H-HoArg-OH
Based on 1 Customer Validation
H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver alkaline phosphatase.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 156-86-5
- Formula: C7H16N4O2
- Molecular Weight:188.23
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Alkaline phosphatase |
Human Endogenous Metabolite |
It is found that H-HoArg-OH (L-homoarginine), a homologue of arginine, is a strong inhibitor of human bone and liver alkaline phosphatase while it has virtually no effect on intestinal and placental alkaline phosphatases unlike H-HoArg-OH which inhibits intestinal and placental alkaline phosphatases but not the liver and bone enzymes. These four tissues mentioned are the major contributors to the serum alkaline phosphatase[1]. It is also indicated that low levels of the endogenous amino acid H-HoArg-OH are linked to cardiovascular disease[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 156-86-5
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Appearance Solid
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Molecular Weight 188.23
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Formula C7H16N4O2
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Color White to off-white
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SMILES
[H][C@](N)(CCCCNC(N)=N)C(O)=O
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 100 mg/mL (531.26 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (531.26 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (269 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.3126 mL | 26.5632 mL | 53.1265 mL | 132.8162 mL |
| 5 mM | 1.0625 mL | 5.3126 mL | 10.6253 mL | 26.5632 mL | |
| 10 mM | 0.5313 mL | 2.6563 mL | 5.3126 mL | 13.2816 mL | |
| 15 mM | 0.3542 mL | 1.7709 mL | 3.5418 mL | 8.8544 mL | |
| 20 mM | 0.2656 mL | 1.3282 mL | 2.6563 mL | 6.6408 mL | |
| 25 mM | 0.2125 mL | 1.0625 mL | 2.1251 mL | 5.3126 mL | |
| 30 mM | 0.1771 mL | 0.8854 mL | 1.7709 mL | 4.4272 mL | |
| 40 mM | 0.1328 mL | 0.6641 mL | 1.3282 mL | 3.3204 mL | |
| 50 mM | 0.1063 mL | 0.5313 mL | 1.0625 mL | 2.6563 mL | |
| 60 mM | 0.0885 mL | 0.4427 mL | 0.8854 mL | 2.2136 mL | |
| 80 mM | 0.0664 mL | 0.3320 mL | 0.6641 mL | 1.6602 mL | |
| 100 mM | 0.0531 mL | 0.2656 mL | 0.5313 mL | 1.3282 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
H-HoArg-OH Related Classifications
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