.3320 mL 0.6641 mL 1.6602 mL
100 mM 0.0531 mL 0.2656 mL 0.5313 mL 1.3282 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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H-HoArg-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

H-HoArg-OH156-86-5Endogenous MetaboliteInhibitorinhibitorinhibit

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